Knowledge Bases in Rbbt
We will go bottom up in this section, starting with association databases and
index the building blocks. Knowledge bases fills a few gaps with the Entity
system to help automatize things.
Association databases
An association database is nothing but a TSV. The key/first-field pair
specifies an association source~target, the rest of the fields qualify it.
The file can be of any type, but note that :single and :flat types will not
have qualifiers; type :double requires that the qualifiers fields and the
target field match. Usually the key_field and the first field are of known
Entity types, but it is not required.
Trivial example
We begin by opening a TSV file as an association file. The
file we are opening is one that lists genes and their associated
GO terms. The file lists genes by their Ensembl Gene ID.
require 'rbbt-util'
require 'rbbt/association'
require 'rbbt/sources/organism'
assoc = Association.open(Organism.gene_go("Hsa/jan2013"))
gene = "ENSG00000146648"
puts "GO terms of #{gene}"
puts
assoc[gene].zip_fields.collect{|go, cat|
puts [cat, go] * ": "
}- Result
GO terms of ENSG00000146648 biological_process: GO:0006468 biological_process: GO:0007169 cellular_component: GO:0016021 cellular_component: GO:0016020 molecular_function: GO:0005524 molecular_function: GO:0004672 molecular_function: GO:0004713 molecular_function: GO:0016772 molecular_function: GO:0004714 molecular_function: GO:0004716 biological_process: GO:0008283 biological_process: GO:0007411 biological_process: GO:0043066 biological_process: GO:0000902 biological_process: GO:0008284 biological_process: GO:0007165 biological_process: GO:0048146 biological_process: GO:0000186 biological_process: GO:0016337 biological_process: GO:0048546 biological_process: GO:0006950 biological_process: GO:0007166 biological_process: GO:0030335 biological_process: GO:0045429 biological_process: GO:0001892 biological_process: GO:0043406 biological_process: GO:0050730 biological_process: GO:0051897 biological_process: GO:0046777 biological_process: GO:0001942 biological_process: GO:0007435 biological_process: GO:0045740 biological_process: GO:0001503 biological_process: GO:0050999 biological_process: GO:0050679 biological_process: GO:0051205 biological_process: GO:0007173 biological_process: GO:0000165 biological_process: GO:0021795 biological_process: GO:0042177 biological_process: GO:0007202 biological_process: GO:0060571 biological_process: GO:0045739 biological_process: GO:0042327 biological_process: GO:0042059 biological_process: GO:0031659 biological_process: GO:0035413 biological_process: GO:0043006 biological_process: GO:0070141 cellular_component: GO:0005634 cellular_component: GO:0005737 cellular_component: GO:0005886 cellular_component: GO:0005789 cellular_component: GO:0048471 cellular_component: GO:0000139 cellular_component: GO:0005615 cellular_component: GO:0016323 cellular_component: GO:0031965 cellular_component: GO:0010008 cellular_component: GO:0045121 cellular_component: GO:0005768 cellular_component: GO:0030139 cellular_component: GO:0030122 cellular_component: GO:0070435 molecular_function: GO:0005515 molecular_function: GO:0046982 molecular_function: GO:0003690 molecular_function: GO:0019899 molecular_function: GO:0051015 molecular_function: GO:0004888 molecular_function: GO:0042802 molecular_function: GO:0019903 molecular_function: GO:0004709 molecular_function: GO:0005006 molecular_function: GO:0030235 biological_process: GO:0042127 biological_process: GO:0008544 cellular_component: GO:0005622 molecular_function: GO:0004871 molecular_function: GO:0016301
Translating entities
So far this is no different than doing TSV.open; in fact, the result in this case
is the same, a TSV file. The Association module does more than just open the files, it
is aware of entities and their formats. Lets us try a different example, where the
association file is translated to use Associated Gene Name. For the translation to
work, Rbbt must be aware of the gene entity, which is defined in the Genomics workflow.
require 'rbbt-util'
require 'rbbt/association'
require 'rbbt/sources/organism'
require 'rbbt/workflow'
Workflow.require_workflow "Genomics"
require 'rbbt/entity/gene'
assoc = Association.open(Organism.gene_go("Hsa/jan2013"),
{:source_format => "Associated Gene Name"})
gene = "EGFR"
puts "Go terms of #{gene}"
puts
assoc[gene].zip_fields.collect{|go, cat|
puts [cat, go] * ": "
}- Result
Go terms of EGFR biological_process: GO:0006468 biological_process: GO:0007169 cellular_component: GO:0016021 cellular_component: GO:0016020 molecular_function: GO:0005524 molecular_function: GO:0004672 molecular_function: GO:0004713 molecular_function: GO:0016772 molecular_function: GO:0004714 molecular_function: GO:0004716 biological_process: GO:0008283 biological_process: GO:0007411 biological_process: GO:0043066 biological_process: GO:0000902 biological_process: GO:0008284 biological_process: GO:0007165 biological_process: GO:0048146 biological_process: GO:0000186 biological_process: GO:0016337 biological_process: GO:0048546 biological_process: GO:0006950 biological_process: GO:0007166 biological_process: GO:0030335 biological_process: GO:0045429 biological_process: GO:0001892 biological_process: GO:0043406 biological_process: GO:0050730 biological_process: GO:0051897 biological_process: GO:0046777 biological_process: GO:0001942 biological_process: GO:0007435 biological_process: GO:0045740 biological_process: GO:0001503 biological_process: GO:0050999 biological_process: GO:0050679 biological_process: GO:0051205 biological_process: GO:0007173 biological_process: GO:0000165 biological_process: GO:0021795 biological_process: GO:0042177 biological_process: GO:0007202 biological_process: GO:0060571 biological_process: GO:0045739 biological_process: GO:0042327 biological_process: GO:0042059 biological_process: GO:0031659 biological_process: GO:0035413 biological_process: GO:0043006 biological_process: GO:0070141 cellular_component: GO:0005634 cellular_component: GO:0005737 cellular_component: GO:0005886 cellular_component: GO:0005789 cellular_component: GO:0048471 cellular_component: GO:0000139 cellular_component: GO:0005615 cellular_component: GO:0016323 cellular_component: GO:0031965 cellular_component: GO:0010008 cellular_component: GO:0045121 cellular_component: GO:0005768 cellular_component: GO:0030139 cellular_component: GO:0030122 cellular_component: GO:0070435 molecular_function: GO:0005515 molecular_function: GO:0046982 molecular_function: GO:0003690 molecular_function: GO:0019899 molecular_function: GO:0051015 molecular_function: GO:0004888 molecular_function: GO:0042802 molecular_function: GO:0019903 molecular_function: GO:0004709 molecular_function: GO:0005006 molecular_function: GO:0030235 biological_process: GO:0042127 biological_process: GO:0008544 cellular_component: GO:0005622 molecular_function: GO:0004871 molecular_function: GO:0016301
Just a reminder: make the system aware of GO terms to list their descriptions.
GO term entities are defined in their rbbt/sources file.
require 'rbbt-util'
require 'rbbt/association'
require 'rbbt/sources/organism'
require 'rbbt/workflow'
Workflow.require_workflow "Genomics"
require 'rbbt/entity/gene'
require 'rbbt/sources/go'
assoc = Association.open(Organism.gene_go("Hsa/jan2013"),
{:source_format => "Associated Gene Name"})
gene = "EGFR"
puts "GO terms of #{gene}"
puts
assoc[gene].zip_fields.collect{|values|
# The short hand version used before does not setup the entities.
# Using values_at does
go, cat = values.values_at 0, 1
puts [cat, go.name] * ": "
}- Result
GO terms of EGFR biological_process: protein phosphorylation biological_process: transmembrane receptor protein tyrosine kinase signaling pathway cellular_component: integral to membrane cellular_component: membrane molecular_function: ATP binding molecular_function: protein kinase activity molecular_function: protein tyrosine kinase activity molecular_function: transferase activity, transferring phosphorus-containing groups molecular_function: transmembrane receptor protein tyrosine kinase activity molecular_function: receptor signaling protein tyrosine kinase activity biological_process: cell proliferation biological_process: axon guidance biological_process: negative regulation of apoptotic process biological_process: cell morphogenesis biological_process: positive regulation of cell proliferation biological_process: signal transduction biological_process: positive regulation of fibroblast proliferation biological_process: activation of MAPKK activity biological_process: cell-cell adhesion biological_process: digestive tract morphogenesis biological_process: response to stress biological_process: cell surface receptor signaling pathway biological_process: positive regulation of cell migration biological_process: positive regulation of nitric oxide biosynthetic process biological_process: embryonic placenta development biological_process: positive regulation of MAP kinase activity biological_process: regulation of peptidyl-tyrosine phosphorylation biological_process: positive regulation of protein kinase B signaling cascade biological_process: protein autophosphorylation biological_process: hair follicle development biological_process: salivary gland morphogenesis biological_process: positive regulation of DNA replication biological_process: ossification biological_process: regulation of nitric-oxide synthase activity biological_process: positive regulation of epithelial cell proliferation biological_process: protein insertion into membrane biological_process: epidermal growth factor receptor signaling pathway biological_process: MAPK cascade biological_process: cerebral cortex cell migration biological_process: negative regulation of protein catabolic process biological_process: activation of phospholipase C activity biological_process: morphogenesis of an epithelial fold biological_process: positive regulation of DNA repair biological_process: positive regulation of phosphorylation biological_process: negative regulation of epidermal growth factor receptor signaling pathway biological_process: positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S biological_process: positive regulation of catenin import into nucleus biological_process: activation of phospholipase A2 activity by calcium-mediated signaling biological_process: response to UV-A cellular_component: nucleus cellular_component: cytoplasm cellular_component: plasma membrane cellular_component: endoplasmic reticulum membrane cellular_component: perinuclear region of cytoplasm cellular_component: Golgi membrane cellular_component: extracellular space cellular_component: basolateral plasma membrane cellular_component: nuclear membrane cellular_component: endosome membrane cellular_component: membrane raft cellular_component: endosome cellular_component: endocytic vesicle cellular_component: AP-2 adaptor complex cellular_component: Shc-EGFR complex molecular_function: protein binding molecular_function: protein heterodimerization activity molecular_function: double-stranded DNA binding molecular_function: enzyme binding molecular_function: actin filament binding molecular_function: transmembrane signaling receptor activity molecular_function: identical protein binding molecular_function: protein phosphatase binding molecular_function: MAP kinase kinase kinase activity molecular_function: epidermal growth factor-activated receptor activity molecular_function: nitric-oxide synthase regulator activity biological_process: regulation of cell proliferation biological_process: epidermis development cellular_component: intracellular molecular_function: signal transducer activity molecular_function: kinase activity
ICGC Example
The same functionalities to specify sources and targets are available when
creating indexes. As our next example shows. Note how we do :persist the
database, otherwise we could not use Tokyocabinet’s B-tree range search; this
is the default, anyway. Note also the performance benchmark, a million queries
in 10 seconds i.e. 100K queries/second.
require 'rbbt-util'
require 'rbbt/association'
require 'rbbt/sources/organism'
require 'rbbt/workflow'
Workflow.require_workflow "Genomics"
require 'rbbt/entity/gene'
assoc = Association.index('ftp://data.dcc.icgc.org/current/Chronic_Lymphocytic_Leukemia-ISC_MICINN-ES/simple_somatic_mutation.CLLE-ES.tsv.gz',
{ :source => "gene_affected=~Ensembl Gene ID=>Associated Gene Name",
:target => "icgc_donor_id=~Sample",
:fields => ['consequence_type'],
:namespace => 'Hsa/jan2013',
:merge => true, :header_hash=>''}, :persist => true)
puts "Associations: ", assoc.match("SF3B1") * ", "
Misc.benchmark(1_000_000) do
assoc.match("SF3B1")
end
Misc.profile do
Misc.benchmark(1_000) do
assoc.match("SF3B1")
end
end- Result
Associations: SF3B1~DO6376, SF3B1~DO6392, SF3B1~DO6426, SF3B1~DO6436, SF3B1~DO6468, SF3B1~DO6494, SF3B1~DO6525, SF3B1~DO6898, SF3B1~DO7000 Benchmark for 1000000 repeats 12.530000 0.000000 12.530000 ( 12.532505)
Knowledge Bases
We are ready to put all this together into a knowledge base.
First example
Here we create a knowledge base, on a temporary directory, with namespace
Hsa/jan2013, and register the Pina protein-protein interaction database. We
need to specify that the target field Interactor UniProt/SwissProt Accession
should be interpreted as UniProt/SwissProt Accession. We have also specify that
the preferred format for Gene entities is Associated Gene Name.
The children method retrieves the matches from the database, annotated as
AssociationItem entities. This means we can easily extract the target,
and we can also extract the target_entity, which are annotated as their appropriate
entities; which can be viewed in this example when we use the Gene entity method ensembl
to translate them to Ensembl Gene ID. Of course, every new layer add some overhead.
Registering a database does not start its processing. Loading the databases,
indices, etc. is done on-demand. Once they are setup the first time, they will
be reused, as usual. Finally, note how the database is registered as
undirected, which includes the converse of each interaction to the index.
require 'rbbt-util'
require 'rbbt/knowledge_base'
require 'rbbt/util/tmpfile'
require 'rbbt/sources/organism'
require 'rbbt/workflow'
Workflow.require_workflow "Genomics"
require 'rbbt/entity/gene'
require 'rbbt/sources/pina'
TmpFile.with_dir do |dir|
kb = KnowledgeBase.new dir, "Hsa/jan2013"
kb.format["Gene"] = "Associated Gene Name"
kb.register :pina, Pina.protein_protein,
:target => "Interactor UniProt/SwissProt Accession=~UniProt/SwissProt Accession",
:undirected => true
gene = "SF3B1"
puts "Matches: ", kb.children(:pina, gene) * ", "
puts "Targets: ", kb.children(:pina, gene).target * ", "
puts "Ensembl: ", kb.children(:pina, gene).target_entity.ensembl * ", "
puts
Misc.benchmark(10_000) do
kb.indices[:pina].match(gene)
end
Misc.benchmark(10_000) do
kb.children(:pina, gene)
end
Misc.benchmark(10_000) do
kb.children(:pina, gene).target
end
Misc.benchmark(10_000) do
kb.children(:pina, gene).target_entity
end
end- Result
Matches: SF3B1~APBB1, SF3B1~ARF6, SF3B1~ARPC2, SF3B1~ATG12, SF3B1~BAZ1B, SF3B1~BRF2, SF3B1~CCNE1, SF3B1~CDC5L, SF3B1~CFLAR, SF3B1~DDX42, SF3B1~DYRK1A, SF3B1~GSK3B, SF3B1~H3F3B, SF3B1~HDAC3, SF3B1~IKBKE, SF3B1~MELK, SF3B1~MYC, SF3B1~PHF5A, SF3B1~PPP1R8, SF3B1~PRPF40A, SF3B1~PUF60, SF3B1~RBM17, SF3B1~RNPS1, SF3B1~SAP130, SF3B1~SF3A2, SF3B1~SF3B14, SF3B1~SF3B3, SF3B1~SF3B4, SF3B1~SF3B5, SF3B1~SMAD1, SF3B1~SMAD5, SF3B1~SMAD9, SF3B1~SMNDC1, SF3B1~SNIP1, SF3B1~SNRNP40, SF3B1~SNRPN, SF3B1~TCERG1, SF3B1~TOPORS, SF3B1~WBP4, SF3B1~WWOX, SF3B1~YWHAG, SF3B1~YWHAZ Targets: APBB1, ARF6, ARPC2, ATG12, BAZ1B, BRF2, CCNE1, CDC5L, CFLAR, DDX42, DYRK1A, GSK3B, H3F3B, HDAC3, IKBKE, MELK, MYC, PHF5A, PPP1R8, PRPF40A, PUF60, RBM17, RNPS1, SAP130, SF3A2, SF3B14, SF3B3, SF3B4, SF3B5, SMAD1, SMAD5, SMAD9, SMNDC1, SNIP1, SNRNP40, SNRPN, TCERG1, TOPORS, WBP4, WWOX, YWHAG, YWHAZ Ensembl: ENSG00000166313, ENSG00000165527, ENSG00000163466, ENSG00000145782, ENSG00000009954, ENSG00000104221, ENSG00000105173, ENSG00000096401, ENSG00000003402, ENSG00000198231, ENSG00000157540, ENSG00000082701, ENSG00000132475, ENSG00000171720, ENSG00000143466, ENSG00000165304, ENSG00000136997, ENSG00000100410, ENSG00000117751, ENSG00000196504, ENSG00000179950, ENSG00000134453, ENSG00000205937, ENSG00000136715, ENSG00000104897, ENSG00000115128, ENSG00000189091, ENSG00000143368, ENSG00000169976, ENSG00000170365, ENSG00000113658, ENSG00000120693, ENSG00000119953, ENSG00000163877, ENSG00000060688, ENSG00000128739, ENSG00000113649, ENSG00000197579, ENSG00000120688, ENSG00000186153, ENSG00000170027, ENSG00000164924 Benchmark for 10000 repeats 0.230000 0.010000 0.240000 ( 0.248403) Benchmark for 10000 repeats 0.870000 0.000000 0.870000 ( 0.865072) Benchmark for 10000 repeats 1.470000 0.000000 1.470000 ( 1.472894) Benchmark for 10000 repeats 3.010000 0.000000 3.010000 ( 3.017540)
We can also use the version method to do this automatically. It will create
a subdirectory in the knowledge base directory with the new namespace, create
a new knowledge base for it and copy the registry
require 'rbbt-util'
require 'rbbt/knowledge_base'
require 'rbbt/util/tmpfile'
require 'rbbt/sources/organism'
require 'rbbt/workflow'
Workflow.require_workflow "Genomics"
require 'genomics_kb'
namespace = "Hsa/may2009"
gene = "TP53"
puts "Organism (namespace) of interactors of #{gene} in the global Genomics KB"
found = Genomics.knowledge_base.identify :pina, gene
puts Genomics.knowledge_base.children(:pina, found).target_entity.organism
kb = Genomics.knowledge_base.version namespace
puts
puts "Organism (namespace) interactors of #{gene} in #{namespace} global KB"
found = kb.identify :pina, gene
puts kb.children(:pina, found).target_entity.organism - Result
Organism (namespace) of interactors of TP53 in the global Genomics KB Hsa/jan2013 Organism (namespace) interactors of TP53 in Hsa/may2009 global KB Hsa/may2009
Qualifying associations
The following example shows how to access they values that qualify each association. The
values property of AssociationItem entities returns a NamedArray with the qualification
values associated with their corresponding field names.
require 'rbbt-util'
require 'rbbt/knowledge_base'
require 'rbbt/util/tmpfile'
require 'rbbt/sources/organism'
require 'rbbt/workflow'
Workflow.require_workflow "Genomics"
require 'genomics_kb'
gene = "TP53"
puts "Interactors of #{gene}, with qualifiers"
found = Genomics.knowledge_base.identify :pina, gene
Genomics.knowledge_base.children(:pina, found).each do |match|
puts
puts match.target_entity.name << ": "
puts "Method= " << match.values["Method"]
puts "PMID= " << match.values["PMID"]
end- Result
Interactors of TP53, with qualifiers NFYA: Method= MI:0006;;MI:0006;;MI:0006;;MI:0006;;MI:0006;;MI:0006;;MI:0006;;MI:0006;;MI:0006;;MI:0004;;MI:0006;;MI:0493;;MI:0006;;MI:0006;;MI:0004;;MI:0004 PMID= 16959611;;16959611;;16959611;;16959611;;16959611;;16959611;;16959611;;16959611;;16959611;;15831478;;16959611;;16959611;;16959611;;16959611;;15831478;;15831478 CFLAR: Method= MI:0004;;MI:0004 PMID= 18559494;;18559494 KDM1A: Method= MI:0004;;MI:0004;;MI:0004;;MI:0004;;MI:0004;;MI:0004;;MI:0004 PMID= 17805299;;17805299;;17805299;;17805299;;17805299;;18573881;;18573881 DVL2: Method= MI:0018;;MI:0018;;MI:0018;;MI:0398;;MI:0096;;MI:0018;;MI:0096;;MI:0096 PMID= 16189514;;16189514;;16189514;;16189514;;16713569;;16189514;;16713569;;16713569 CREBBP: Method= MI:0006;;MI:0055;;MI:0493;;MI:0096;;MI:0401;;MI:0096;;MI:0096;;MI:0096;;MI:0006;;MI:0096;;MI:0096;;MI:0096;;MI:0096;;MI:0428;;MI:0006;;MI:0006;;MI:0415;;MI:0096;;MI:0096;;MI:0415;;MI:0004;;MI:0004;;MI:0096;;MI:0415;;MI:0096;;MI:0006 PMID= 9194564;;19166313;;11782467;;10848610;;10823891;;11782467;;14722092;;10196247;;9194564;;11782467;;10196247;;9288775;;9288775;;15632413;;9194564;;9194564;;19805293;;10196247;;10196247;;21390126;;12426395;;16537920;;9194564;;18485870;;9194564;;9194564 MLL5: Method= MI:0004 PMID= 21423215 CCL18: Method= MI:0018;;MI:0018;;MI:0492;;MI:0398;;MI:0018 PMID= 16169070;;16169070;;16169070;;16169070;;16169070 IFRD1: Method= MI:0004;;MI:0004 PMID= 17130840;;17130840 BTK: Method= MI:0492 PMID= 15355990 BRCA1: Method= MI:0493;;MI:0401;;MI:0096;;MI:0401;;MI:0096;;MI:0019;;MI:0096;;MI:0004;;MI:0401;;MI:0004 PMID= 9482880;;14636569;;9582019;;14636569;;9926942;;9482880;;9926942;;9482880;;14636569;;14710355 CAPN1: Method= MI:0493 PMID= 12432277 ZMYND11: Method= MI:0004 PMID= 17721438 MNAT1: Method= MI:0492;;MI:0415;;MI:0415;;MI:0493 PMID= 9372954;;9372954;;9372954;;9840937 VRK2: Method= MI:0415;;MI:0415 PMID= 16704422;;16704422 BAK1: Method= MI:0004;;MI:0004;;MI:0493;;MI:0004 PMID= 15077116;;15077116;;15077116;;15077116 PIAS1: Method= MI:0018;;MI:0018;;MI:0018;;MI:0492;;MI:0096;;MI:0096;;MI:0096;;MI:0096 PMID= 10380882;;11583632;;11583632;;15133049;;15133049;;15133049;;15133049;;11867732 RFC1: Method= MI:0004 PMID= 12509469 MED17: Method= MI:0004;;MI:0492 PMID= 10198638;;10198638 CUL7: Method= MI:0004;;MI:0077;;MI:0004;;MI:0004;;MI:0077;;MI:0077 PMID= 16547496;;17298945;;16547496;;16547496;;17298945;;17298945 EPHA3: Method= MI:0492;;MI:0096 PMID= 15355990;;15355990 HSPA5: Method= MI:0493;;MI:0006;;MI:0006 PMID= 17184779;;17184779;;17184779 RRM2B: Method= MI:0424;;MI:0424;;MI:0004;;MI:0493;;MI:0019 PMID= 19015526;;19015526;;12615712;;12615712;;12615712 MAPK9: Method= MI:0415;;MI:0004;;MI:0493 PMID= 9393873;;12384512;;9393873 RAD51: Method= MI:0493;;MI:0019;;MI:0019;;MI:0096;;MI:0096;;MI:0401;;MI:0004;;MI:0401;;MI:0096;;MI:0401;;MI:0493 PMID= 15064730;;9380510;;9380510;;8617246;;8617246;;14636569;;16983346;;14636569;;9380510;;14636569;;9380510 EIF2AK2: Method= MI:0004;;MI:0004;;MI:0004;;MI:0493;;MI:0004;;MI:0004 PMID= 10348343;;10348343;;10348343;;10348343;;10348343;;10348343 RASGRF1: Method= MI:0006;;MI:0006 PMID= 16753148;;16753148 CCAR1: Method= MI:0004 PMID= 18382127 CA11: Method= MI:0004 PMID= 18382127 HIPK2: Method= MI:0493;;MI:0096;;MI:0096;;MI:0018;;MI:0006;;MI:0096;;MI:0006;;MI:0096;;MI:0493;;MI:0096;;MI:0096 PMID= 16343438;;16212962;;11740489;;11925430;;15896780;;16212962;;15896780;;11740489;;11925430;;11740489;;11740489 YBX1: Method= MI:0493;;MI:0004;;MI:0096;;MI:0096 PMID= 11175333;;15136035;;11175333;;11175333 SMARCD1: Method= MI:0018;;MI:0018 PMID= 18303029;;18303029 ASPM: Method= MI:0004 PMID= 20308539 TRMT11: Method= MI:0004 PMID= 20308539 KLF6: Method= MI:0493 PMID= 15131018 TP53BP1: Method= MI:0114;;MI:0018;;MI:0114;;MI:0096;;MI:0004;;MI:0492;;MI:0018;;MI:0096;;MI:0004;;MI:0018;;MI:0114;;MI:0114;;MI:0004;;MI:0492 PMID= 11877378;;8016121;;12351827;;14978302;;15611139;;12110597;;8016121;;11877378;;15364958;;8016121;;11877378;;12110597;;15364958;;15364958 OTUD5: Method= MI:0007;;MI:0004 PMID= 19615732;;19615732 CDC42: Method= MI:0018;;MI:0492;;MI:0398 PMID= 16169070;;16169070;;16169070 XRCC1: Method= MI:0004;;MI:0096;;MI:0096;;MI:0096;;MI:0096;;MI:0096;;MI:0096 PMID= 15044383;;15044383;;15044383;;15044383;;15044383;;15044383;;15044383 TP63: Method= MI:0006;;MI:0493;;MI:0006;;MI:0006;;MI:0006 PMID= 19345189;;11238924;;19345189;;19345189;;19345189 PTGS2: Method= MI:0493;;MI:0004 PMID= 11687965;;11687965 TSG101: Method= MI:0004;;MI:0493;;MI:0004 PMID= 11172000;;11172000;;11172000 TOP2B: Method= MI:0004;;MI:0493;;MI:0004 PMID= 10666337;;10666337;;10666337 UBE2A: Method= MI:0004;;MI:0416;;MI:0004;;MI:0493 PMID= 12640129;;12640129;;12640129;;12640129 PIAS2: Method= MI:0096;;MI:0018;;MI:0018;;MI:0096;;MI:0663 PMID= 11867732;;19901969;;19901969;;11867732;;18624398 UBE2K: Method= MI:0493 PMID= 10634809 PPP2R5C: Method= MI:0006;;MI:0006 PMID= 17245430;;17245430 ITCH: Method= MI:0004 PMID= 18559494 TP73: Method= MI:0493 PMID= 11238924 CDC14A: Method= MI:0018;;MI:0018;;MI:0493;;MI:0018 PMID= 10644693;;10644693;;10644693;;10644693 PAFAH1B3: Method= MI:0492;;MI:0018;;MI:0398;;MI:0018;;MI:0018 PMID= 16169070;;16169070;;16169070;;16169070;;16169070 HSP90AA1: Method= MI:0493;;MI:0004;;MI:0004;;MI:0004 PMID= 11507088;;11507088;;12427754;;11297531 CDC14B: Method= MI:0018;;MI:0018;;MI:0493 PMID= 10644693;;10644693;;10644693 GSK3B: Method= MI:0027;;MI:0493;;MI:0027;;MI:0027;;MI:0004;;MI:0027;;MI:0004 PMID= 14744935;;12048243;;14744935;;14744935;;12048243;;14744935;;12048243 XPO1: Method= MI:0006;;MI:0006;;MI:0006 PMID= 17268548;;18952844;;17268548 KAT6A: Method= MI:0004;;MI:0004;;MI:0004 PMID= 19001415;;19001415;;19001415 TAF9: Method= MI:0096;;MI:0004 PMID= 7761466;;18250150 HUWE1: Method= MI:0007;;MI:0007;;MI:0492;;MI:0007 PMID= 15989956;;15989956;;15989956;;15989956 TFAP2C: Method= MI:0493;;MI:0428 PMID= 12226108;;12226108 AURKA: Method= MI:0018;;MI:0492;;MI:0018;;MI:0096;;MI:0096;;MI:0096;;MI:0018;;MI:0018;;MI:0018;;MI:0096 PMID= 12198151;;12198151;;12198151;;14702041;;14702041;;14702041;;12198151;;12198151;;12198151;;14702041 MAPKAPK5: Method= MI:0424;;MI:0424;;MI:0424;;MI:0492;;MI:0424 PMID= 17254968;;17254968;;17254968;;17254968;;17254968 APOH: Method= MI:0663 PMID= 18624398 ESR1: Method= MI:0492;;MI:0096 PMID= 10766163;;10766163 EIF2C1: Method= MI:0004 PMID= 20308539 MSH2: Method= MI:0004;;MI:0004;;MI:0493 PMID= 12101417;;12101417;;15064730 HSP90AB1: Method= MI:0493 PMID= 11707401 SIRT1: Method= MI:0493;;MI:0004 PMID= 11672523;;18235502 ABL1: Method= MI:0493;;MI:0096 PMID= 10713716;;10629029 SMARCB1: Method= MI:0096;;MI:0096;;MI:0096;;MI:0493;;MI:0096 PMID= 11950834;;11950834;;11950834;;11950834;;11950834 MAPK1: Method= MI:0493;;MI:0004 PMID= 11409876;;10958792 EP300: Method= MI:0096;;MI:0493;;MI:0415;;MI:0096;;MI:0096;;MI:0096;;MI:0096;;MI:0096;;MI:0096;;MI:0415;;MI:0004;;MI:0006;;MI:0004;;MI:0096;;MI:0006;;MI:0415;;MI:0006;;MI:0004;;MI:0096;;MI:0004;;MI:0071;;MI:0006;;MI:0415;;MI:0004;;MI:0019;;MI:0004;;MI:0006;;MI:0096;;MI:0019;;MI:0006;;MI:0004;;MI:0493;;MI:0006 PMID= 9809062;;16438982;;18485870;;11907332;;15186775;;11782467;;9809062;;9809062;;11782467;;18485870;;15542844;;10518217;;16024799;;11907332;;15542844;;19805293;;16782091;;17452980;;9809062;;16537920;;11070080;;10.1038/emboj.2009.83;;18485870;;16678111;;16611888;;18612383;;10.1038/emboj.2009.83;;15295102;;16611888;;16782091;;17977830;;16782091;;9194564 FKBP3: Method= MI:0096 PMID= 19166840 ERH: Method= MI:0492;;MI:0398;;MI:0018;;MI:0018;;MI:0018 PMID= 16169070;;16169070;;16169070;;16169070;;16169070 HIF1A: Method= MI:0004;;MI:0096;;MI:0004;;MI:0004;;MI:0492;;MI:0096 PMID= 10640274;;12606552;;9537326;;9537326;;12124396;;12124396 VRK1: Method= MI:0004;;MI:0415;;MI:0006;;MI:0493;;MI:0004;;MI:0004 PMID= 15542844;;10951572;;15542844;;10747897;;15542844;;15542844 YY1: Method= MI:0401;;MI:0096;;MI:0096;;MI:0004;;MI:0004;;MI:0004 PMID= 18026119;;15295102;;15295102;;15210108;;15210108;;15210108 APEX1: Method= MI:0493;;MI:0401 PMID= 9119221;;9119221 CHD8: Method= MI:0004 PMID= 19151705 NFKBIA: Method= MI:0004;;MI:0004;;MI:0493 PMID= 11799106;;11799106;;11799106 HNF4A: Method= MI:0096;;MI:0492 PMID= 11818510;;11818510 STK4: Method= MI:0493 PMID= 12384512 CSNK2A1: Method= MI:0493 PMID= 10747897 MYL9: Method= MI:0004 PMID= 20308539 E2F1: Method= MI:0493 PMID= 11739724 PSMD10: Method= MI:0004 PMID= 16023600 POLA1: Method= MI:0004;;MI:0493 PMID= 11917009;;11917009 BMX: Method= MI:0006;;MI:0006;;MI:0006 PMID= 16186805;;16186805;;16186805 USP11: Method= MI:0004;;MI:0007 PMID= 19615732;;19615732 CD40LG: Method= MI:0493 PMID= 12011072 MAPK3: Method= MI:0493;;MI:0004 PMID= 10958792;;10958792 NPRL3: Method= MI:0004 PMID= 20308539 TAF1C: Method= MI:0492;;MI:0096 PMID= 10913176;;10913176 MTHFSD: Method= MI:0004 PMID= 20308539 FAM173A: Method= MI:0492;;MI:0398;;MI:0018 PMID= 16169070;;16169070;;16169070 STUB1: Method= MI:0004 PMID= 18223694 UBE2I: Method= MI:0007;;MI:0007;;MI:0415;;MI:0018;;MI:0018;;MI:0018;;MI:0018;;MI:0663;;MI:0018;;MI:0007;;MI:0007 PMID= 15327968;;15327968;;11853669;;8921390;;10961991;;10380882;;8921390;;18624398;;8921390;;15327968;;15327968 KAT8: Method= MI:0006;;MI:0415;;MI:0004;;MI:0004;;MI:0006 PMID= 16601686;;17189187;;19854137;;15960975;;16601686 IKBKB: Method= MI:0006;;MI:0006 PMID= 19883646;;19883646 PPP1R13L: Method= MI:0065;;MI:0004;;MI:0492 PMID= 18275817;;12524540;;12524540 ERCC2: Method= MI:0096 PMID= 7663514 PIAS4: Method= MI:0018;;MI:0018;;MI:0018 PMID= 15383276;;11388671;;11388671 HNRNPUL1: Method= MI:0493;;MI:0096;;MI:0006;;MI:0006;;MI:0096;;MI:0006;;MI:0096;;MI:0096;;MI:0096;;MI:0006;;MI:0006;;MI:0096;;MI:0096;;MI:0006;;MI:0096;;MI:0006;;MI:0006;;MI:0006;;MI:0006;;MI:0096;;MI:0096;;MI:0096;;MI:0096;;MI:0006;;MI:0096;;MI:0096 PMID= 15907477;;15907477;;15907477;;15907477;;15907477;;15907477;;15907477;;15907477;;15907477;;15907477;;15907477;;15907477;;15907477;;15907477;;15907477;;15907477;;15907477;;15907477;;15907477;;15907477;;15907477;;15907477;;15907477;;15907477;;15907477;;15907477 PPP2R1A: Method= MI:0006;;MI:0006;;MI:0006;;MI:0006 PMID= 17245430;;17245430;;17245430;;17245430 ELL: Method= MI:0493;;MI:0018;;MI:0018;;MI:0018;;MI:0018;;MI:0018 PMID= 10358050;;10358050;;10358050;;10358050;;10358050;;10358050 ETHE1: Method= MI:0004;;MI:0004 PMID= 17353187;;17353187 DNAJB6: Method= MI:0004 PMID= 20308539 HSPB1: Method= MI:0018;;MI:0492;;MI:0398;;MI:0018;;MI:0006;;MI:0006;;MI:0018;;MI:0493 PMID= 16169070;;16169070;;16169070;;16169070;;17184779;;17184779;;16169070;;17184779 TAF6: Method= MI:0096;;MI:0071;;MI:0096;;MI:0096 PMID= 20096117;;7809597;;20096117;;20096117 AIMP2: Method= MI:0004;;MI:0004;;MI:0004;;MI:0004;;MI:0006;;MI:0006 PMID= 18695251;;18695251;;18695251;;18695251;;18695251;;18695251 ZNHIT1: Method= MI:0492 PMID= 17380123 BAG1: Method= MI:0096 PMID= 9582267 MAPK8: Method= MI:0493;;MI:0006;;MI:0096;;MI:0096;;MI:0006;;MI:0415;;MI:0493 PMID= 15580310;;15580310;;15538975;;15538975;;15580310;;9393873;;9732264 GTPBP4: Method= MI:0004 PMID= 20308539 ZMIZ1: Method= MI:0018;;MI:0018;;MI:0018 PMID= 17584785;;17584785;;17584785 TADA2A: Method= MI:0004 PMID= 18250150 KPNB1: Method= MI:0004;;MI:0004;;MI:0493 PMID= 11297531;;11297531;;11297531 SMARCD2: Method= MI:0004 PMID= 20308539 DDX5: Method= MI:0493 PMID= 15660129 PSMD11: Method= MI:0492;;MI:0018;;MI:0018;;MI:0398;;MI:0018 PMID= 16169070;;16169070;;16169070;;16169070;;16169070 KAT2A: Method= MI:0004 PMID= 18250150 YWHAE: Method= MI:0053;;MI:0053;;MI:0053;;MI:0053;;MI:0053;;MI:0053 PMID= 18812399;;18812399;;18812399;;18812399;;18812399;;18812399 DPH1: Method= MI:0004 PMID= 20308539 SULT1E1: Method= MI:0018;;MI:0492;;MI:0398;;MI:0018;;MI:0018 PMID= 16169070;;16169070;;16169070;;16169070;;16169070 MAPK10: Method= MI:0415;;MI:0493 PMID= 9393873;;9393873 HSPA8: Method= MI:0004 PMID= 11297531 HIPK3: Method= MI:0018 PMID= 10961991 GTF2H1: Method= MI:0077;;MI:0077;;MI:0096;;MI:0077;;MI:0077;;MI:0492;;MI:0077;;MI:0077;;MI:0077;;MI:0077;;MI:0077;;MI:0077 PMID= 18354501;;18354501;;7935417;;18354501;;18354501;;7935417;;18354501;;18354501;;18354501;;18354501;;18354501;;18354501 VDR: Method= MI:0416;;MI:0416;;MI:0416;;MI:0416;;MI:0416 PMID= 20227041;;20227041;;20227041;;20227041;;20227041 COPS7A: Method= MI:0492;;MI:0492 PMID= 11285227;;11285227 ING4: Method= MI:0019;;MI:0004;;MI:0493;;MI:0004;;MI:0019;;MI:0004;;MI:0004;;MI:0004;;MI:0004 PMID= 15251430;;12750254;;12750254;;15882981;;15251430;;18775696;;15882981;;17954561;;12750254 ASF1A: Method= MI:0004 PMID= 20308539 PHF1: Method= MI:0004;;MI:0004 PMID= 18385154;;18385154 TBP: Method= MI:0047;;MI:0004;;MI:0047;;MI:0096;;MI:0004;;MI:0096;;MI:0096;;MI:0492 PMID= 7799929;;11313951;;7799929;;1465435;;10359315;;9349482;;9349482;;1465435 CUL9: Method= MI:0018;;MI:0004;;MI:0004;;MI:0004;;MI:0004;;MI:0492;;MI:0004;;MI:0018;;MI:0004 PMID= 18230339;;12526791;;12526791;;12526791;;12526791;;12526791;;12526791;;18230339;;17380154 LAMA4: Method= MI:0018;;MI:0492;;MI:0398 PMID= 16169070;;16169070;;16169070 BRD8: Method= MI:0004 PMID= 20308539 HSPA9: Method= MI:0004;;MI:0004;;MI:0004;;MI:0006;;MI:0004;;MI:0004;;MI:0096;;MI:0096;;MI:0493;;MI:0006;;MI:0004;;MI:0493 PMID= 20153329;;20153329;;20153329;;17184779;;20153329;;20153329;;11900485;;11900485;;11900485;;17184779;;20153329;;17184779 CCNG1: Method= MI:0004;;MI:0493;;MI:0096;;MI:0096 PMID= 12642871;;12556559;;12556559;;12556559 PPP2CA: Method= MI:0493 PMID= 12556559 NR3C1: Method= MI:0493;;MI:0004;;MI:0096;;MI:0096;;MI:0096;;MI:0493 PMID= 11080152;;11080152;;11562347;;11562347;;11562347;;11562347 CSNK1A1: Method= MI:0492 PMID= 9765199 UBE3A: Method= MI:0107;;MI:0107;;MI:0096;;MI:0096;;MI:0493 PMID= 16493710;;16493710;;12620801;;12620801;;9369221 KAT2B: Method= MI:0006;;MI:0006;;MI:0004;;MI:0415;;MI:0004;;MI:0018;;MI:0004 PMID= 16959611;;16959611;;16678111;;12068014;;16537920;;9744860;;17977830 WDR48: Method= MI:0004;;MI:0007 PMID= 19615732;;19615732 NCL: Method= MI:0493;;MI:0004;;MI:0004;;MI:0004 PMID= 12138209;;12138209;;12138209;;12138209 TAF1B: Method= MI:0096;;MI:0492 PMID= 10913176;;10913176 CEBPZ: Method= MI:0493;;MI:0006;;MI:0006;;MI:0004;;MI:0006;;MI:0006;;MI:0004 PMID= 12534345;;12534345;;12534345;;12534345;;12534345;;12534345;;12534345 ARID3A: Method= MI:0493 PMID= 12136662 SUMO1: Method= MI:0492;;MI:0004;;MI:0808;;MI:0096;;MI:0096;;MI:0018;;MI:0004 PMID= 15931224;;12917636;;16732283;;11867732;;18583933;;10961991;;17369817 DHCR24: Method= MI:0493 PMID= 15577914 HDAC1: Method= MI:0006;;MI:0006;;MI:0006;;MI:0004;;MI:0006;;MI:0004;;MI:0004;;MI:0006;;MI:0096;;MI:0096;;MI:0493;;MI:0006;;MI:0096;;MI:0004;;MI:0006;;MI:0004;;MI:0004;;MI:0006;;MI:0004;;MI:0096;;MI:0004;;MI:0004;;MI:0006;;MI:0004 PMID= 16959611;;16959611;;10.1038/emboj.2009.395;;18765668;;10.1038/emboj.2009.395;;14976551;;16697957;;10.1038/emboj.2009.395;;10777477;;10777477;;10777477;;10.1038/emboj.2009.395;;11099047;;16107876;;16959611;;10521394;;17827154;;10.1038/emboj.2009.395;;19011633;;10777477;;11313951;;11313951;;10.1038/emboj.2009.395;;12426395 RBBP5: Method= MI:0004 PMID= 15960975 CR2: Method= MI:0492 PMID= 7753047 STK11: Method= MI:0493;;MI:0004 PMID= 11430832;;11430832 MLL: Method= MI:0004 PMID= 15960975 CREB1: Method= MI:0096;;MI:0096;;MI:0096 PMID= 10848610;;10848610;;10848610 PLAGL1: Method= MI:0492;;MI:0096;;MI:0096 PMID= 11360197;;11360197;;11360197 TTLL5: Method= MI:0004 PMID= 20308539 SUPT7L: Method= MI:0004 PMID= 18250150 KANSL1: Method= MI:0004 PMID= 19854137 EGR1: Method= MI:0027;;MI:0027;;MI:0004;;MI:0004;;MI:0492 PMID= 14744935;;14744935;;11251186;;11251186;;11251186 NFYB: Method= MI:0006;;MI:0006;;MI:0006;;MI:0006;;MI:0006;;MI:0493;;MI:0004 PMID= 16959611;;16959611;;16959611;;16959611;;16959611;;16959611;;15831478 COPS5: Method= MI:0492;;MI:0004;;MI:0492;;MI:0004;;MI:0004;;MI:0004 PMID= 11285227;;16936264;;11285227;;17879958;;17879958;;17879958 RPL5: Method= MI:0493;;MI:0004;;MI:0004 PMID= 7935455;;15308643;;15308643 ZMIZ2: Method= MI:0018 PMID= 17584785 KIAA0087: Method= MI:0018;;MI:0398;;MI:0018 PMID= 16169070;;16169070;;16169070 CDKN2C: Method= MI:0018;;MI:0018;;MI:0398;;MI:0492;;MI:0018 PMID= 16169070;;16169070;;16169070;;16169070;;16169070 NR4A1: Method= MI:0493;;MI:0493;;MI:0007;;MI:0007;;MI:0007;;MI:0007;;MI:0007;;MI:0007;;MI:0004;;MI:0007;;MI:0007;;MI:0007;;MI:0007;;MI:0004;;MI:0007;;MI:0493;;MI:0004;;MI:0007 PMID= 17139261;;17139261;;17139261;;17139261;;17139261;;17139261;;17139261;;17139261;;17139261;;17139261;;17139261;;17139261;;17139261;;17139261;;17139261;;17139261;;17139261;;17139261 CDK2: Method= MI:0493;;MI:0415 PMID= 10884347;;10884347 EIF2C2: Method= MI:0004 PMID= 20308539 CSE1L: Method= MI:0030;;MI:0030;;MI:0030;;MI:0030;;MI:0030 PMID= 17719542;;17719542;;17719542;;17719542;;17719542 SNAI1: Method= MI:0006;;MI:0006;;MI:0006;;MI:0006 PMID= 20385133;;20385133;;20385133;;20385133 NQO2: Method= MI:0004 PMID= 17545619 MAD2L1BP: Method= MI:0018;;MI:0018;;MI:0018;;MI:0398;;MI:0492 PMID= 16169070;;16169070;;16169070;;16169070;;16169070 CDKN1A: Method= MI:0004;;MI:0006;;MI:0006;;MI:0493 PMID= 11896572;;16616141;;16616141;;17139261 PIWIL1: Method= MI:0004 PMID= 20308539 MED1: Method= MI:0006;;MI:0006;;MI:0006;;MI:0096;;MI:0004;;MI:0493;;MI:0006;;MI:0004;;MI:0006;;MI:0006 PMID= 15848166;;15848166;;15848166;;9444950;;9444950;;11118038;;15848166;;11118038;;15848166;;15848166 RPL23: Method= MI:0004;;MI:0004 PMID= 15308643;;15308643 EIF2S2: Method= MI:0492;;MI:0018;;MI:0018;;MI:0398;;MI:0018 PMID= 16169070;;16169070;;16169070;;16169070;;16169070 PRMT1: Method= MI:0096;;MI:0492 PMID= 15186775;;15186775 PIN1: Method= MI:0096;;MI:0096;;MI:0096;;MI:0096;;MI:0096;;MI:0096;;MI:0096;;MI:0096;;MI:0493;;MI:0096;;MI:0096;;MI:0096;;MI:0096 PMID= 12397362;;12397362;;12397362;;12397362;;12397362;;12397362;;12397361;;12397361;;12397362;;12397361;;12397361;;12388558;;12388558 SMARCA4: Method= MI:0004;;MI:0096;;MI:0493;;MI:0096;;MI:0096;;MI:0018;;MI:0006 PMID= 17666433;;11950834;;11950834;;11950834;;11950834;;18303029;;18303029 SNRPN: Method= MI:0492;;MI:0398;;MI:0018 PMID= 16169070;;16169070;;16169070 NEDD8: Method= MI:0004;;MI:0004;;MI:0493;;MI:0004;;MI:0004 PMID= 16620772;;17098746;;16620772;;17546054;;17369817 TEP1: Method= MI:0096;;MI:0493 PMID= 10597287;;10597287 SAT1: Method= MI:0018;;MI:0398;;MI:0018;;MI:0492;;MI:0018 PMID= 16169070;;16169070;;16169070;;16169070;;16169070 DNMT1: Method= MI:0004 PMID= 17991895 HABP4: Method= MI:0018;;MI:0018;;MI:0018;;MI:0018 PMID= 16455055;;16455055;;16455055;;16455055 PSME3: Method= MI:0004;;MI:0004;;MI:0492;;MI:0006;;MI:0004;;MI:0006;;MI:0006;;MI:0006;;MI:0006;;MI:0006;;MI:0006;;MI:0006;;MI:0006;;MI:0006;;MI:0006;;MI:0006;;MI:0006;;MI:0006;;MI:0006;;MI:0006;;MI:0006;;MI:0492;;MI:0006 PMID= 18309296;;18309296;;18309296;;18309296;;18309296;;18309296;;18309296;;18309296;;18309296;;18309296;;18309296;;18309296;;18309296;;18309296;;18309296;;18309296;;18309296;;18309296;;18309296;;18309296;;18309296;;18309296;;18309296 MAP1B: Method= MI:0006;;MI:0006;;MI:0006;;MI:0006;;MI:0006;;MI:0006;;MI:0006;;MI:0006;;MI:0006;;MI:0006;;MI:0006;;MI:0006 PMID= 18656471;;18656471;;18656471;;18656471;;18656471;;18656471;;18656471;;18656471;;18656471;;18656471;;18656471;;18656471 TOP2A: Method= MI:0004;;MI:0493;;MI:0004 PMID= 10666337;;10666337;;10666337 RPA1: Method= MI:0004;;MI:0493;;MI:0018;;MI:0096;;MI:0096;;MI:0411 PMID= 11751427;;11751427;;8663296;;15489903;;15489903;;15735006 GPS2: Method= MI:0493;;MI:0004;;MI:0004 PMID= 11486030;;11486030;;11486030 TOE1: Method= MI:0006;;MI:0006;;MI:0006;;MI:0006;;MI:0006;;MI:0006 PMID= 19508870;;19508870;;19508870;;19508870;;19508870;;19508870 TPT1: Method= MI:0006;;MI:0006;;MI:0006;;MI:0006;;MI:0006;;MI:0006;;MI:0006;;MI:0006;;MI:0006;;MI:0006 PMID= 21081126;;21081126;;21081126;;21081126;;21081126;;21081126;;21081126;;21081126;;21081126;;21081126 BTBD2: Method= MI:0018;;MI:0398;;MI:0018;;MI:0492;;MI:0018;;MI:0398 PMID= 16169070;;16169070;;16169070;;16169070;;16169070;;16169070 PRAM1: Method= MI:0004 PMID= 14976551 MKRN1: Method= MI:0096;;MI:0096;;MI:0096;;MI:0096;;MI:0096;;MI:0096;;MI:0096;;MI:0096;;MI:0096;;MI:0096;;MI:0096;;MI:0096;;MI:0096;;MI:0096;;MI:0096;;MI:0096 PMID= 10.1038/emboj.2009.164;;10.1038/emboj.2009.164;;10.1038/emboj.2009.164;;10.1038/emboj.2009.164;;10.1038/emboj.2009.164;;10.1038/emboj.2009.164;;10.1038/emboj.2009.164;;10.1038/emboj.2009.164;;10.1038/emboj.2009.164;;10.1038/emboj.2009.164;;10.1038/emboj.2009.164;;10.1038/emboj.2009.164;;10.1038/emboj.2009.164;;10.1038/emboj.2009.164;;10.1038/emboj.2009.164;;10.1038/emboj.2009.164 DUSP26: Method= MI:0006;;MI:0006;;MI:0006;;MI:0006;;MI:0006;;MI:0006;;MI:0006;;MI:0006;;MI:0006 PMID= 20562916;;20562916;;20562916;;20562916;;20562916;;20562916;;20562916;;20562916;;20562916 MEN1: Method= MI:0004 PMID= 15960975 NUMB: Method= MI:0004;;MI:0004 PMID= 18172499;;18172499 CDK7: Method= MI:0415;;MI:0047;;MI:0493 PMID= 9372954;;9840937;;9840937 VHL: Method= MI:0004;;MI:0004;;MI:0004 PMID= 16678111;;16678111;;16678111 BHLHE40: Method= MI:0428;;MI:0428;;MI:0428;;MI:0428;;MI:0428;;MI:0428;;MI:0428;;MI:0428;;MI:0428;;MI:0428 PMID= 17347673;;17347673;;17347673;;17347673;;17347673;;17347673;;17347673;;17347673;;17347673;;17347673 CCNH: Method= MI:0047;;MI:0047;;MI:0493 PMID= 9840937;;9840937;;9840937 CABLES1: Method= MI:0492;;MI:0004;;MI:0019 PMID= 14637168;;14637168;;11706030 TEC: Method= MI:0492 PMID= 15355990 MDM2: Method= MI:0007;;MI:0007;;MI:0007;;MI:0007;;MI:0492;;MI:0493;;MI:0493;;MI:0006;;MI:0411;;MI:0006;;MI:0006;;MI:0493;;MI:0493;;MI:0493;;MI:0493;;MI:0493;;MI:0004;;MI:0004;;MI:0004;;MI:0415;;MI:0096;;MI:0415;;MI:0004;;MI:0004;;MI:0004;;MI:0004;;MI:0004;;MI:0006;;MI:0004;;MI:0096;;MI:0411;;MI:0096;;MI:0018;;MI:0428;;MI:0096;;MI:0006;;MI:0006;;MI:0096;;MI:0096;;MI:0004;;MI:0428;;MI:0018;;MI:0401;;MI:0006;;MI:0006;;MI:0096;;MI:0096;;MI:0096;;MI:0006;;MI:0065;;MI:0415;;MI:0416;;MI:0004;;MI:0006;;MI:0096;;MI:0096;;MI:0006;;MI:0004;;MI:0004;;MI:0007;;MI:0007;;MI:0107;;MI:0007;;MI:0007;;MI:0006;;MI:0004;;MI:0415;;MI:0007;;MI:0428;;MI:0071;;MI:0006;;MI:0096;;MI:0018;;MI:0004;;MI:0004;;MI:0415;;MI:0004;;MI:0096;;MI:0096;;MI:0004;;MI:0004;;MI:0007;;MI:0114;;MI:0096;;MI:0004;;MI:0006;;MI:0004;;MI:0114;;MI:0107;;MI:0004;;MI:0071;;MI:0007;;MI:0096;;MI:0096;;MI:0004;;MI:0004;;MI:0096;;MI:0007;;MI:0428;;MI:0428;;MI:0007;;MI:0007;;MI:0428;;MI:0071;;MI:0004;;MI:0090;;MI:0415;;MI:0071;;MI:0004;;MI:0004;;MI:0004;;MI:0007;;MI:0004;;MI:0096;;MI:0007;;MI:0411;;MI:0004;;MI:0007;;MI:0007;;MI:0004;;MI:0096;;MI:0004;;MI:0004;;MI:0004;;MI:0096;;MI:0096;;MI:0004;;MI:0004;;MI:0096;;MI:0004;;MI:0096;;MI:0004;;MI:0428;;MI:0004;;MI:0004;;MI:0018;;MI:0018;;MI:0493;;MI:0415;;MI:0004;;MI:0004;;MI:0018;;MI:0004;;MI:0004;;MI:0004;;MI:0004;;MI:0004;;MI:0006;;MI:0006;;MI:0004;;MI:0114;;MI:0004;;MI:0004;;MI:0004;;MI:0415;;MI:0415;;MI:0096;;MI:0493;;MI:0006;;MI:0006;;MI:0006;;MI:0006;;MI:0006;;MI:0006;;MI:0006;;MI:0492;;MI:0006;;MI:0006;;MI:0006;;MI:0006;;MI:0006 PMID= 19098711;;19098711;;19098711;;19098711;;18632619;;17139261;;18566590;;15144954;;17875722;;12915590;;12915590;;10078201;;11562347;;18382127;;18566590;;17139261;;17470788;;11709713;;12620407;;14671306;;7686617;;18485870;;21454483;;11925449;;12612087;;11925449;;15308643;;15848166;;15542844;;16212962;;17875722;;16212962;;19166840;;12915590;;12915590;;15848166;;15848166;;12915590;;16579792;;16964247;;12915590;;11178989;;7926727;;18309296;;17268548;;16212962;;11384992;;16212962;;18309296;;19255450;;18485870;;20708156;;14612427;;15848166;;17525743;;14702041;;12915590;;12426395;;12426395;;19098711;;19098711;;14704432;;17139261;;17139261;;18309296;;15122315;;18665269;;17159902;;17347673;;20591429;;17268548;;11562347;;19166840;;15308643;;16107876;;10722742;;17098746;;14596917;;10196247;;17936559;;11431470;;17159902;;15154850;;15295102;;14612427;;18309296;;19223463;;15154850;;14704432;;16547496;;20591429;;17139261;;18332869;;18332869;;18172499;;18172499;;16866370;;17139261;;12915590;;12915590;;19098711;;19098711;;17347673;;20591429;;12167711;;15908921;;16857591;;20591429;;15064742;;17908790;;17908790;;19098711;;19085961;;9809062;;19098711;;17875722;;10892746;;19098711;;19098711;;17139261;;19166840;;17139261;;12208736;;19071110;;10766163;;9271120;;17369817;;16624812;;10196247;;15210108;;19303885;;12944468;;11744695;;16023600;;16023600;;9529249;;9529249;;16432196;;18485870;;21454483;;18309296;;10608892;;21454483;;19098711;;18172499;;17591690;;18223694;;19411066;;19411066;;15933712;;8875929;;17380154;;17363365;;11713288;;18485870;;18485870;;19188367;;7935455;;18309296;;18309296;;18309296;;18309296;;18309296;;18309296;;18309296;;18309296;;18309296;;17310983;;17310983;;18952844;;18952844 MPHOSPH6: Method= MI:0018;;MI:0492;;MI:0398;;MI:0018;;MI:0018 PMID= 16169070;;16169070;;16169070;;16169070;;16169070 TAF5L: Method= MI:0004 PMID= 18250150 NMT1: Method= MI:0006;;MI:0006;;MI:0493 PMID= 16530191;;16530191;;16530191 KAT7: Method= MI:0004;;MI:0004;;MI:0004 PMID= 17954561;;17954561;;17954561 WDR33: Method= MI:0018;;MI:0492;;MI:0398 PMID= 16169070;;16169070;;16169070 CDK9: Method= MI:0492 PMID= 16552184 TXN: Method= MI:0096 PMID= 19681600 KLF4: Method= MI:0493 PMID= 10749849 DAB2IP: Method= MI:0004 PMID= 20308539 APTX: Method= MI:0096;;MI:0096;;MI:0004;;MI:0004 PMID= 15044383;;15044383;;15044383;;15044383 RNF38: Method= MI:0004 PMID= 20308539 TFAP2A: Method= MI:0428;;MI:0428;;MI:0428;;MI:0493;;MI:0428 PMID= 12226108;;12226108;;12226108;;12226108;;12226108 MDC1: Method= MI:0004;;MI:0493 PMID= 14519663;;14519663 PRKRIR: Method= MI:0004 PMID= 12384512 FXYD6: Method= MI:0492;;MI:0398;;MI:0018;;MI:0018;;MI:0018 PMID= 16169070;;16169070;;16169070;;16169070;;16169070 FBXO11: Method= MI:0096;;MI:0004;;MI:0493;;MI:0004;;MI:0004;;MI:0096;;MI:0096 PMID= 17098746;;17098746;;17098746;;17098746;;17098746;;17098746;;17098746 LRPPRC: Method= MI:0004 PMID= 20308539 ARL3: Method= MI:0398;;MI:0018;;MI:0018;;MI:0492;;MI:0018 PMID= 16169070;;16169070;;16169070;;16169070;;16169070 BARD1: Method= MI:0401;;MI:0006;;MI:0493;;MI:0401;;MI:0004 PMID= 14636569;;15782130;;15782130;;14636569;;15782130 HECW2: Method= MI:0004 PMID= 12890487 COX17: Method= MI:0018;;MI:0018;;MI:0018;;MI:0492;;MI:0398 PMID= 16169070;;16169070;;16169070;;16169070;;16169070 COPS4: Method= MI:0492;;MI:0492 PMID= 11285227;;11285227 ANXA3: Method= MI:0492;;MI:0398;;MI:0018;;MI:0018;;MI:0018 PMID= 16169070;;16169070;;16169070;;16169070;;16169070 TDG: Method= MI:0018 PMID= 10961991 BRCA2: Method= MI:0004;;MI:0401;;MI:0401;;MI:0401;;MI:0493;;MI:0019 PMID= 9811893;;14636569;;14636569;;14636569;;9811893;;9811893 NCOA2: Method= MI:0676 PMID= 20195357 PML: Method= MI:0006;;MI:0006;;MI:0096;;MI:0006;;MI:0004;;MI:0493;;MI:0004;;MI:0004;;MI:0004;;MI:0004;;MI:0428;;MI:0428;;MI:0096;;MI:0428;;MI:0428 PMID= 12915590;;12915590;;12915590;;12915590;;11025664;;11704853;;11025664;;11080164;;14976551;;11080164;;12915590;;12915590;;12915590;;12915590;;12915590 NOL3: Method= MI:0807 PMID= 18087040 NCOR1: Method= MI:0004 PMID= 19011633 COPS3: Method= MI:0492;;MI:0492 PMID= 11285227;;11285227 CSNK1D: Method= MI:0493 PMID= 9349507 SAE1: Method= MI:0007;;MI:0007 PMID= 15327968;;15327968 RPL11: Method= MI:0004;;MI:0004;;MI:0004;;MI:0004 PMID= 14612427;;15308643;;14612427;;15308643 SERBP1: Method= MI:0018 PMID= 16455055 RFWD2: Method= MI:0007;;MI:0007;;MI:0492;;MI:0004;;MI:0007;;MI:0007;;MI:0007;;MI:0007;;MI:0007;;MI:0007 PMID= 15103385;;15103385;;15103385;;16931761;;15103385;;15103385;;15103385;;15103385;;15103385;;15103385 TAF1A: Method= MI:0096;;MI:0492 PMID= 10913176;;10913176 SMYD2: Method= MI:0492;;MI:0004;;MI:0415;;MI:0415 PMID= 17108971;;18065756;;17108971;;17108971 TP53BP2: Method= MI:0114;;MI:0492;;MI:0065;;MI:0018;;MI:0018;;MI:0018;;MI:0114;;MI:0018;;MI:0018;;MI:0114;;MI:0114;;MI:0018;;MI:0018 PMID= 8875926;;8016121;;18275817;;8668206;;8668206;;8668206;;8875926;;8016121;;8016121;;8875926;;8875926;;8016121;;8016121 S100A8: Method= MI:0018;;MI:0018;;MI:0492;;MI:0398;;MI:0018 PMID= 16169070;;16169070;;16169070;;16169070;;16169070 ACTA1: Method= MI:0492 PMID= 11821948 PARP1: Method= MI:0004;;MI:0004;;MI:0047;;MI:0006;;MI:0096;;MI:0096;;MI:0493;;MI:0096;;MI:0096 PMID= 9312059;;15044383;;9565608;;14627987;;12898523;;12898523;;9565608;;12898523;;12898523 RPS27A: Method= MI:0006;;MI:0006 PMID= 18695251;;18695251 ANK2: Method= MI:0676 PMID= 20195357 CCNA2: Method= MI:0493;;MI:0415 PMID= 10884347;;10884347 SETD7: Method= MI:0415;;MI:0415;;MI:0415;;MI:0493;;MI:0415;;MI:0516;;MI:0415;;MI:0415;;MI:0415;;MI:0415;;MI:0515;;MI:0415;;MI:0415 PMID= 15525938;;15525938;;15525938;;15525938;;15525938;;16415881;;15525938;;15525938;;15525938;;15525938;;16415881;;15525938;;17108971 HDAC8: Method= MI:0114;;MI:0114 PMID= 17721440;;17721440 TAF1: Method= MI:0004 PMID= 10359315 CDKN2A: Method= MI:0018;;MI:0004;;MI:0018;;MI:0018;;MI:0004 PMID= 12446718;;14612427;;9529249;;9529249;;14612427 INPP5E: Method= MI:0004 PMID= 20308539 SERPINH1: Method= MI:0004 PMID= 17977830 ATM: Method= MI:0424;;MI:0045;;MI:0415;;MI:0045;;MI:0492;;MI:0096;;MI:0415;;MI:0096;;MI:0096;;MI:0686;;MI:0415;;MI:0096 PMID= 19015526;;10864201;;17409407;;10864201;;9765199;;9843217;;15064416;;9843217;;15632067;;10608806;;15064416;;15159397 MTA2: Method= MI:0004;;MI:0493;;MI:0096;;MI:0096;;MI:0096 PMID= 12920132;;11099047;;11099047;;11099047;;11099047 CHEK1: Method= MI:0004;;MI:0004;;MI:0019;;MI:0492;;MI:0004;;MI:0096;;MI:0019 PMID= 11896572;;15364958;;16511572;;11896572;;11896572;;12756247;;16511572 CABLES2: Method= MI:0004;;MI:0492 PMID= 14637168;;14637168 PPP4C: Method= MI:0018 PMID= 9837938 CCT5: Method= MI:0398;;MI:0018;;MI:0018;;MI:0492;;MI:0018 PMID= 16169070;;16169070;;16169070;;16169070;;16169070 UBC: Method= MI:0007;;MI:0007;;MI:0007;;MI:0107;;MI:0096;;MI:0006;;MI:0096;;MI:0007;;MI:0006;;MI:0006;;MI:0096;;MI:0007;;MI:0006;;MI:0006;;MI:0007;;MI:0096;;MI:0007;;MI:0006;;MI:0006;;MI:0107;;MI:0006;;MI:0006;;MI:0096;;MI:0007;;MI:0006;;MI:0096;;MI:0096;;MI:0096;;MI:0006;;MI:0006 PMID= 19098711;;17568776;;17568776;;19798103;;17290220;;18566590;;10.1038/emboj.2009.164;;19098711;;18309296;;17268548;;17170702;;17159902;;18309296;;19619542;;17139261;;17170702;;17159902;;19619542;;19619542;;19798103;;17268548;;19619542;;10.1038/emboj.2009.164;;17139261;;18566590;;17290220;;18388957;;18388957;;18566590;;18566590 THRB: Method= MI:0004;;MI:0045;;MI:0493 PMID= 11258898;;8633054;;11258898 TADA1: Method= MI:0004 PMID= 18250150 JMY: Method= MI:0006 PMID= 10518217 NMT2: Method= MI:0006;;MI:0493;;MI:0006 PMID= 16530191;;16530191;;16530191 ING1: Method= MI:0004;;MI:0004;;MI:0492;;MI:0004 PMID= 19085961;;9440695;;12208736;;12208736 PRKCA: Method= MI:0493 PMID= 9935181 UCHL1: Method= MI:0004 PMID= 18666234 ZCCHC10: Method= MI:0492;;MI:0018;;MI:0018;;MI:0398;;MI:0018 PMID= 16169070;;16169070;;16169070;;16169070;;16169070 RNF20: Method= MI:0096;;MI:0096;;MI:0402 PMID= 16337599;;16337599;;19410543 BACH1: Method= MI:0004;;MI:0004;;MI:0004 PMID= 19011633;;19011633;;19011633 PPP2R2B: Method= MI:0493 PMID= 17245430 BRE: Method= MI:0401;;MI:0401;;MI:0401 PMID= 14636569;;14636569;;14636569 CDC25C: Method= MI:0493 PMID= 10853038 DYNC1I1: Method= MI:0006;;MI:0006 PMID= 16616141;;16616141 IGF2BP1: Method= MI:0004 PMID= 20308539 PADI4: Method= MI:0004;;MI:0004;;MI:0004;;MI:0004;;MI:0004;;MI:0004 PMID= 18505818;;20190809;;18505818;;18505818;;18505818;;18505818 S100B: Method= MI:0071;;MI:0004;;MI:0071;;MI:0071;;MI:0004;;MI:0071;;MI:0492 PMID= 20591429;;15178678;;20591429;;20591429;;15178678;;20591429;;11527429 S100A1: Method= MI:0071;;MI:0071;;MI:0071;;MI:0071 PMID= 20591429;;20591429;;20591429;;20591429 THAP8: Method= MI:0492;;MI:0018;;MI:0398;;MI:0018;;MI:0018 PMID= 16169070;;16169070;;16169070;;16169070;;16169070 ZNF385A: Method= MI:0006 PMID= 17719541 STX5: Method= MI:0492;;MI:0018;;MI:0018;;MI:0398;;MI:0018 PMID= 16169070;;16169070;;16169070;;16169070;;16169070 SYVN1: Method= MI:0096;;MI:0493;;MI:0096;;MI:0096;;MI:0096;;MI:0096;;MI:0096;;MI:0096;;MI:0096;;MI:0096;;MI:0096 PMID= 17170702;;17170702;;17170702;;17170702;;17170702;;17170702;;17170702;;17170702;;17170702;;17170702;;17170702 ATF3: Method= MI:0004;;MI:0004;;MI:0492;;MI:0398;;MI:0004;;MI:0004;;MI:0018;;MI:0004 PMID= 11792711;;11792711;;11792711;;16169070;;15933712;;15933712;;16169070;;15933712 MSX1: Method= MI:0493 PMID= 15705871 ERCC3: Method= MI:0492;;MI:0096;;MI:0096 PMID= 7663514;;7663514;;7663514 HIPK1: Method= MI:0018;;MI:0006;;MI:0018;;MI:0006;;MI:0493;;MI:0018 PMID= 12702766;;12702766;;12702766;;12702766;;12702766;;12702766 MNDA: Method= MI:0492 PMID= 16458891 IFI16: Method= MI:0004;;MI:0493 PMID= 11146555;;11146555 RYBP: Method= MI:0007;;MI:0007;;MI:0007;;MI:0007;;MI:0004 PMID= 19098711;;19098711;;19098711;;19098711;;19098711 RCHY1: Method= MI:0007;;MI:0007;;MI:0007;;MI:0007;;MI:0096;;MI:0007;;MI:0007;;MI:0004;;MI:0007;;MI:0004;;MI:0808;;MI:0096;;MI:0007;;MI:0007;;MI:0007;;MI:0493 PMID= 17568776;;17568776;;17568776;;17568776;;19043414;;17568776;;17568776;;12654245;;17568776;;12654245;;19043414;;19043414;;17568776;;17568776;;17568776;;12654245 ZNF148: Method= MI:0493;;MI:0004;;MI:0004 PMID= 11416144;;11416144;;11416144 GNL3: Method= MI:0096;;MI:0096;;MI:0096;;MI:0493;;MI:0006 PMID= 12464630;;12464630;;12464630;;12464630;;12464630 SHISA5: Method= MI:0492 PMID= 12135983 HMGB2: Method= MI:0492 PMID= 11748232 PTTG1: Method= MI:0493;;MI:0004;;MI:0004;;MI:0004 PMID= 12355087;;12355087;;12355087;;12355087 CDK5: Method= MI:0493;;MI:0004;;MI:0004;;MI:0004 PMID= 11483158;;17591690;;17591690;;17591690 YWHAZ: Method= MI:0424;;MI:0493;;MI:0004;;MI:0004;;MI:0424 PMID= 16376338;;9620776;;9620776;;9620776;;16376338 TP53INP1: Method= MI:0096;;MI:0096;;MI:0492;;MI:0096;;MI:0096 PMID= 12851404;;12851404;;11511362;;12851404;;11511362 ZHX1: Method= MI:0018 PMID= 15383276 WRN: Method= MI:0096;;MI:0416;;MI:0004;;MI:0416;;MI:0411;;MI:0411;;MI:0416;;MI:0493;;MI:0004 PMID= 11427532;;11427532;;12080066;;11427532;;15735006;;15735006;;11427532;;11427532;;12080066 ANKRD2: Method= MI:0493;;MI:0004;;MI:0004 PMID= 15136035;;15136035;;15136035 AGBL2: Method= MI:0004 PMID= 20308539 COPS2: Method= MI:0492;;MI:0492 PMID= 11285227;;11285227 TAF10: Method= MI:0004 PMID= 18250150 PLK1: Method= MI:0424;;MI:0006;;MI:0006;;MI:0006;;MI:0424;;MI:0006;;MI:0493;;MI:0006;;MI:0006;;MI:0006;;MI:0006 PMID= 19833129;;16753148;;16753148;;16753148;;19833129;;16753148;;16753148;;16753148;;16753148;;16753148;;16753148 STAT6: Method= MI:0018 PMID= 20121258 SMAD3: Method= MI:0493 PMID= 12732139 PHB: Method= MI:0663;;MI:0663;;MI:0663;;MI:0428;;MI:0493;;MI:0663;;MI:0006;;MI:0006;;MI:0428;;MI:0428 PMID= 16319068;;16319068;;16319068;;14500729;;14500729;;16319068;;20134482;;20134482;;14500729;;14500729 EEF2: Method= MI:0004;;MI:0493 PMID= 12891704;;12891704 TK1: Method= MI:0492;;MI:0398;;MI:0018;;MI:0018;;MI:0018 PMID= 16169070;;16169070;;16169070;;16169070;;16169070 E4F1: Method= MI:0018;;MI:0018;;MI:0493;;MI:0018;;MI:0018 PMID= 10644996;;10644996;;10644996;;10644996;;12446718 PBK: Method= MI:0006;;MI:0018;;MI:0018;;MI:0006;;MI:0018;;MI:0006;;MI:0018;;MI:0006 PMID= 20622899;;17482142;;17482142;;20622899;;17482142;;20622899;;17482142;;20622899 COPS6: Method= MI:0492;;MI:0492 PMID= 11285227;;11285227 RAB4A: Method= MI:0018;;MI:0018;;MI:0018;;MI:0398;;MI:0492 PMID= 16169070;;16169070;;16169070;;16169070;;16169070 ING5: Method= MI:0493;;MI:0004;;MI:0004;;MI:0004;;MI:0004 PMID= 12750254;;12750254;;17954561;;12750254;;17954561 BMP1: Method= MI:0663 PMID= 18624398 TRAPPC11: Method= MI:0004 PMID= 20308539 ING2: Method= MI:0493;;MI:0006;;MI:0004;;MI:0006 PMID= 16782091;;16782091;;16024799;;16782091 GSTM4: Method= MI:0492;;MI:0018;;MI:0018;;MI:0398;;MI:0018 PMID= 16169070;;16169070;;16169070;;16169070;;16169070 USP39: Method= MI:0004;;MI:0007 PMID= 19615732;;19615732 AR: Method= MI:0018;;MI:0018;;MI:0018 PMID= 19481544;;19481544;;11504717 SIN3A: Method= MI:0006;;MI:0004;;MI:0401;;MI:0493;;MI:0004;;MI:0004 PMID= 11359905;;10521394;;10823891;;10823891;;10521394;;10521394 PTK2: Method= MI:0493;;MI:0006;;MI:0006;;MI:0006;;MI:0006;;MI:0006;;MI:0006;;MI:0006;;MI:0401;;MI:0006;;MI:0401;;MI:0006;;MI:0006;;MI:0006;;MI:0006;;MI:0006 PMID= 15855171;;15855171;;15855171;;15855171;;15855171;;15855171;;15855171;;19857493;;18206965;;15855171;;18206965;;15855171;;15855171;;15855171;;19857493;;15855171 STRA13: Method= MI:0493 PMID= 17347673 GPS1: Method= MI:0492;;MI:0492 PMID= 11285227;;11285227 CHD3: Method= MI:0018;;MI:0018 PMID= 10961991;;10961991 YWHAG: Method= MI:0053;;MI:0019;;MI:0019;;MI:0019;;MI:0053;;MI:0053;;MI:0019;;MI:0019;;MI:0019;;MI:0053;;MI:0053;;MI:0493;;MI:0053 PMID= 18812399;;19933256;;19933256;;19933256;;18812399;;18812399;;19933256;;19933256;;19933256;;18812399;;18812399;;15324660;;18812399 CDK1: Method= MI:0493;;MI:0415;;MI:0004;;MI:0045 PMID= 11327730;;10884347;;11327730;;9467949 UBB: Method= MI:0006 PMID= 17936559 SERPINB9: Method= MI:0018;;MI:0398;;MI:0018;;MI:0492;;MI:0018 PMID= 16169070;;16169070;;16169070;;16169070;;16169070 HSPA4: Method= MI:0004 PMID= 18223694 PPM1D: Method= MI:0493 PMID= 17936559 TRIAP1: Method= MI:0493 PMID= 15735003 TADA3: Method= MI:0018;;MI:0004;;MI:0004;;MI:0493 PMID= 11707411;;17452980;;18250150;;11707411 BCL2L1: Method= MI:0493;;MI:0096;;MI:0096;;MI:0493 PMID= 16151013;;16151013;;16151013;;12667443 SPSB1: Method= MI:0004 PMID= 20308539 HDAC3: Method= MI:0493 PMID= 10777477 BCL2: Method= MI:0416;;MI:0416;;MI:0416;;MI:0416;;MI:0416;;MI:0416;;MI:0493;;MI:0045 PMID= 10.1038/emboj.2009.154;;10.1038/emboj.2009.154;;10.1038/emboj.2009.154;;10.1038/emboj.2009.154;;10.1038/emboj.2009.154;;10.1038/emboj.2009.154;;12667443;;9194558 RRM2: Method= MI:0019;;MI:0004;;MI:0493 PMID= 12615712;;12615712;;12615712 PTEN: Method= MI:0004;;MI:0004;;MI:0493 PMID= 12620407;;12620407;;12620407 CEBPB: Method= MI:0006;;MI:0006;;MI:0006;;MI:0006 PMID= 16227626;;16227626;;16227626;;16227626 TP53RK: Method= MI:0492;;MI:0018 PMID= 11546806;;12659830 ZNF24: Method= MI:0018;;MI:0018;;MI:0018;;MI:0492;;MI:0398 PMID= 16169070;;16169070;;16169070;;16169070;;16169070 BANP: Method= MI:0006;;MI:0006;;MI:0493;;MI:0006;;MI:0096;;MI:0096;;MI:0006;;MI:0006;;MI:0006;;MI:0096 PMID= 10.1038/emboj.2009.395;;10.1038/emboj.2009.395;;15701641;;10.1038/emboj.2009.395;;19303885;;19303885;;10.1038/emboj.2009.395;;10.1038/emboj.2009.395;;10.1038/emboj.2009.395;;19303885 PPP1CA: Method= MI:0018;;MI:0018;;MI:0018 PMID= 15231748;;15231748;;15231748 EFEMP2: Method= MI:0493 PMID= 10380882 SP3: Method= MI:0493;;MI:0004 PMID= 15790310;;12665570 KAT5: Method= MI:0004;;MI:0415;;MI:0415;;MI:0493;;MI:0004;;MI:0004;;MI:0004 PMID= 16601686;;18485870;;18485870;;16601686;;18280244;;16601686;;15310756 SMARCC1: Method= MI:0018;;MI:0096;;MI:0006 PMID= 18303029;;11950834;;18303029 CCDC106: Method= MI:0416;;MI:0018;;MI:0416;;MI:0416;;MI:0492;;MI:0416;;MI:0398 PMID= 20159018;;16169070;;20159018;;20159018;;16169070;;20159018;;16169070 PLK3: Method= MI:0415;;MI:0415;;MI:0415;;MI:0415;;MI:0492 PMID= 12242661;;12242661;;11551930;;11551930;;11551930 ATR: Method= MI:0424;;MI:0492;;MI:0686;;MI:0096 PMID= 16293623;;9765199;;10608806;;15159397 SMAD2: Method= MI:0493;;MI:0006;;MI:0006;;MI:0006 PMID= 12732139;;19345189;;19345189;;19345189 SFN: Method= MI:0065;;MI:0004;;MI:0065;;MI:0004;;MI:0065;;MI:0004;;MI:0004;;MI:0065 PMID= 20206173;;11896572;;20206173;;14517281;;20206173;;14517281;;17546054;;20206173 DLEU1: Method= MI:0018;;MI:0492;;MI:0398;;MI:0018 PMID= 16169070;;16169070;;16169070;;16169070 MAGEB18: Method= MI:0096;;MI:0018;;MI:0018;;MI:0018;;MI:0018;;MI:0096;;MI:0096;;MI:0398 PMID= 16713569;;16189514;;16189514;;16189514;;16189514;;16713569;;16713569;;16189514 ARIH2: Method= MI:0018;;MI:0492;;MI:0398;;MI:0018;;MI:0018 PMID= 16169070;;16169070;;16169070;;16169070;;16169070 UBE2N: Method= MI:0096;;MI:0096;;MI:0096 PMID= 17000756;;17000756;;17000756 ZBTB7A: Method= MI:0004;;MI:0004 PMID= 19244234;;19244234 RAD23A: Method= MI:0004 PMID= 15064742 PRKRA: Method= MI:0096;;MI:0096;;MI:0493 PMID= 9010216;;9010216;;9010216 PPA1: Method= MI:0492;;MI:0398;;MI:0018 PMID= 16169070;;16169070;;16169070 NQO1: Method= MI:0493;;MI:0019 PMID= 12529318;;12529318 NPM1: Method= MI:0019;;MI:0019;;MI:0006;;MI:0006;;MI:0006;;MI:0006;;MI:0493;;MI:0107;;MI:0107;;MI:0107;;MI:0107;;MI:0107;;MI:0004;;MI:0107 PMID= 12080348;;12080348;;15144954;;15144954;;15144954;;15144954;;12080348;;16376884;;16376884;;16376884;;16376884;;16376884;;16740634;;16376884 ZBTB2: Method= MI:0004;;MI:0004 PMID= 19380588;;19380588 SETD2: Method= MI:0004;;MI:0004 PMID= 18585004;;18585004 KPNA2: Method= MI:0493 PMID= 10930427 NDN: Method= MI:0492;;MI:0018;;MI:0018 PMID= 10347180;;10347180;;10347180 MTA1: Method= MI:0004;;MI:0492;;MI:0004;;MI:0004;;MI:0004;;MI:0428 PMID= 12920132;;12920132;;17914590;;17914590;;17914590;;20071335 MAGEA2B: Method= MI:0004;;MI:0004 PMID= 16847267;;16847267 SSTR3: Method= MI:0493 PMID= 8961277 CHEK2: Method= MI:0493;;MI:0004;;MI:0424;;MI:0096;;MI:0096;;MI:0424 PMID= 17157788;;12810724;;18833288;;15862297;;15862297;;18833288 WT1: Method= MI:0493;;MI:0004 PMID= 8389468;;8389468 BRF1: Method= MI:0493;;MI:0004 PMID= 8943363;;8943363 MAPK11: Method= MI:0424;;MI:0424;;MI:0424;;MI:0424 PMID= 17254968;;17254968;;17254968;;17254968 BRCC3: Method= MI:0401;;MI:0401;;MI:0401 PMID= 14636569;;14636569;;14636569 SP1: Method= MI:0006;;MI:0006;;MI:0006;;MI:0006;;MI:0006;;MI:0004;;MI:0493;;MI:0004;;MI:0004;;MI:0004;;MI:0004;;MI:0004;;MI:0004;;MI:0006;;MI:0004;;MI:0004 PMID= 15710382;;15710382;;15710382;;15710382;;15710382;;8463313;;9492043;;15674334;;15674334;;18765668;;12665570;;12665570;;12665570;;15710382;;12665570;;16740634 PAGR1: Method= MI:0007;;MI:0007 PMID= 19039327;;19039327 WWOX: Method= MI:0006;;MI:0018;;MI:0006;;MI:0006;;MI:0006;;MI:0493;;MI:0006;;MI:0018;;MI:0006;;MI:0006;;MI:0006;;MI:0493 PMID= 15580310;;11058590;;15580310;;15580310;;15580310;;11058590;;15580310;;11058590;;15580310;;15580310;;15580310;;15580310 PPP1CC: Method= MI:0006;;MI:0493;;MI:0006 PMID= 17274640;;17274640;;17274640 BCR: Method= MI:0398;;MI:0018;;MI:0492 PMID= 16169070;;16169070;;16169070 NAP1L1: Method= MI:0492;;MI:0018;;MI:0018;;MI:0018;;MI:0018 PMID= 14966293;;14966293;;14966293;;14966293;;14966293 TAF9B: Method= MI:0492 PMID= 7761466 USP7: Method= MI:0045;;MI:0045;;MI:0045;;MI:0114;;MI:0007;;MI:0004;;MI:0114;;MI:0114;;MI:0114;;MI:0114;;MI:0004;;MI:0686;;MI:0004;;MI:0004;;MI:0006;;MI:0045;;MI:0045;;MI:0493;;MI:0096;;MI:0006;;MI:0045;;MI:0045;;MI:0004;;MI:0096;;MI:0045;;MI:0096;;MI:0686;;MI:0114 PMID= 11923872;;11923872;;11923872;;16474402;;21170034;;11923872;;16474402;;16474402;;16474402;;16474402;;11923872;;16402859;;11923872;;11923872;;17268548;;11923872;;11923872;;11923872;;16474402;;17268548;;11923872;;11923872;;17380154;;17525743;;11923872;;17525743;;16402859;;16474402 H2AFX: Method= MI:0004;;MI:0004 PMID= 16322227;;16322227 HMGB1: Method= MI:0047;;MI:0096;;MI:0045;;MI:0004;;MI:0492;;MI:0004;;MI:0004;;MI:0004 PMID= 9472015;;11748221;;9472015;;11106654;;9472015;;11106654;;11106654;;11106654 S100A4: Method= MI:0096;;MI:0492;;MI:0071;;MI:0047;;MI:0047;;MI:0071;;MI:0071;;MI:0071 PMID= 11527429;;11527429;;20591429;;19740107;;19740107;;20591429;;20591429;;20591429 SUPT3H: Method= MI:0004 PMID= 18250150 WDR5: Method= MI:0004 PMID= 15960975 TRRAP: Method= MI:0004;;MI:0096;;MI:0096;;MI:0096 PMID= 18250150;;12138177;;12138177;;12138177 XRCC6: Method= MI:0004;;MI:0493;;MI:0006;;MI:0006;;MI:0004 PMID= 15782130;;15782130;;15782130;;15782130;;15782130 HDAC2: Method= MI:0004;;MI:0004;;MI:0004;;MI:0493 PMID= 20190809;;17827154;;14976551;;10777477 DAPK1: Method= MI:0004;;MI:0004 PMID= 17339337;;17339337 S100A2: Method= MI:0071;;MI:0071;;MI:0071;;MI:0071;;MI:0492 PMID= 20591429;;20591429;;20591429;;20591429;;15941720 ZNF420: Method= MI:0004;;MI:0004;;MI:0004;;MI:0004 PMID= 19377469;;19377469;;19377469;;19377469 BLM: Method= MI:0004;;MI:0004;;MI:0004;;MI:0493;;MI:0004;;MI:0004;;MI:0004;;MI:0004;;MI:0004;;MI:0004;;MI:0004;;MI:0004;;MI:0492;;MI:0493 PMID= 12080066;;15364958;;12080066;;11781842;;11399766;;11399766;;11399766;;11781842;;15364958;;11399766;;11781842;;15364958;;15364958;;15064730 HTT: Method= MI:0096;;MI:0096;;MI:0401;;MI:0401;;MI:0401;;MI:0493;;MI:0401 PMID= 10823891;;10823891;;10823891;;10823891;;10823891;;10823891;;10823891 TOPORS: Method= MI:0415;;MI:0428;;MI:0493;;MI:0018;;MI:0096;;MI:0428 PMID= 15247280;;17290218;;10415337;;11842245;;17803295;;17290218 ADH5: Method= MI:0004 PMID= 20308539 S100A6: Method= MI:0071;;MI:0071 PMID= 20591429;;20591429 PRIM1: Method= MI:0493 PMID= 11917009 TFDP1: Method= MI:0492;;MI:0004;;MI:0004 PMID= 8816502;;8816502;;8816502 MAFK: Method= MI:0004 PMID= 19011633 COPS8: Method= MI:0492;;MI:0492 PMID= 11285227;;11285227 MDM4: Method= MI:0004;;MI:0018;;MI:0077;;MI:0415;;MI:0077;;MI:0416;;MI:0096;;MI:0096;;MI:0411;;MI:0077;;MI:0493;;MI:0411;;MI:0415;;MI:0416;;MI:0004;;MI:0077;;MI:0018;;MI:0019;;MI:0416;;MI:0416;;MI:0416;;MI:0416;;MI:0416;;MI:0416;;MI:0411 PMID= 16227609;;15604276;;20515689;;18485870;;20515689;;10.1038/emboj.2009.154;;9226370;;9226370;;17875722;;20515689;;8895579;;17875722;;12393902;;10.1038/emboj.2009.154;;16024788;;20515689;;15604276;;11223036;;10.1038/emboj.2009.154;;10.1038/emboj.2009.154;;10.1038/emboj.2009.154;;10.1038/emboj.2009.154;;10.1038/emboj.2009.154;;10.1038/emboj.2009.154;;17875722 MTOR: Method= MI:0006;;MI:0006 PMID= 19619545;;19619545 PNP: Method= MI:0018;;MI:0492;;MI:0018;;MI:0398;;MI:0018 PMID= 16169070;;16169070;;16169070;;16169070;;16169070 TOP1: Method= MI:0493;;MI:0004;;MI:0018 PMID= 10468612;;10468612;;11805286 DAXX: Method= MI:0007;;MI:0006;;MI:0006;;MI:0006;;MI:0006;;MI:0006;;MI:0006;;MI:0006;;MI:0007;;MI:0007;;MI:0018;;MI:0007;;MI:0416;;MI:0493;;MI:0007;;MI:0007;;MI:0007;;MI:0007;;MI:0018 PMID= 15364927;;16845383;;16845383;;16845383;;16845383;;16845383;;16845383;;16845383;;15364927;;15364927;;14557665;;15364927;;14557665;;12954772;;15364927;;15364927;;15364927;;15364927;;14557665 HSPA1B: Method= MI:0493;;MI:0493 PMID= 7811761;;17184779 HSPA1L: Method= MI:0006;;MI:0006 PMID= 17184779;;17184779 CSNK2B: Method= MI:0493 PMID= 10214938 PCDHA4: Method= MI:0018;;MI:0492;;MI:0018;;MI:0018;;MI:0398 PMID= 16169070;;16169070;;16169070;;16169070;;16169070 MT1A: Method= MI:0006;;MI:0006;;MI:0006;;MI:0006;;MI:0006;;MI:0006 PMID= 16442532;;16442532;;16442532;;16442532;;16442532;;16442532 TMSB4X: Method= MI:0398 PMID= 16169070 CHUK: Method= MI:0493 PMID= 11805286 SNURF: Method= MI:0018;;MI:0018 PMID= 16169070;;16169070 PPP2R2A: Method= MI:0006;;MI:0006 PMID= 17245430;;17245430 ERCC6: Method= MI:0493;;MI:0096;;MI:0004;;MI:0004 PMID= 10882116;;7663514;;10882116;;10882116 DHFR: Method= MI:0492;;MI:0004 PMID= 18451149;;18451149 MIF: Method= MI:0493 PMID= 18815136 PRKDC: Method= MI:0096;;MI:0018;;MI:0492;;MI:0686 PMID= 12756247;;9679063;;10470151;;10608806
Subsetting
Here we query a database for all connections between a set of entities.
require 'rbbt-util'
require 'rbbt/knowledge_base'
require 'rbbt/util/tmpfile'
require 'rbbt/sources/organism'
require 'rbbt/workflow'
Workflow.require_workflow "Genomics"
require 'genomics_kb'
gene = "TP53"
found = Genomics.knowledge_base.identify :pina, gene
p53_interactors = Genomics.knowledge_base.children(:pina, found).target_entity
found = Genomics.knowledge_base.identify :kegg, gene
p53_pathways = Genomics.knowledge_base.children(:kegg, found).target_entity
entities = {"Gene" => p53_interactors, "KeggPathway" => p53_pathways}
puts "Interactors of #{gene} with common kegg pathways"
puts
Genomics.knowledge_base.subset(:kegg, entities).each do |match|
puts match, [match.source_entity.name, match.target_entity.name, match.database, match.info.inspect] * ", "
end- Result
Interactors of TP53 with common kegg pathways ENSG00000050748~hsa04010 MAPK9, MAPK signaling pathway, kegg, {} ENSG00000058335~hsa04010 RASGRF1, MAPK signaling pathway, kegg, {} ENSG00000070831~hsa04010 CDC42, MAPK signaling pathway, kegg, {} ENSG00000089022~hsa04010 MAPKAPK5, MAPK signaling pathway, kegg, {} ENSG00000100030~hsa04010 MAPK1, MAPK signaling pathway, kegg, {} ENSG00000101109~hsa04010 STK4, MAPK signaling pathway, kegg, {} ENSG00000102882~hsa04010 MAPK3, MAPK signaling pathway, kegg, {} ENSG00000104365~hsa04010 IKBKB, MAPK signaling pathway, kegg, {} ENSG00000106211~hsa04010 HSPB1, MAPK signaling pathway, kegg, {} ENSG00000107643~hsa04010 MAPK8, MAPK signaling pathway, kegg, {} ENSG00000109339~hsa04010 MAPK10, MAPK signaling pathway, kegg, {} ENSG00000109971~hsa04010 HSPA8, MAPK signaling pathway, kegg, {} ENSG00000123358~hsa04010 NR4A1, MAPK signaling pathway, kegg, {} ENSG00000154229~hsa04010 PRKCA, MAPK signaling pathway, kegg, {} ENSG00000185386~hsa04010 MAPK11, MAPK signaling pathway, kegg, {} ENSG00000204209~hsa04010 DAXX, MAPK signaling pathway, kegg, {} ENSG00000204388~hsa04010 HSPA1B, MAPK signaling pathway, kegg, {} ENSG00000204390~hsa04010 HSPA1L, MAPK signaling pathway, kegg, {} ENSG00000213341~hsa04010 CHUK, MAPK signaling pathway, kegg, {} ENSG00000005339~hsa04110 CREBBP, Cell cycle, kegg, {} ENSG00000079335~hsa04110 CDC14A, Cell cycle, kegg, {} ENSG00000081377~hsa04110 CDC14B, Cell cycle, kegg, {} ENSG00000082701~hsa04110 GSK3B, Cell cycle, kegg, {} ENSG00000097007~hsa04110 ABL1, Cell cycle, kegg, {} ENSG00000100393~hsa04110 EP300, Cell cycle, kegg, {} ENSG00000101412~hsa04110 E2F1, Cell cycle, kegg, {} ENSG00000108953~hsa04110 YWHAE, Cell cycle, kegg, {} ENSG00000116478~hsa04110 HDAC1, Cell cycle, kegg, {} ENSG00000123080~hsa04110 CDKN2C, Cell cycle, kegg, {} ENSG00000123374~hsa04110 CDK2, Cell cycle, kegg, {} ENSG00000124762~hsa04110 CDKN1A, Cell cycle, kegg, {} ENSG00000134058~hsa04110 CDK7, Cell cycle, kegg, {} ENSG00000134480~hsa04110 CCNH, Cell cycle, kegg, {} ENSG00000135679~hsa04110 MDM2, Cell cycle, kegg, {} ENSG00000145386~hsa04110 CCNA2, Cell cycle, kegg, {} ENSG00000147889~hsa04110 CDKN2A, Cell cycle, kegg, {} ENSG00000149311~hsa04110 ATM, Cell cycle, kegg, {} ENSG00000149554~hsa04110 CHEK1, Cell cycle, kegg, {} ENSG00000158402~hsa04110 CDC25C, Cell cycle, kegg, {} ENSG00000164611~hsa04110 PTTG1, Cell cycle, kegg, {} ENSG00000164924~hsa04110 YWHAZ, Cell cycle, kegg, {} ENSG00000166851~hsa04110 PLK1, Cell cycle, kegg, {} ENSG00000166949~hsa04110 SMAD3, Cell cycle, kegg, {} ENSG00000170027~hsa04110 YWHAG, Cell cycle, kegg, {} ENSG00000170312~hsa04110 CDK1, Cell cycle, kegg, {} ENSG00000175054~hsa04110 ATR, Cell cycle, kegg, {} ENSG00000175387~hsa04110 SMAD2, Cell cycle, kegg, {} ENSG00000175793~hsa04110 SFN, Cell cycle, kegg, {} ENSG00000183765~hsa04110 CHEK2, Cell cycle, kegg, {} ENSG00000196591~hsa04110 HDAC2, Cell cycle, kegg, {} ENSG00000198176~hsa04110 TFDP1, Cell cycle, kegg, {} ENSG00000048392~hsa04115 RRM2B, p53 signaling pathway, kegg, {} ENSG00000078900~hsa04115 TP73, p53 signaling pathway, kegg, {} ENSG00000113328~hsa04115 CCNG1, p53 signaling pathway, kegg, {} ENSG00000123374~hsa04115 CDK2, p53 signaling pathway, kegg, {} ENSG00000124762~hsa04115 CDKN1A, p53 signaling pathway, kegg, {} ENSG00000135679~hsa04115 MDM2, p53 signaling pathway, kegg, {} ENSG00000143207~hsa04115 RFWD2, p53 signaling pathway, kegg, {} ENSG00000147889~hsa04115 CDKN2A, p53 signaling pathway, kegg, {} ENSG00000149311~hsa04115 ATM, p53 signaling pathway, kegg, {} ENSG00000149554~hsa04115 CHEK1, p53 signaling pathway, kegg, {} ENSG00000163743~hsa04115 RCHY1, p53 signaling pathway, kegg, {} ENSG00000164054~hsa04115 SHISA5, p53 signaling pathway, kegg, {} ENSG00000170312~hsa04115 CDK1, p53 signaling pathway, kegg, {} ENSG00000170836~hsa04115 PPM1D, p53 signaling pathway, kegg, {} ENSG00000171848~hsa04115 RRM2, p53 signaling pathway, kegg, {} ENSG00000171862~hsa04115 PTEN, p53 signaling pathway, kegg, {} ENSG00000175054~hsa04115 ATR, p53 signaling pathway, kegg, {} ENSG00000175793~hsa04115 SFN, p53 signaling pathway, kegg, {} ENSG00000183765~hsa04115 CHEK2, p53 signaling pathway, kegg, {} ENSG00000198625~hsa04115 MDM4, p53 signaling pathway, kegg, {} ENSG00000003402~hsa04210 CFLAR, Apoptosis, kegg, {} ENSG00000014216~hsa04210 CAPN1, Apoptosis, kegg, {} ENSG00000100906~hsa04210 NFKBIA, Apoptosis, kegg, {} ENSG00000104365~hsa04210 IKBKB, Apoptosis, kegg, {} ENSG00000149311~hsa04210 ATM, Apoptosis, kegg, {} ENSG00000171552~hsa04210 BCL2L1, Apoptosis, kegg, {} ENSG00000171791~hsa04210 BCL2, Apoptosis, kegg, {} ENSG00000213341~hsa04210 CHUK, Apoptosis, kegg, {} ENSG00000004975~hsa04310 DVL2, Wnt signaling pathway, kegg, {} ENSG00000005339~hsa04310 CREBBP, Wnt signaling pathway, kegg, {} ENSG00000050748~hsa04310 MAPK9, Wnt signaling pathway, kegg, {} ENSG00000078304~hsa04310 PPP2R5C, Wnt signaling pathway, kegg, {} ENSG00000082701~hsa04310 GSK3B, Wnt signaling pathway, kegg, {} ENSG00000100393~hsa04310 EP300, Wnt signaling pathway, kegg, {} ENSG00000100888~hsa04310 CHD8, Wnt signaling pathway, kegg, {} ENSG00000101266~hsa04310 CSNK2A1, Wnt signaling pathway, kegg, {} ENSG00000105568~hsa04310 PPP2R1A, Wnt signaling pathway, kegg, {} ENSG00000107643~hsa04310 MAPK8, Wnt signaling pathway, kegg, {} ENSG00000109339~hsa04310 MAPK10, Wnt signaling pathway, kegg, {} ENSG00000113575~hsa04310 PPP2CA, Wnt signaling pathway, kegg, {} ENSG00000113712~hsa04310 CSNK1A1, Wnt signaling pathway, kegg, {} ENSG00000154229~hsa04310 PRKCA, Wnt signaling pathway, kegg, {} ENSG00000166949~hsa04310 SMAD3, Wnt signaling pathway, kegg, {} ENSG00000175387~hsa04310 SMAD2, Wnt signaling pathway, kegg, {} ENSG00000204435~hsa04310 CSNK2B, Wnt signaling pathway, kegg, {} ENSG00000050748~hsa04722 MAPK9, Neurotrophin signaling pathway, kegg, {} ENSG00000070831~hsa04722 CDC42, Neurotrophin signaling pathway, kegg, {} ENSG00000078900~hsa04722 TP73, Neurotrophin signaling pathway, kegg, {} ENSG00000082701~hsa04722 GSK3B, Neurotrophin signaling pathway, kegg, {} ENSG00000097007~hsa04722 ABL1, Neurotrophin signaling pathway, kegg, {} ENSG00000100030~hsa04722 MAPK1, Neurotrophin signaling pathway, kegg, {} ENSG00000100906~hsa04722 NFKBIA, Neurotrophin signaling pathway, kegg, {} ENSG00000102882~hsa04722 MAPK3, Neurotrophin signaling pathway, kegg, {} ENSG00000104365~hsa04722 IKBKB, Neurotrophin signaling pathway, kegg, {} ENSG00000107643~hsa04722 MAPK8, Neurotrophin signaling pathway, kegg, {} ENSG00000108953~hsa04722 YWHAE, Neurotrophin signaling pathway, kegg, {} ENSG00000109339~hsa04722 MAPK10, Neurotrophin signaling pathway, kegg, {} ENSG00000164924~hsa04722 YWHAZ, Neurotrophin signaling pathway, kegg, {} ENSG00000170027~hsa04722 YWHAG, Neurotrophin signaling pathway, kegg, {} ENSG00000171791~hsa04722 BCL2, Neurotrophin signaling pathway, kegg, {} ENSG00000185386~hsa04722 MAPK11, Neurotrophin signaling pathway, kegg, {} ENSG00000171552~hsa05014 BCL2L1, Amyotrophic lateral sclerosis (ALS), kegg, {} ENSG00000171791~hsa05014 BCL2, Amyotrophic lateral sclerosis (ALS), kegg, {} ENSG00000185386~hsa05014 MAPK11, Amyotrophic lateral sclerosis (ALS), kegg, {} ENSG00000204209~hsa05014 DAXX, Amyotrophic lateral sclerosis (ALS), kegg, {} ENSG00000005339~hsa05016 CREBBP, Huntington's disease, kegg, {} ENSG00000100393~hsa05016 EP300, Huntington's disease, kegg, {} ENSG00000112592~hsa05016 TBP, Huntington's disease, kegg, {} ENSG00000116478~hsa05016 HDAC1, Huntington's disease, kegg, {} ENSG00000118260~hsa05016 CREB1, Huntington's disease, kegg, {} ENSG00000169375~hsa05016 SIN3A, Huntington's disease, kegg, {} ENSG00000185591~hsa05016 SP1, Huntington's disease, kegg, {} ENSG00000196591~hsa05016 HDAC2, Huntington's disease, kegg, {} ENSG00000197386~hsa05016 HTT, Huntington's disease, kegg, {} ENSG00000033800~hsa05160 PIAS1, Hepatitis C, kegg, {} ENSG00000050748~hsa05160 MAPK9, Hepatitis C, kegg, {} ENSG00000055332~hsa05160 EIF2AK2, Hepatitis C, kegg, {} ENSG00000078043~hsa05160 PIAS2, Hepatitis C, kegg, {} ENSG00000082701~hsa05160 GSK3B, Hepatitis C, kegg, {} ENSG00000100030~hsa05160 MAPK1, Hepatitis C, kegg, {} ENSG00000100906~hsa05160 NFKBIA, Hepatitis C, kegg, {} ENSG00000102882~hsa05160 MAPK3, Hepatitis C, kegg, {} ENSG00000104365~hsa05160 IKBKB, Hepatitis C, kegg, {} ENSG00000105229~hsa05160 PIAS4, Hepatitis C, kegg, {} ENSG00000105568~hsa05160 PPP2R1A, Hepatitis C, kegg, {} ENSG00000107643~hsa05160 MAPK8, Hepatitis C, kegg, {} ENSG00000109339~hsa05160 MAPK10, Hepatitis C, kegg, {} ENSG00000113575~hsa05160 PPP2CA, Hepatitis C, kegg, {} ENSG00000124762~hsa05160 CDKN1A, Hepatitis C, kegg, {} ENSG00000131467~hsa05160 PSME3, Hepatitis C, kegg, {} ENSG00000156475~hsa05160 PPP2R2B, Hepatitis C, kegg, {} ENSG00000185386~hsa05160 MAPK11, Hepatitis C, kegg, {} ENSG00000213341~hsa05160 CHUK, Hepatitis C, kegg, {} ENSG00000221914~hsa05160 PPP2R2A, Hepatitis C, kegg, {} ENSG00000004975~hsa05200 DVL2, Pathways in cancer, kegg, {} ENSG00000005339~hsa05200 CREBBP, Pathways in cancer, kegg, {} ENSG00000033800~hsa05200 PIAS1, Pathways in cancer, kegg, {} ENSG00000050748~hsa05200 MAPK9, Pathways in cancer, kegg, {} ENSG00000051180~hsa05200 RAD51, Pathways in cancer, kegg, {} ENSG00000070831~hsa05200 CDC42, Pathways in cancer, kegg, {} ENSG00000073756~hsa05200 PTGS2, Pathways in cancer, kegg, {} ENSG00000078043~hsa05200 PIAS2, Pathways in cancer, kegg, {} ENSG00000080824~hsa05200 HSP90AA1, Pathways in cancer, kegg, {} ENSG00000082701~hsa05200 GSK3B, Pathways in cancer, kegg, {} ENSG00000095002~hsa05200 MSH2, Pathways in cancer, kegg, {} ENSG00000096384~hsa05200 HSP90AB1, Pathways in cancer, kegg, {} ENSG00000097007~hsa05200 ABL1, Pathways in cancer, kegg, {} ENSG00000100030~hsa05200 MAPK1, Pathways in cancer, kegg, {} ENSG00000100393~hsa05200 EP300, Pathways in cancer, kegg, {} ENSG00000100644~hsa05200 HIF1A, Pathways in cancer, kegg, {} ENSG00000100906~hsa05200 NFKBIA, Pathways in cancer, kegg, {} ENSG00000101109~hsa05200 STK4, Pathways in cancer, kegg, {} ENSG00000101412~hsa05200 E2F1, Pathways in cancer, kegg, {} ENSG00000102882~hsa05200 MAPK3, Pathways in cancer, kegg, {} ENSG00000104365~hsa05200 IKBKB, Pathways in cancer, kegg, {} ENSG00000105229~hsa05200 PIAS4, Pathways in cancer, kegg, {} ENSG00000107643~hsa05200 MAPK8, Pathways in cancer, kegg, {} ENSG00000109339~hsa05200 MAPK10, Pathways in cancer, kegg, {} ENSG00000112769~hsa05200 LAMA4, Pathways in cancer, kegg, {} ENSG00000116478~hsa05200 HDAC1, Pathways in cancer, kegg, {} ENSG00000123374~hsa05200 CDK2, Pathways in cancer, kegg, {} ENSG00000124762~hsa05200 CDKN1A, Pathways in cancer, kegg, {} ENSG00000134086~hsa05200 VHL, Pathways in cancer, kegg, {} ENSG00000135679~hsa05200 MDM2, Pathways in cancer, kegg, {} ENSG00000139618~hsa05200 BRCA2, Pathways in cancer, kegg, {} ENSG00000140464~hsa05200 PML, Pathways in cancer, kegg, {} ENSG00000147889~hsa05200 CDKN2A, Pathways in cancer, kegg, {} ENSG00000154229~hsa05200 PRKCA, Pathways in cancer, kegg, {} ENSG00000166949~hsa05200 SMAD3, Pathways in cancer, kegg, {} ENSG00000169083~hsa05200 AR, Pathways in cancer, kegg, {} ENSG00000169398~hsa05200 PTK2, Pathways in cancer, kegg, {} ENSG00000171552~hsa05200 BCL2L1, Pathways in cancer, kegg, {} ENSG00000171791~hsa05200 BCL2, Pathways in cancer, kegg, {} ENSG00000171862~hsa05200 PTEN, Pathways in cancer, kegg, {} ENSG00000175387~hsa05200 SMAD2, Pathways in cancer, kegg, {} ENSG00000186716~hsa05200 BCR, Pathways in cancer, kegg, {} ENSG00000196591~hsa05200 HDAC2, Pathways in cancer, kegg, {} ENSG00000196730~hsa05200 DAPK1, Pathways in cancer, kegg, {} ENSG00000198793~hsa05200 MTOR, Pathways in cancer, kegg, {} ENSG00000213341~hsa05200 CHUK, Pathways in cancer, kegg, {} ENSG00000050748~hsa05210 MAPK9, Colorectal cancer, kegg, {} ENSG00000082701~hsa05210 GSK3B, Colorectal cancer, kegg, {} ENSG00000095002~hsa05210 MSH2, Colorectal cancer, kegg, {} ENSG00000100030~hsa05210 MAPK1, Colorectal cancer, kegg, {} ENSG00000102882~hsa05210 MAPK3, Colorectal cancer, kegg, {} ENSG00000107643~hsa05210 MAPK8, Colorectal cancer, kegg, {} ENSG00000109339~hsa05210 MAPK10, Colorectal cancer, kegg, {} ENSG00000166949~hsa05210 SMAD3, Colorectal cancer, kegg, {} ENSG00000171791~hsa05210 BCL2, Colorectal cancer, kegg, {} ENSG00000175387~hsa05210 SMAD2, Colorectal cancer, kegg, {} ENSG00000050748~hsa05212 MAPK9, Pancreatic cancer, kegg, {} ENSG00000051180~hsa05212 RAD51, Pancreatic cancer, kegg, {} ENSG00000070831~hsa05212 CDC42, Pancreatic cancer, kegg, {} ENSG00000100030~hsa05212 MAPK1, Pancreatic cancer, kegg, {} ENSG00000101412~hsa05212 E2F1, Pancreatic cancer, kegg, {} ENSG00000102882~hsa05212 MAPK3, Pancreatic cancer, kegg, {} ENSG00000104365~hsa05212 IKBKB, Pancreatic cancer, kegg, {} ENSG00000107643~hsa05212 MAPK8, Pancreatic cancer, kegg, {} ENSG00000109339~hsa05212 MAPK10, Pancreatic cancer, kegg, {} ENSG00000139618~hsa05212 BRCA2, Pancreatic cancer, kegg, {} ENSG00000147889~hsa05212 CDKN2A, Pancreatic cancer, kegg, {} ENSG00000166949~hsa05212 SMAD3, Pancreatic cancer, kegg, {} ENSG00000171552~hsa05212 BCL2L1, Pancreatic cancer, kegg, {} ENSG00000175387~hsa05212 SMAD2, Pancreatic cancer, kegg, {} ENSG00000213341~hsa05212 CHUK, Pancreatic cancer, kegg, {} ENSG00000082701~hsa05213 GSK3B, Endometrial cancer, kegg, {} ENSG00000100030~hsa05213 MAPK1, Endometrial cancer, kegg, {} ENSG00000102882~hsa05213 MAPK3, Endometrial cancer, kegg, {} ENSG00000171862~hsa05213 PTEN, Endometrial cancer, kegg, {} ENSG00000100030~hsa05214 MAPK1, Glioma, kegg, {} ENSG00000101412~hsa05214 E2F1, Glioma, kegg, {} ENSG00000102882~hsa05214 MAPK3, Glioma, kegg, {} ENSG00000124762~hsa05214 CDKN1A, Glioma, kegg, {} ENSG00000135679~hsa05214 MDM2, Glioma, kegg, {} ENSG00000147889~hsa05214 CDKN2A, Glioma, kegg, {} ENSG00000154229~hsa05214 PRKCA, Glioma, kegg, {} ENSG00000171862~hsa05214 PTEN, Glioma, kegg, {} ENSG00000198793~hsa05214 MTOR, Glioma, kegg, {} ENSG00000005339~hsa05215 CREBBP, Prostate cancer, kegg, {} ENSG00000080824~hsa05215 HSP90AA1, Prostate cancer, kegg, {} ENSG00000082701~hsa05215 GSK3B, Prostate cancer, kegg, {} ENSG00000096384~hsa05215 HSP90AB1, Prostate cancer, kegg, {} ENSG00000100030~hsa05215 MAPK1, Prostate cancer, kegg, {} ENSG00000100393~hsa05215 EP300, Prostate cancer, kegg, {} ENSG00000100906~hsa05215 NFKBIA, Prostate cancer, kegg, {} ENSG00000101412~hsa05215 E2F1, Prostate cancer, kegg, {} ENSG00000102882~hsa05215 MAPK3, Prostate cancer, kegg, {} ENSG00000104365~hsa05215 IKBKB, Prostate cancer, kegg, {} ENSG00000118260~hsa05215 CREB1, Prostate cancer, kegg, {} ENSG00000123374~hsa05215 CDK2, Prostate cancer, kegg, {} ENSG00000124762~hsa05215 CDKN1A, Prostate cancer, kegg, {} ENSG00000135679~hsa05215 MDM2, Prostate cancer, kegg, {} ENSG00000169083~hsa05215 AR, Prostate cancer, kegg, {} ENSG00000171791~hsa05215 BCL2, Prostate cancer, kegg, {} ENSG00000171862~hsa05215 PTEN, Prostate cancer, kegg, {} ENSG00000198793~hsa05215 MTOR, Prostate cancer, kegg, {} ENSG00000213341~hsa05215 CHUK, Prostate cancer, kegg, {} ENSG00000100030~hsa05216 MAPK1, Thyroid cancer, kegg, {} ENSG00000102882~hsa05216 MAPK3, Thyroid cancer, kegg, {} ENSG00000004975~hsa05217 DVL2, Basal cell carcinoma, kegg, {} ENSG00000082701~hsa05217 GSK3B, Basal cell carcinoma, kegg, {} ENSG00000100030~hsa05218 MAPK1, Melanoma, kegg, {} ENSG00000101412~hsa05218 E2F1, Melanoma, kegg, {} ENSG00000102882~hsa05218 MAPK3, Melanoma, kegg, {} ENSG00000124762~hsa05218 CDKN1A, Melanoma, kegg, {} ENSG00000135679~hsa05218 MDM2, Melanoma, kegg, {} ENSG00000147889~hsa05218 CDKN2A, Melanoma, kegg, {} ENSG00000171862~hsa05218 PTEN, Melanoma, kegg, {} ENSG00000100030~hsa05219 MAPK1, Bladder cancer, kegg, {} ENSG00000101412~hsa05219 E2F1, Bladder cancer, kegg, {} ENSG00000102882~hsa05219 MAPK3, Bladder cancer, kegg, {} ENSG00000124762~hsa05219 CDKN1A, Bladder cancer, kegg, {} ENSG00000135679~hsa05219 MDM2, Bladder cancer, kegg, {} ENSG00000147889~hsa05219 CDKN2A, Bladder cancer, kegg, {} ENSG00000196730~hsa05219 DAPK1, Bladder cancer, kegg, {} ENSG00000097007~hsa05220 ABL1, Chronic myeloid leukemia, kegg, {} ENSG00000100030~hsa05220 MAPK1, Chronic myeloid leukemia, kegg, {} ENSG00000100906~hsa05220 NFKBIA, Chronic myeloid leukemia, kegg, {} ENSG00000101412~hsa05220 E2F1, Chronic myeloid leukemia, kegg, {} ENSG00000102882~hsa05220 MAPK3, Chronic myeloid leukemia, kegg, {} ENSG00000104365~hsa05220 IKBKB, Chronic myeloid leukemia, kegg, {} ENSG00000116478~hsa05220 HDAC1, Chronic myeloid leukemia, kegg, {} ENSG00000124762~hsa05220 CDKN1A, Chronic myeloid leukemia, kegg, {} ENSG00000135679~hsa05220 MDM2, Chronic myeloid leukemia, kegg, {} ENSG00000147889~hsa05220 CDKN2A, Chronic myeloid leukemia, kegg, {} ENSG00000166949~hsa05220 SMAD3, Chronic myeloid leukemia, kegg, {} ENSG00000171552~hsa05220 BCL2L1, Chronic myeloid leukemia, kegg, {} ENSG00000186716~hsa05220 BCR, Chronic myeloid leukemia, kegg, {} ENSG00000196591~hsa05220 HDAC2, Chronic myeloid leukemia, kegg, {} ENSG00000213341~hsa05220 CHUK, Chronic myeloid leukemia, kegg, {} ENSG00000033800~hsa05222 PIAS1, Small cell lung cancer, kegg, {} ENSG00000073756~hsa05222 PTGS2, Small cell lung cancer, kegg, {} ENSG00000078043~hsa05222 PIAS2, Small cell lung cancer, kegg, {} ENSG00000100906~hsa05222 NFKBIA, Small cell lung cancer, kegg, {} ENSG00000101412~hsa05222 E2F1, Small cell lung cancer, kegg, {} ENSG00000104365~hsa05222 IKBKB, Small cell lung cancer, kegg, {} ENSG00000105229~hsa05222 PIAS4, Small cell lung cancer, kegg, {} ENSG00000112769~hsa05222 LAMA4, Small cell lung cancer, kegg, {} ENSG00000123374~hsa05222 CDK2, Small cell lung cancer, kegg, {} ENSG00000169398~hsa05222 PTK2, Small cell lung cancer, kegg, {} ENSG00000171552~hsa05222 BCL2L1, Small cell lung cancer, kegg, {} ENSG00000171791~hsa05222 BCL2, Small cell lung cancer, kegg, {} ENSG00000171862~hsa05222 PTEN, Small cell lung cancer, kegg, {} ENSG00000213341~hsa05222 CHUK, Small cell lung cancer, kegg, {} ENSG00000100030~hsa05223 MAPK1, Non-small cell lung cancer, kegg, {} ENSG00000101109~hsa05223 STK4, Non-small cell lung cancer, kegg, {} ENSG00000101412~hsa05223 E2F1, Non-small cell lung cancer, kegg, {} ENSG00000102882~hsa05223 MAPK3, Non-small cell lung cancer, kegg, {} ENSG00000147889~hsa05223 CDKN2A, Non-small cell lung cancer, kegg, {} ENSG00000154229~hsa05223 PRKCA, Non-small cell lung cancer, kegg, {}