Knowledge Bases in Rbbt
We will go bottom up in this section, starting with association databases and
index the building blocks. Knowledge bases fills a few gaps with the Entity
system to help automatize things.
Association databases
An association database is nothing but a TSV. The key/first-field pair
specifies an association source~target
, the rest of the fields qualify it.
The file can be of any type, but note that :single
and :flat
types will not
have qualifiers; type :double
requires that the qualifiers fields and the
target field match. Usually the key_field
and the first field are of known
Entity
types, but it is not required.
Trivial example
We begin by opening a TSV file as an association file. The
file we are opening is one that lists genes and their associated
GO terms. The file lists genes by their Ensembl Gene ID
.
require 'rbbt-util'
require 'rbbt/association'
require 'rbbt/sources/organism'
assoc = Association.open(Organism.gene_go("Hsa/jan2013"))
gene = "ENSG00000146648"
puts "GO terms of #{gene}"
puts
assoc[gene].zip_fields.collect{|go, cat|
puts [cat, go] * ": "
}
- Result
GO terms of ENSG00000146648 biological_process: GO:0006468 biological_process: GO:0007169 cellular_component: GO:0016021 cellular_component: GO:0016020 molecular_function: GO:0005524 molecular_function: GO:0004672 molecular_function: GO:0004713 molecular_function: GO:0016772 molecular_function: GO:0004714 molecular_function: GO:0004716 biological_process: GO:0008283 biological_process: GO:0007411 biological_process: GO:0043066 biological_process: GO:0000902 biological_process: GO:0008284 biological_process: GO:0007165 biological_process: GO:0048146 biological_process: GO:0000186 biological_process: GO:0016337 biological_process: GO:0048546 biological_process: GO:0006950 biological_process: GO:0007166 biological_process: GO:0030335 biological_process: GO:0045429 biological_process: GO:0001892 biological_process: GO:0043406 biological_process: GO:0050730 biological_process: GO:0051897 biological_process: GO:0046777 biological_process: GO:0001942 biological_process: GO:0007435 biological_process: GO:0045740 biological_process: GO:0001503 biological_process: GO:0050999 biological_process: GO:0050679 biological_process: GO:0051205 biological_process: GO:0007173 biological_process: GO:0000165 biological_process: GO:0021795 biological_process: GO:0042177 biological_process: GO:0007202 biological_process: GO:0060571 biological_process: GO:0045739 biological_process: GO:0042327 biological_process: GO:0042059 biological_process: GO:0031659 biological_process: GO:0035413 biological_process: GO:0043006 biological_process: GO:0070141 cellular_component: GO:0005634 cellular_component: GO:0005737 cellular_component: GO:0005886 cellular_component: GO:0005789 cellular_component: GO:0048471 cellular_component: GO:0000139 cellular_component: GO:0005615 cellular_component: GO:0016323 cellular_component: GO:0031965 cellular_component: GO:0010008 cellular_component: GO:0045121 cellular_component: GO:0005768 cellular_component: GO:0030139 cellular_component: GO:0030122 cellular_component: GO:0070435 molecular_function: GO:0005515 molecular_function: GO:0046982 molecular_function: GO:0003690 molecular_function: GO:0019899 molecular_function: GO:0051015 molecular_function: GO:0004888 molecular_function: GO:0042802 molecular_function: GO:0019903 molecular_function: GO:0004709 molecular_function: GO:0005006 molecular_function: GO:0030235 biological_process: GO:0042127 biological_process: GO:0008544 cellular_component: GO:0005622 molecular_function: GO:0004871 molecular_function: GO:0016301
Translating entities
So far this is no different than doing TSV.open
; in fact, the result in this case
is the same, a TSV file. The Association
module does more than just open the files, it
is aware of entities and their formats. Lets us try a different example, where the
association file is translated to use Associated Gene Name
. For the translation to
work, Rbbt must be aware of the gene entity, which is defined in the Genomics
workflow.
require 'rbbt-util'
require 'rbbt/association'
require 'rbbt/sources/organism'
require 'rbbt/workflow'
Workflow.require_workflow "Genomics"
require 'rbbt/entity/gene'
assoc = Association.open(Organism.gene_go("Hsa/jan2013"),
{:source_format => "Associated Gene Name"})
gene = "EGFR"
puts "Go terms of #{gene}"
puts
assoc[gene].zip_fields.collect{|go, cat|
puts [cat, go] * ": "
}
- Result
Go terms of EGFR biological_process: GO:0006468 biological_process: GO:0007169 cellular_component: GO:0016021 cellular_component: GO:0016020 molecular_function: GO:0005524 molecular_function: GO:0004672 molecular_function: GO:0004713 molecular_function: GO:0016772 molecular_function: GO:0004714 molecular_function: GO:0004716 biological_process: GO:0008283 biological_process: GO:0007411 biological_process: GO:0043066 biological_process: GO:0000902 biological_process: GO:0008284 biological_process: GO:0007165 biological_process: GO:0048146 biological_process: GO:0000186 biological_process: GO:0016337 biological_process: GO:0048546 biological_process: GO:0006950 biological_process: GO:0007166 biological_process: GO:0030335 biological_process: GO:0045429 biological_process: GO:0001892 biological_process: GO:0043406 biological_process: GO:0050730 biological_process: GO:0051897 biological_process: GO:0046777 biological_process: GO:0001942 biological_process: GO:0007435 biological_process: GO:0045740 biological_process: GO:0001503 biological_process: GO:0050999 biological_process: GO:0050679 biological_process: GO:0051205 biological_process: GO:0007173 biological_process: GO:0000165 biological_process: GO:0021795 biological_process: GO:0042177 biological_process: GO:0007202 biological_process: GO:0060571 biological_process: GO:0045739 biological_process: GO:0042327 biological_process: GO:0042059 biological_process: GO:0031659 biological_process: GO:0035413 biological_process: GO:0043006 biological_process: GO:0070141 cellular_component: GO:0005634 cellular_component: GO:0005737 cellular_component: GO:0005886 cellular_component: GO:0005789 cellular_component: GO:0048471 cellular_component: GO:0000139 cellular_component: GO:0005615 cellular_component: GO:0016323 cellular_component: GO:0031965 cellular_component: GO:0010008 cellular_component: GO:0045121 cellular_component: GO:0005768 cellular_component: GO:0030139 cellular_component: GO:0030122 cellular_component: GO:0070435 molecular_function: GO:0005515 molecular_function: GO:0046982 molecular_function: GO:0003690 molecular_function: GO:0019899 molecular_function: GO:0051015 molecular_function: GO:0004888 molecular_function: GO:0042802 molecular_function: GO:0019903 molecular_function: GO:0004709 molecular_function: GO:0005006 molecular_function: GO:0030235 biological_process: GO:0042127 biological_process: GO:0008544 cellular_component: GO:0005622 molecular_function: GO:0004871 molecular_function: GO:0016301
Just a reminder: make the system aware of GO terms to list their descriptions.
GO term entities are defined in their rbbt/sources
file.
require 'rbbt-util'
require 'rbbt/association'
require 'rbbt/sources/organism'
require 'rbbt/workflow'
Workflow.require_workflow "Genomics"
require 'rbbt/entity/gene'
require 'rbbt/sources/go'
assoc = Association.open(Organism.gene_go("Hsa/jan2013"),
{:source_format => "Associated Gene Name"})
gene = "EGFR"
puts "GO terms of #{gene}"
puts
assoc[gene].zip_fields.collect{|values|
# The short hand version used before does not setup the entities.
# Using values_at does
go, cat = values.values_at 0, 1
puts [cat, go.name] * ": "
}
- Result
GO terms of EGFR biological_process: protein phosphorylation biological_process: transmembrane receptor protein tyrosine kinase signaling pathway cellular_component: integral to membrane cellular_component: membrane molecular_function: ATP binding molecular_function: protein kinase activity molecular_function: protein tyrosine kinase activity molecular_function: transferase activity, transferring phosphorus-containing groups molecular_function: transmembrane receptor protein tyrosine kinase activity molecular_function: receptor signaling protein tyrosine kinase activity biological_process: cell proliferation biological_process: axon guidance biological_process: negative regulation of apoptotic process biological_process: cell morphogenesis biological_process: positive regulation of cell proliferation biological_process: signal transduction biological_process: positive regulation of fibroblast proliferation biological_process: activation of MAPKK activity biological_process: cell-cell adhesion biological_process: digestive tract morphogenesis biological_process: response to stress biological_process: cell surface receptor signaling pathway biological_process: positive regulation of cell migration biological_process: positive regulation of nitric oxide biosynthetic process biological_process: embryonic placenta development biological_process: positive regulation of MAP kinase activity biological_process: regulation of peptidyl-tyrosine phosphorylation biological_process: positive regulation of protein kinase B signaling cascade biological_process: protein autophosphorylation biological_process: hair follicle development biological_process: salivary gland morphogenesis biological_process: positive regulation of DNA replication biological_process: ossification biological_process: regulation of nitric-oxide synthase activity biological_process: positive regulation of epithelial cell proliferation biological_process: protein insertion into membrane biological_process: epidermal growth factor receptor signaling pathway biological_process: MAPK cascade biological_process: cerebral cortex cell migration biological_process: negative regulation of protein catabolic process biological_process: activation of phospholipase C activity biological_process: morphogenesis of an epithelial fold biological_process: positive regulation of DNA repair biological_process: positive regulation of phosphorylation biological_process: negative regulation of epidermal growth factor receptor signaling pathway biological_process: positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S biological_process: positive regulation of catenin import into nucleus biological_process: activation of phospholipase A2 activity by calcium-mediated signaling biological_process: response to UV-A cellular_component: nucleus cellular_component: cytoplasm cellular_component: plasma membrane cellular_component: endoplasmic reticulum membrane cellular_component: perinuclear region of cytoplasm cellular_component: Golgi membrane cellular_component: extracellular space cellular_component: basolateral plasma membrane cellular_component: nuclear membrane cellular_component: endosome membrane cellular_component: membrane raft cellular_component: endosome cellular_component: endocytic vesicle cellular_component: AP-2 adaptor complex cellular_component: Shc-EGFR complex molecular_function: protein binding molecular_function: protein heterodimerization activity molecular_function: double-stranded DNA binding molecular_function: enzyme binding molecular_function: actin filament binding molecular_function: transmembrane signaling receptor activity molecular_function: identical protein binding molecular_function: protein phosphatase binding molecular_function: MAP kinase kinase kinase activity molecular_function: epidermal growth factor-activated receptor activity molecular_function: nitric-oxide synthase regulator activity biological_process: regulation of cell proliferation biological_process: epidermis development cellular_component: intracellular molecular_function: signal transducer activity molecular_function: kinase activity
ICGC Example
The same functionalities to specify sources and targets are available when
creating indexes. As our next example shows. Note how we do :persist
the
database, otherwise we could not use Tokyocabinet’s B-tree range search; this
is the default, anyway. Note also the performance benchmark, a million queries
in 10 seconds i.e. 100K queries/second.
require 'rbbt-util'
require 'rbbt/association'
require 'rbbt/sources/organism'
require 'rbbt/workflow'
Workflow.require_workflow "Genomics"
require 'rbbt/entity/gene'
assoc = Association.index('ftp://data.dcc.icgc.org/current/Chronic_Lymphocytic_Leukemia-ISC_MICINN-ES/simple_somatic_mutation.CLLE-ES.tsv.gz',
{ :source => "gene_affected=~Ensembl Gene ID=>Associated Gene Name",
:target => "icgc_donor_id=~Sample",
:fields => ['consequence_type'],
:namespace => 'Hsa/jan2013',
:merge => true, :header_hash=>''}, :persist => true)
puts "Associations: ", assoc.match("SF3B1") * ", "
Misc.benchmark(1_000_000) do
assoc.match("SF3B1")
end
Misc.profile do
Misc.benchmark(1_000) do
assoc.match("SF3B1")
end
end
- Result
Associations: SF3B1~DO6376, SF3B1~DO6392, SF3B1~DO6426, SF3B1~DO6436, SF3B1~DO6468, SF3B1~DO6494, SF3B1~DO6525, SF3B1~DO6898, SF3B1~DO7000 Benchmark for 1000000 repeats 12.530000 0.000000 12.530000 ( 12.532505)
Knowledge Bases
We are ready to put all this together into a knowledge base.
First example
Here we create a knowledge base, on a temporary directory, with namespace
Hsa/jan2013
, and register the Pina protein-protein interaction database. We
need to specify that the target field Interactor UniProt/SwissProt Accession
should be interpreted as UniProt/SwissProt Accession
. We have also specify that
the preferred format for Gene
entities is Associated Gene Name
.
The children
method retrieves the matches from the database, annotated as
AssociationItem
entities. This means we can easily extract the target
,
and we can also extract the target_entity
, which are annotated as their appropriate
entities; which can be viewed in this example when we use the Gene
entity method ensembl
to translate them to Ensembl Gene ID
. Of course, every new layer add some overhead.
Registering a database does not start its processing. Loading the databases,
indices, etc. is done on-demand. Once they are setup the first time, they will
be reused, as usual. Finally, note how the database is registered as
undirected
, which includes the converse of each interaction to the index.
require 'rbbt-util'
require 'rbbt/knowledge_base'
require 'rbbt/util/tmpfile'
require 'rbbt/sources/organism'
require 'rbbt/workflow'
Workflow.require_workflow "Genomics"
require 'rbbt/entity/gene'
require 'rbbt/sources/pina'
TmpFile.with_dir do |dir|
kb = KnowledgeBase.new dir, "Hsa/jan2013"
kb.format["Gene"] = "Associated Gene Name"
kb.register :pina, Pina.protein_protein,
:target => "Interactor UniProt/SwissProt Accession=~UniProt/SwissProt Accession",
:undirected => true
gene = "SF3B1"
puts "Matches: ", kb.children(:pina, gene) * ", "
puts "Targets: ", kb.children(:pina, gene).target * ", "
puts "Ensembl: ", kb.children(:pina, gene).target_entity.ensembl * ", "
puts
Misc.benchmark(10_000) do
kb.indices[:pina].match(gene)
end
Misc.benchmark(10_000) do
kb.children(:pina, gene)
end
Misc.benchmark(10_000) do
kb.children(:pina, gene).target
end
Misc.benchmark(10_000) do
kb.children(:pina, gene).target_entity
end
end
- Result
Matches: SF3B1~APBB1, SF3B1~ARF6, SF3B1~ARPC2, SF3B1~ATG12, SF3B1~BAZ1B, SF3B1~BRF2, SF3B1~CCNE1, SF3B1~CDC5L, SF3B1~CFLAR, SF3B1~DDX42, SF3B1~DYRK1A, SF3B1~GSK3B, SF3B1~H3F3B, SF3B1~HDAC3, SF3B1~IKBKE, SF3B1~MELK, SF3B1~MYC, SF3B1~PHF5A, SF3B1~PPP1R8, SF3B1~PRPF40A, SF3B1~PUF60, SF3B1~RBM17, SF3B1~RNPS1, SF3B1~SAP130, SF3B1~SF3A2, SF3B1~SF3B14, SF3B1~SF3B3, SF3B1~SF3B4, SF3B1~SF3B5, SF3B1~SMAD1, SF3B1~SMAD5, SF3B1~SMAD9, SF3B1~SMNDC1, SF3B1~SNIP1, SF3B1~SNRNP40, SF3B1~SNRPN, SF3B1~TCERG1, SF3B1~TOPORS, SF3B1~WBP4, SF3B1~WWOX, SF3B1~YWHAG, SF3B1~YWHAZ Targets: APBB1, ARF6, ARPC2, ATG12, BAZ1B, BRF2, CCNE1, CDC5L, CFLAR, DDX42, DYRK1A, GSK3B, H3F3B, HDAC3, IKBKE, MELK, MYC, PHF5A, PPP1R8, PRPF40A, PUF60, RBM17, RNPS1, SAP130, SF3A2, SF3B14, SF3B3, SF3B4, SF3B5, SMAD1, SMAD5, SMAD9, SMNDC1, SNIP1, SNRNP40, SNRPN, TCERG1, TOPORS, WBP4, WWOX, YWHAG, YWHAZ Ensembl: ENSG00000166313, ENSG00000165527, ENSG00000163466, ENSG00000145782, ENSG00000009954, ENSG00000104221, ENSG00000105173, ENSG00000096401, ENSG00000003402, ENSG00000198231, ENSG00000157540, ENSG00000082701, ENSG00000132475, ENSG00000171720, ENSG00000143466, ENSG00000165304, ENSG00000136997, ENSG00000100410, ENSG00000117751, ENSG00000196504, ENSG00000179950, ENSG00000134453, ENSG00000205937, ENSG00000136715, ENSG00000104897, ENSG00000115128, ENSG00000189091, ENSG00000143368, ENSG00000169976, ENSG00000170365, ENSG00000113658, ENSG00000120693, ENSG00000119953, ENSG00000163877, ENSG00000060688, ENSG00000128739, ENSG00000113649, ENSG00000197579, ENSG00000120688, ENSG00000186153, ENSG00000170027, ENSG00000164924 Benchmark for 10000 repeats 0.230000 0.010000 0.240000 ( 0.248403) Benchmark for 10000 repeats 0.870000 0.000000 0.870000 ( 0.865072) Benchmark for 10000 repeats 1.470000 0.000000 1.470000 ( 1.472894) Benchmark for 10000 repeats 3.010000 0.000000 3.010000 ( 3.017540)
We can also use the version
method to do this automatically. It will create
a subdirectory in the knowledge base directory with the new namespace, create
a new knowledge base for it and copy the registry
require 'rbbt-util'
require 'rbbt/knowledge_base'
require 'rbbt/util/tmpfile'
require 'rbbt/sources/organism'
require 'rbbt/workflow'
Workflow.require_workflow "Genomics"
require 'genomics_kb'
namespace = "Hsa/may2009"
gene = "TP53"
puts "Organism (namespace) of interactors of #{gene} in the global Genomics KB"
found = Genomics.knowledge_base.identify :pina, gene
puts Genomics.knowledge_base.children(:pina, found).target_entity.organism
kb = Genomics.knowledge_base.version namespace
puts
puts "Organism (namespace) interactors of #{gene} in #{namespace} global KB"
found = kb.identify :pina, gene
puts kb.children(:pina, found).target_entity.organism
- Result
Organism (namespace) of interactors of TP53 in the global Genomics KB Hsa/jan2013 Organism (namespace) interactors of TP53 in Hsa/may2009 global KB Hsa/may2009
Qualifying associations
The following example shows how to access they values that qualify each association. The
values
property of AssociationItem
entities returns a NamedArray
with the qualification
values associated with their corresponding field names.
require 'rbbt-util'
require 'rbbt/knowledge_base'
require 'rbbt/util/tmpfile'
require 'rbbt/sources/organism'
require 'rbbt/workflow'
Workflow.require_workflow "Genomics"
require 'genomics_kb'
gene = "TP53"
puts "Interactors of #{gene}, with qualifiers"
found = Genomics.knowledge_base.identify :pina, gene
Genomics.knowledge_base.children(:pina, found).each do |match|
puts
puts match.target_entity.name << ": "
puts "Method= " << match.values["Method"]
puts "PMID= " << match.values["PMID"]
end
- Result
Interactors of TP53, with qualifiers NFYA: Method= MI:0006;;MI:0006;;MI:0006;;MI:0006;;MI:0006;;MI:0006;;MI:0006;;MI:0006;;MI:0006;;MI:0004;;MI:0006;;MI:0493;;MI:0006;;MI:0006;;MI:0004;;MI:0004 PMID= 16959611;;16959611;;16959611;;16959611;;16959611;;16959611;;16959611;;16959611;;16959611;;15831478;;16959611;;16959611;;16959611;;16959611;;15831478;;15831478 CFLAR: Method= MI:0004;;MI:0004 PMID= 18559494;;18559494 KDM1A: Method= MI:0004;;MI:0004;;MI:0004;;MI:0004;;MI:0004;;MI:0004;;MI:0004 PMID= 17805299;;17805299;;17805299;;17805299;;17805299;;18573881;;18573881 DVL2: Method= MI:0018;;MI:0018;;MI:0018;;MI:0398;;MI:0096;;MI:0018;;MI:0096;;MI:0096 PMID= 16189514;;16189514;;16189514;;16189514;;16713569;;16189514;;16713569;;16713569 CREBBP: Method= MI:0006;;MI:0055;;MI:0493;;MI:0096;;MI:0401;;MI:0096;;MI:0096;;MI:0096;;MI:0006;;MI:0096;;MI:0096;;MI:0096;;MI:0096;;MI:0428;;MI:0006;;MI:0006;;MI:0415;;MI:0096;;MI:0096;;MI:0415;;MI:0004;;MI:0004;;MI:0096;;MI:0415;;MI:0096;;MI:0006 PMID= 9194564;;19166313;;11782467;;10848610;;10823891;;11782467;;14722092;;10196247;;9194564;;11782467;;10196247;;9288775;;9288775;;15632413;;9194564;;9194564;;19805293;;10196247;;10196247;;21390126;;12426395;;16537920;;9194564;;18485870;;9194564;;9194564 MLL5: Method= MI:0004 PMID= 21423215 CCL18: Method= MI:0018;;MI:0018;;MI:0492;;MI:0398;;MI:0018 PMID= 16169070;;16169070;;16169070;;16169070;;16169070 IFRD1: Method= MI:0004;;MI:0004 PMID= 17130840;;17130840 BTK: Method= MI:0492 PMID= 15355990 BRCA1: Method= MI:0493;;MI:0401;;MI:0096;;MI:0401;;MI:0096;;MI:0019;;MI:0096;;MI:0004;;MI:0401;;MI:0004 PMID= 9482880;;14636569;;9582019;;14636569;;9926942;;9482880;;9926942;;9482880;;14636569;;14710355 CAPN1: Method= MI:0493 PMID= 12432277 ZMYND11: Method= MI:0004 PMID= 17721438 MNAT1: Method= MI:0492;;MI:0415;;MI:0415;;MI:0493 PMID= 9372954;;9372954;;9372954;;9840937 VRK2: Method= MI:0415;;MI:0415 PMID= 16704422;;16704422 BAK1: Method= MI:0004;;MI:0004;;MI:0493;;MI:0004 PMID= 15077116;;15077116;;15077116;;15077116 PIAS1: Method= MI:0018;;MI:0018;;MI:0018;;MI:0492;;MI:0096;;MI:0096;;MI:0096;;MI:0096 PMID= 10380882;;11583632;;11583632;;15133049;;15133049;;15133049;;15133049;;11867732 RFC1: Method= MI:0004 PMID= 12509469 MED17: Method= MI:0004;;MI:0492 PMID= 10198638;;10198638 CUL7: Method= MI:0004;;MI:0077;;MI:0004;;MI:0004;;MI:0077;;MI:0077 PMID= 16547496;;17298945;;16547496;;16547496;;17298945;;17298945 EPHA3: Method= MI:0492;;MI:0096 PMID= 15355990;;15355990 HSPA5: Method= MI:0493;;MI:0006;;MI:0006 PMID= 17184779;;17184779;;17184779 RRM2B: Method= MI:0424;;MI:0424;;MI:0004;;MI:0493;;MI:0019 PMID= 19015526;;19015526;;12615712;;12615712;;12615712 MAPK9: Method= MI:0415;;MI:0004;;MI:0493 PMID= 9393873;;12384512;;9393873 RAD51: Method= MI:0493;;MI:0019;;MI:0019;;MI:0096;;MI:0096;;MI:0401;;MI:0004;;MI:0401;;MI:0096;;MI:0401;;MI:0493 PMID= 15064730;;9380510;;9380510;;8617246;;8617246;;14636569;;16983346;;14636569;;9380510;;14636569;;9380510 EIF2AK2: Method= MI:0004;;MI:0004;;MI:0004;;MI:0493;;MI:0004;;MI:0004 PMID= 10348343;;10348343;;10348343;;10348343;;10348343;;10348343 RASGRF1: Method= MI:0006;;MI:0006 PMID= 16753148;;16753148 CCAR1: Method= MI:0004 PMID= 18382127 CA11: Method= MI:0004 PMID= 18382127 HIPK2: Method= MI:0493;;MI:0096;;MI:0096;;MI:0018;;MI:0006;;MI:0096;;MI:0006;;MI:0096;;MI:0493;;MI:0096;;MI:0096 PMID= 16343438;;16212962;;11740489;;11925430;;15896780;;16212962;;15896780;;11740489;;11925430;;11740489;;11740489 YBX1: Method= MI:0493;;MI:0004;;MI:0096;;MI:0096 PMID= 11175333;;15136035;;11175333;;11175333 SMARCD1: Method= MI:0018;;MI:0018 PMID= 18303029;;18303029 ASPM: Method= MI:0004 PMID= 20308539 TRMT11: Method= MI:0004 PMID= 20308539 KLF6: Method= MI:0493 PMID= 15131018 TP53BP1: Method= MI:0114;;MI:0018;;MI:0114;;MI:0096;;MI:0004;;MI:0492;;MI:0018;;MI:0096;;MI:0004;;MI:0018;;MI:0114;;MI:0114;;MI:0004;;MI:0492 PMID= 11877378;;8016121;;12351827;;14978302;;15611139;;12110597;;8016121;;11877378;;15364958;;8016121;;11877378;;12110597;;15364958;;15364958 OTUD5: Method= MI:0007;;MI:0004 PMID= 19615732;;19615732 CDC42: Method= MI:0018;;MI:0492;;MI:0398 PMID= 16169070;;16169070;;16169070 XRCC1: Method= MI:0004;;MI:0096;;MI:0096;;MI:0096;;MI:0096;;MI:0096;;MI:0096 PMID= 15044383;;15044383;;15044383;;15044383;;15044383;;15044383;;15044383 TP63: Method= MI:0006;;MI:0493;;MI:0006;;MI:0006;;MI:0006 PMID= 19345189;;11238924;;19345189;;19345189;;19345189 PTGS2: Method= MI:0493;;MI:0004 PMID= 11687965;;11687965 TSG101: Method= MI:0004;;MI:0493;;MI:0004 PMID= 11172000;;11172000;;11172000 TOP2B: Method= MI:0004;;MI:0493;;MI:0004 PMID= 10666337;;10666337;;10666337 UBE2A: Method= MI:0004;;MI:0416;;MI:0004;;MI:0493 PMID= 12640129;;12640129;;12640129;;12640129 PIAS2: Method= MI:0096;;MI:0018;;MI:0018;;MI:0096;;MI:0663 PMID= 11867732;;19901969;;19901969;;11867732;;18624398 UBE2K: Method= MI:0493 PMID= 10634809 PPP2R5C: Method= MI:0006;;MI:0006 PMID= 17245430;;17245430 ITCH: Method= MI:0004 PMID= 18559494 TP73: Method= MI:0493 PMID= 11238924 CDC14A: Method= MI:0018;;MI:0018;;MI:0493;;MI:0018 PMID= 10644693;;10644693;;10644693;;10644693 PAFAH1B3: Method= MI:0492;;MI:0018;;MI:0398;;MI:0018;;MI:0018 PMID= 16169070;;16169070;;16169070;;16169070;;16169070 HSP90AA1: Method= MI:0493;;MI:0004;;MI:0004;;MI:0004 PMID= 11507088;;11507088;;12427754;;11297531 CDC14B: Method= MI:0018;;MI:0018;;MI:0493 PMID= 10644693;;10644693;;10644693 GSK3B: Method= MI:0027;;MI:0493;;MI:0027;;MI:0027;;MI:0004;;MI:0027;;MI:0004 PMID= 14744935;;12048243;;14744935;;14744935;;12048243;;14744935;;12048243 XPO1: Method= MI:0006;;MI:0006;;MI:0006 PMID= 17268548;;18952844;;17268548 KAT6A: Method= MI:0004;;MI:0004;;MI:0004 PMID= 19001415;;19001415;;19001415 TAF9: Method= MI:0096;;MI:0004 PMID= 7761466;;18250150 HUWE1: Method= MI:0007;;MI:0007;;MI:0492;;MI:0007 PMID= 15989956;;15989956;;15989956;;15989956 TFAP2C: Method= MI:0493;;MI:0428 PMID= 12226108;;12226108 AURKA: Method= MI:0018;;MI:0492;;MI:0018;;MI:0096;;MI:0096;;MI:0096;;MI:0018;;MI:0018;;MI:0018;;MI:0096 PMID= 12198151;;12198151;;12198151;;14702041;;14702041;;14702041;;12198151;;12198151;;12198151;;14702041 MAPKAPK5: Method= MI:0424;;MI:0424;;MI:0424;;MI:0492;;MI:0424 PMID= 17254968;;17254968;;17254968;;17254968;;17254968 APOH: Method= MI:0663 PMID= 18624398 ESR1: Method= MI:0492;;MI:0096 PMID= 10766163;;10766163 EIF2C1: Method= MI:0004 PMID= 20308539 MSH2: Method= MI:0004;;MI:0004;;MI:0493 PMID= 12101417;;12101417;;15064730 HSP90AB1: Method= MI:0493 PMID= 11707401 SIRT1: Method= MI:0493;;MI:0004 PMID= 11672523;;18235502 ABL1: Method= MI:0493;;MI:0096 PMID= 10713716;;10629029 SMARCB1: Method= MI:0096;;MI:0096;;MI:0096;;MI:0493;;MI:0096 PMID= 11950834;;11950834;;11950834;;11950834;;11950834 MAPK1: Method= MI:0493;;MI:0004 PMID= 11409876;;10958792 EP300: Method= MI:0096;;MI:0493;;MI:0415;;MI:0096;;MI:0096;;MI:0096;;MI:0096;;MI:0096;;MI:0096;;MI:0415;;MI:0004;;MI:0006;;MI:0004;;MI:0096;;MI:0006;;MI:0415;;MI:0006;;MI:0004;;MI:0096;;MI:0004;;MI:0071;;MI:0006;;MI:0415;;MI:0004;;MI:0019;;MI:0004;;MI:0006;;MI:0096;;MI:0019;;MI:0006;;MI:0004;;MI:0493;;MI:0006 PMID= 9809062;;16438982;;18485870;;11907332;;15186775;;11782467;;9809062;;9809062;;11782467;;18485870;;15542844;;10518217;;16024799;;11907332;;15542844;;19805293;;16782091;;17452980;;9809062;;16537920;;11070080;;10.1038/emboj.2009.83;;18485870;;16678111;;16611888;;18612383;;10.1038/emboj.2009.83;;15295102;;16611888;;16782091;;17977830;;16782091;;9194564 FKBP3: Method= MI:0096 PMID= 19166840 ERH: Method= MI:0492;;MI:0398;;MI:0018;;MI:0018;;MI:0018 PMID= 16169070;;16169070;;16169070;;16169070;;16169070 HIF1A: Method= MI:0004;;MI:0096;;MI:0004;;MI:0004;;MI:0492;;MI:0096 PMID= 10640274;;12606552;;9537326;;9537326;;12124396;;12124396 VRK1: Method= MI:0004;;MI:0415;;MI:0006;;MI:0493;;MI:0004;;MI:0004 PMID= 15542844;;10951572;;15542844;;10747897;;15542844;;15542844 YY1: Method= MI:0401;;MI:0096;;MI:0096;;MI:0004;;MI:0004;;MI:0004 PMID= 18026119;;15295102;;15295102;;15210108;;15210108;;15210108 APEX1: Method= MI:0493;;MI:0401 PMID= 9119221;;9119221 CHD8: Method= MI:0004 PMID= 19151705 NFKBIA: Method= MI:0004;;MI:0004;;MI:0493 PMID= 11799106;;11799106;;11799106 HNF4A: Method= MI:0096;;MI:0492 PMID= 11818510;;11818510 STK4: Method= MI:0493 PMID= 12384512 CSNK2A1: Method= MI:0493 PMID= 10747897 MYL9: Method= MI:0004 PMID= 20308539 E2F1: Method= MI:0493 PMID= 11739724 PSMD10: Method= MI:0004 PMID= 16023600 POLA1: Method= MI:0004;;MI:0493 PMID= 11917009;;11917009 BMX: Method= MI:0006;;MI:0006;;MI:0006 PMID= 16186805;;16186805;;16186805 USP11: Method= MI:0004;;MI:0007 PMID= 19615732;;19615732 CD40LG: Method= MI:0493 PMID= 12011072 MAPK3: Method= MI:0493;;MI:0004 PMID= 10958792;;10958792 NPRL3: Method= MI:0004 PMID= 20308539 TAF1C: Method= MI:0492;;MI:0096 PMID= 10913176;;10913176 MTHFSD: Method= MI:0004 PMID= 20308539 FAM173A: Method= MI:0492;;MI:0398;;MI:0018 PMID= 16169070;;16169070;;16169070 STUB1: Method= MI:0004 PMID= 18223694 UBE2I: Method= MI:0007;;MI:0007;;MI:0415;;MI:0018;;MI:0018;;MI:0018;;MI:0018;;MI:0663;;MI:0018;;MI:0007;;MI:0007 PMID= 15327968;;15327968;;11853669;;8921390;;10961991;;10380882;;8921390;;18624398;;8921390;;15327968;;15327968 KAT8: Method= MI:0006;;MI:0415;;MI:0004;;MI:0004;;MI:0006 PMID= 16601686;;17189187;;19854137;;15960975;;16601686 IKBKB: Method= MI:0006;;MI:0006 PMID= 19883646;;19883646 PPP1R13L: Method= MI:0065;;MI:0004;;MI:0492 PMID= 18275817;;12524540;;12524540 ERCC2: Method= MI:0096 PMID= 7663514 PIAS4: Method= MI:0018;;MI:0018;;MI:0018 PMID= 15383276;;11388671;;11388671 HNRNPUL1: Method= MI:0493;;MI:0096;;MI:0006;;MI:0006;;MI:0096;;MI:0006;;MI:0096;;MI:0096;;MI:0096;;MI:0006;;MI:0006;;MI:0096;;MI:0096;;MI:0006;;MI:0096;;MI:0006;;MI:0006;;MI:0006;;MI:0006;;MI:0096;;MI:0096;;MI:0096;;MI:0096;;MI:0006;;MI:0096;;MI:0096 PMID= 15907477;;15907477;;15907477;;15907477;;15907477;;15907477;;15907477;;15907477;;15907477;;15907477;;15907477;;15907477;;15907477;;15907477;;15907477;;15907477;;15907477;;15907477;;15907477;;15907477;;15907477;;15907477;;15907477;;15907477;;15907477;;15907477 PPP2R1A: Method= MI:0006;;MI:0006;;MI:0006;;MI:0006 PMID= 17245430;;17245430;;17245430;;17245430 ELL: Method= MI:0493;;MI:0018;;MI:0018;;MI:0018;;MI:0018;;MI:0018 PMID= 10358050;;10358050;;10358050;;10358050;;10358050;;10358050 ETHE1: Method= MI:0004;;MI:0004 PMID= 17353187;;17353187 DNAJB6: Method= MI:0004 PMID= 20308539 HSPB1: Method= MI:0018;;MI:0492;;MI:0398;;MI:0018;;MI:0006;;MI:0006;;MI:0018;;MI:0493 PMID= 16169070;;16169070;;16169070;;16169070;;17184779;;17184779;;16169070;;17184779 TAF6: Method= MI:0096;;MI:0071;;MI:0096;;MI:0096 PMID= 20096117;;7809597;;20096117;;20096117 AIMP2: Method= MI:0004;;MI:0004;;MI:0004;;MI:0004;;MI:0006;;MI:0006 PMID= 18695251;;18695251;;18695251;;18695251;;18695251;;18695251 ZNHIT1: Method= MI:0492 PMID= 17380123 BAG1: Method= MI:0096 PMID= 9582267 MAPK8: Method= MI:0493;;MI:0006;;MI:0096;;MI:0096;;MI:0006;;MI:0415;;MI:0493 PMID= 15580310;;15580310;;15538975;;15538975;;15580310;;9393873;;9732264 GTPBP4: Method= MI:0004 PMID= 20308539 ZMIZ1: Method= MI:0018;;MI:0018;;MI:0018 PMID= 17584785;;17584785;;17584785 TADA2A: Method= MI:0004 PMID= 18250150 KPNB1: Method= MI:0004;;MI:0004;;MI:0493 PMID= 11297531;;11297531;;11297531 SMARCD2: Method= MI:0004 PMID= 20308539 DDX5: Method= MI:0493 PMID= 15660129 PSMD11: Method= MI:0492;;MI:0018;;MI:0018;;MI:0398;;MI:0018 PMID= 16169070;;16169070;;16169070;;16169070;;16169070 KAT2A: Method= MI:0004 PMID= 18250150 YWHAE: Method= MI:0053;;MI:0053;;MI:0053;;MI:0053;;MI:0053;;MI:0053 PMID= 18812399;;18812399;;18812399;;18812399;;18812399;;18812399 DPH1: Method= MI:0004 PMID= 20308539 SULT1E1: Method= MI:0018;;MI:0492;;MI:0398;;MI:0018;;MI:0018 PMID= 16169070;;16169070;;16169070;;16169070;;16169070 MAPK10: Method= MI:0415;;MI:0493 PMID= 9393873;;9393873 HSPA8: Method= MI:0004 PMID= 11297531 HIPK3: Method= MI:0018 PMID= 10961991 GTF2H1: Method= MI:0077;;MI:0077;;MI:0096;;MI:0077;;MI:0077;;MI:0492;;MI:0077;;MI:0077;;MI:0077;;MI:0077;;MI:0077;;MI:0077 PMID= 18354501;;18354501;;7935417;;18354501;;18354501;;7935417;;18354501;;18354501;;18354501;;18354501;;18354501;;18354501 VDR: Method= MI:0416;;MI:0416;;MI:0416;;MI:0416;;MI:0416 PMID= 20227041;;20227041;;20227041;;20227041;;20227041 COPS7A: Method= MI:0492;;MI:0492 PMID= 11285227;;11285227 ING4: Method= MI:0019;;MI:0004;;MI:0493;;MI:0004;;MI:0019;;MI:0004;;MI:0004;;MI:0004;;MI:0004 PMID= 15251430;;12750254;;12750254;;15882981;;15251430;;18775696;;15882981;;17954561;;12750254 ASF1A: Method= MI:0004 PMID= 20308539 PHF1: Method= MI:0004;;MI:0004 PMID= 18385154;;18385154 TBP: Method= MI:0047;;MI:0004;;MI:0047;;MI:0096;;MI:0004;;MI:0096;;MI:0096;;MI:0492 PMID= 7799929;;11313951;;7799929;;1465435;;10359315;;9349482;;9349482;;1465435 CUL9: Method= MI:0018;;MI:0004;;MI:0004;;MI:0004;;MI:0004;;MI:0492;;MI:0004;;MI:0018;;MI:0004 PMID= 18230339;;12526791;;12526791;;12526791;;12526791;;12526791;;12526791;;18230339;;17380154 LAMA4: Method= MI:0018;;MI:0492;;MI:0398 PMID= 16169070;;16169070;;16169070 BRD8: Method= MI:0004 PMID= 20308539 HSPA9: Method= MI:0004;;MI:0004;;MI:0004;;MI:0006;;MI:0004;;MI:0004;;MI:0096;;MI:0096;;MI:0493;;MI:0006;;MI:0004;;MI:0493 PMID= 20153329;;20153329;;20153329;;17184779;;20153329;;20153329;;11900485;;11900485;;11900485;;17184779;;20153329;;17184779 CCNG1: Method= MI:0004;;MI:0493;;MI:0096;;MI:0096 PMID= 12642871;;12556559;;12556559;;12556559 PPP2CA: Method= MI:0493 PMID= 12556559 NR3C1: Method= MI:0493;;MI:0004;;MI:0096;;MI:0096;;MI:0096;;MI:0493 PMID= 11080152;;11080152;;11562347;;11562347;;11562347;;11562347 CSNK1A1: Method= MI:0492 PMID= 9765199 UBE3A: Method= MI:0107;;MI:0107;;MI:0096;;MI:0096;;MI:0493 PMID= 16493710;;16493710;;12620801;;12620801;;9369221 KAT2B: Method= MI:0006;;MI:0006;;MI:0004;;MI:0415;;MI:0004;;MI:0018;;MI:0004 PMID= 16959611;;16959611;;16678111;;12068014;;16537920;;9744860;;17977830 WDR48: Method= MI:0004;;MI:0007 PMID= 19615732;;19615732 NCL: Method= MI:0493;;MI:0004;;MI:0004;;MI:0004 PMID= 12138209;;12138209;;12138209;;12138209 TAF1B: Method= MI:0096;;MI:0492 PMID= 10913176;;10913176 CEBPZ: Method= MI:0493;;MI:0006;;MI:0006;;MI:0004;;MI:0006;;MI:0006;;MI:0004 PMID= 12534345;;12534345;;12534345;;12534345;;12534345;;12534345;;12534345 ARID3A: Method= MI:0493 PMID= 12136662 SUMO1: Method= MI:0492;;MI:0004;;MI:0808;;MI:0096;;MI:0096;;MI:0018;;MI:0004 PMID= 15931224;;12917636;;16732283;;11867732;;18583933;;10961991;;17369817 DHCR24: Method= MI:0493 PMID= 15577914 HDAC1: Method= MI:0006;;MI:0006;;MI:0006;;MI:0004;;MI:0006;;MI:0004;;MI:0004;;MI:0006;;MI:0096;;MI:0096;;MI:0493;;MI:0006;;MI:0096;;MI:0004;;MI:0006;;MI:0004;;MI:0004;;MI:0006;;MI:0004;;MI:0096;;MI:0004;;MI:0004;;MI:0006;;MI:0004 PMID= 16959611;;16959611;;10.1038/emboj.2009.395;;18765668;;10.1038/emboj.2009.395;;14976551;;16697957;;10.1038/emboj.2009.395;;10777477;;10777477;;10777477;;10.1038/emboj.2009.395;;11099047;;16107876;;16959611;;10521394;;17827154;;10.1038/emboj.2009.395;;19011633;;10777477;;11313951;;11313951;;10.1038/emboj.2009.395;;12426395 RBBP5: Method= MI:0004 PMID= 15960975 CR2: Method= MI:0492 PMID= 7753047 STK11: Method= MI:0493;;MI:0004 PMID= 11430832;;11430832 MLL: Method= MI:0004 PMID= 15960975 CREB1: Method= MI:0096;;MI:0096;;MI:0096 PMID= 10848610;;10848610;;10848610 PLAGL1: Method= MI:0492;;MI:0096;;MI:0096 PMID= 11360197;;11360197;;11360197 TTLL5: Method= MI:0004 PMID= 20308539 SUPT7L: Method= MI:0004 PMID= 18250150 KANSL1: Method= MI:0004 PMID= 19854137 EGR1: Method= MI:0027;;MI:0027;;MI:0004;;MI:0004;;MI:0492 PMID= 14744935;;14744935;;11251186;;11251186;;11251186 NFYB: Method= MI:0006;;MI:0006;;MI:0006;;MI:0006;;MI:0006;;MI:0493;;MI:0004 PMID= 16959611;;16959611;;16959611;;16959611;;16959611;;16959611;;15831478 COPS5: Method= MI:0492;;MI:0004;;MI:0492;;MI:0004;;MI:0004;;MI:0004 PMID= 11285227;;16936264;;11285227;;17879958;;17879958;;17879958 RPL5: Method= MI:0493;;MI:0004;;MI:0004 PMID= 7935455;;15308643;;15308643 ZMIZ2: Method= MI:0018 PMID= 17584785 KIAA0087: Method= MI:0018;;MI:0398;;MI:0018 PMID= 16169070;;16169070;;16169070 CDKN2C: Method= MI:0018;;MI:0018;;MI:0398;;MI:0492;;MI:0018 PMID= 16169070;;16169070;;16169070;;16169070;;16169070 NR4A1: Method= MI:0493;;MI:0493;;MI:0007;;MI:0007;;MI:0007;;MI:0007;;MI:0007;;MI:0007;;MI:0004;;MI:0007;;MI:0007;;MI:0007;;MI:0007;;MI:0004;;MI:0007;;MI:0493;;MI:0004;;MI:0007 PMID= 17139261;;17139261;;17139261;;17139261;;17139261;;17139261;;17139261;;17139261;;17139261;;17139261;;17139261;;17139261;;17139261;;17139261;;17139261;;17139261;;17139261;;17139261 CDK2: Method= MI:0493;;MI:0415 PMID= 10884347;;10884347 EIF2C2: Method= MI:0004 PMID= 20308539 CSE1L: Method= MI:0030;;MI:0030;;MI:0030;;MI:0030;;MI:0030 PMID= 17719542;;17719542;;17719542;;17719542;;17719542 SNAI1: Method= MI:0006;;MI:0006;;MI:0006;;MI:0006 PMID= 20385133;;20385133;;20385133;;20385133 NQO2: Method= MI:0004 PMID= 17545619 MAD2L1BP: Method= MI:0018;;MI:0018;;MI:0018;;MI:0398;;MI:0492 PMID= 16169070;;16169070;;16169070;;16169070;;16169070 CDKN1A: Method= MI:0004;;MI:0006;;MI:0006;;MI:0493 PMID= 11896572;;16616141;;16616141;;17139261 PIWIL1: Method= MI:0004 PMID= 20308539 MED1: Method= MI:0006;;MI:0006;;MI:0006;;MI:0096;;MI:0004;;MI:0493;;MI:0006;;MI:0004;;MI:0006;;MI:0006 PMID= 15848166;;15848166;;15848166;;9444950;;9444950;;11118038;;15848166;;11118038;;15848166;;15848166 RPL23: Method= MI:0004;;MI:0004 PMID= 15308643;;15308643 EIF2S2: Method= MI:0492;;MI:0018;;MI:0018;;MI:0398;;MI:0018 PMID= 16169070;;16169070;;16169070;;16169070;;16169070 PRMT1: Method= MI:0096;;MI:0492 PMID= 15186775;;15186775 PIN1: Method= MI:0096;;MI:0096;;MI:0096;;MI:0096;;MI:0096;;MI:0096;;MI:0096;;MI:0096;;MI:0493;;MI:0096;;MI:0096;;MI:0096;;MI:0096 PMID= 12397362;;12397362;;12397362;;12397362;;12397362;;12397362;;12397361;;12397361;;12397362;;12397361;;12397361;;12388558;;12388558 SMARCA4: Method= MI:0004;;MI:0096;;MI:0493;;MI:0096;;MI:0096;;MI:0018;;MI:0006 PMID= 17666433;;11950834;;11950834;;11950834;;11950834;;18303029;;18303029 SNRPN: Method= MI:0492;;MI:0398;;MI:0018 PMID= 16169070;;16169070;;16169070 NEDD8: Method= MI:0004;;MI:0004;;MI:0493;;MI:0004;;MI:0004 PMID= 16620772;;17098746;;16620772;;17546054;;17369817 TEP1: Method= MI:0096;;MI:0493 PMID= 10597287;;10597287 SAT1: Method= MI:0018;;MI:0398;;MI:0018;;MI:0492;;MI:0018 PMID= 16169070;;16169070;;16169070;;16169070;;16169070 DNMT1: Method= MI:0004 PMID= 17991895 HABP4: Method= MI:0018;;MI:0018;;MI:0018;;MI:0018 PMID= 16455055;;16455055;;16455055;;16455055 PSME3: Method= MI:0004;;MI:0004;;MI:0492;;MI:0006;;MI:0004;;MI:0006;;MI:0006;;MI:0006;;MI:0006;;MI:0006;;MI:0006;;MI:0006;;MI:0006;;MI:0006;;MI:0006;;MI:0006;;MI:0006;;MI:0006;;MI:0006;;MI:0006;;MI:0006;;MI:0492;;MI:0006 PMID= 18309296;;18309296;;18309296;;18309296;;18309296;;18309296;;18309296;;18309296;;18309296;;18309296;;18309296;;18309296;;18309296;;18309296;;18309296;;18309296;;18309296;;18309296;;18309296;;18309296;;18309296;;18309296;;18309296 MAP1B: Method= MI:0006;;MI:0006;;MI:0006;;MI:0006;;MI:0006;;MI:0006;;MI:0006;;MI:0006;;MI:0006;;MI:0006;;MI:0006;;MI:0006 PMID= 18656471;;18656471;;18656471;;18656471;;18656471;;18656471;;18656471;;18656471;;18656471;;18656471;;18656471;;18656471 TOP2A: Method= MI:0004;;MI:0493;;MI:0004 PMID= 10666337;;10666337;;10666337 RPA1: Method= MI:0004;;MI:0493;;MI:0018;;MI:0096;;MI:0096;;MI:0411 PMID= 11751427;;11751427;;8663296;;15489903;;15489903;;15735006 GPS2: Method= MI:0493;;MI:0004;;MI:0004 PMID= 11486030;;11486030;;11486030 TOE1: Method= MI:0006;;MI:0006;;MI:0006;;MI:0006;;MI:0006;;MI:0006 PMID= 19508870;;19508870;;19508870;;19508870;;19508870;;19508870 TPT1: Method= MI:0006;;MI:0006;;MI:0006;;MI:0006;;MI:0006;;MI:0006;;MI:0006;;MI:0006;;MI:0006;;MI:0006 PMID= 21081126;;21081126;;21081126;;21081126;;21081126;;21081126;;21081126;;21081126;;21081126;;21081126 BTBD2: Method= MI:0018;;MI:0398;;MI:0018;;MI:0492;;MI:0018;;MI:0398 PMID= 16169070;;16169070;;16169070;;16169070;;16169070;;16169070 PRAM1: Method= MI:0004 PMID= 14976551 MKRN1: Method= MI:0096;;MI:0096;;MI:0096;;MI:0096;;MI:0096;;MI:0096;;MI:0096;;MI:0096;;MI:0096;;MI:0096;;MI:0096;;MI:0096;;MI:0096;;MI:0096;;MI:0096;;MI:0096 PMID= 10.1038/emboj.2009.164;;10.1038/emboj.2009.164;;10.1038/emboj.2009.164;;10.1038/emboj.2009.164;;10.1038/emboj.2009.164;;10.1038/emboj.2009.164;;10.1038/emboj.2009.164;;10.1038/emboj.2009.164;;10.1038/emboj.2009.164;;10.1038/emboj.2009.164;;10.1038/emboj.2009.164;;10.1038/emboj.2009.164;;10.1038/emboj.2009.164;;10.1038/emboj.2009.164;;10.1038/emboj.2009.164;;10.1038/emboj.2009.164 DUSP26: Method= MI:0006;;MI:0006;;MI:0006;;MI:0006;;MI:0006;;MI:0006;;MI:0006;;MI:0006;;MI:0006 PMID= 20562916;;20562916;;20562916;;20562916;;20562916;;20562916;;20562916;;20562916;;20562916 MEN1: Method= MI:0004 PMID= 15960975 NUMB: Method= MI:0004;;MI:0004 PMID= 18172499;;18172499 CDK7: Method= MI:0415;;MI:0047;;MI:0493 PMID= 9372954;;9840937;;9840937 VHL: Method= MI:0004;;MI:0004;;MI:0004 PMID= 16678111;;16678111;;16678111 BHLHE40: Method= MI:0428;;MI:0428;;MI:0428;;MI:0428;;MI:0428;;MI:0428;;MI:0428;;MI:0428;;MI:0428;;MI:0428 PMID= 17347673;;17347673;;17347673;;17347673;;17347673;;17347673;;17347673;;17347673;;17347673;;17347673 CCNH: Method= MI:0047;;MI:0047;;MI:0493 PMID= 9840937;;9840937;;9840937 CABLES1: Method= MI:0492;;MI:0004;;MI:0019 PMID= 14637168;;14637168;;11706030 TEC: Method= MI:0492 PMID= 15355990 MDM2: Method= MI:0007;;MI:0007;;MI:0007;;MI:0007;;MI:0492;;MI:0493;;MI:0493;;MI:0006;;MI:0411;;MI:0006;;MI:0006;;MI:0493;;MI:0493;;MI:0493;;MI:0493;;MI:0493;;MI:0004;;MI:0004;;MI:0004;;MI:0415;;MI:0096;;MI:0415;;MI:0004;;MI:0004;;MI:0004;;MI:0004;;MI:0004;;MI:0006;;MI:0004;;MI:0096;;MI:0411;;MI:0096;;MI:0018;;MI:0428;;MI:0096;;MI:0006;;MI:0006;;MI:0096;;MI:0096;;MI:0004;;MI:0428;;MI:0018;;MI:0401;;MI:0006;;MI:0006;;MI:0096;;MI:0096;;MI:0096;;MI:0006;;MI:0065;;MI:0415;;MI:0416;;MI:0004;;MI:0006;;MI:0096;;MI:0096;;MI:0006;;MI:0004;;MI:0004;;MI:0007;;MI:0007;;MI:0107;;MI:0007;;MI:0007;;MI:0006;;MI:0004;;MI:0415;;MI:0007;;MI:0428;;MI:0071;;MI:0006;;MI:0096;;MI:0018;;MI:0004;;MI:0004;;MI:0415;;MI:0004;;MI:0096;;MI:0096;;MI:0004;;MI:0004;;MI:0007;;MI:0114;;MI:0096;;MI:0004;;MI:0006;;MI:0004;;MI:0114;;MI:0107;;MI:0004;;MI:0071;;MI:0007;;MI:0096;;MI:0096;;MI:0004;;MI:0004;;MI:0096;;MI:0007;;MI:0428;;MI:0428;;MI:0007;;MI:0007;;MI:0428;;MI:0071;;MI:0004;;MI:0090;;MI:0415;;MI:0071;;MI:0004;;MI:0004;;MI:0004;;MI:0007;;MI:0004;;MI:0096;;MI:0007;;MI:0411;;MI:0004;;MI:0007;;MI:0007;;MI:0004;;MI:0096;;MI:0004;;MI:0004;;MI:0004;;MI:0096;;MI:0096;;MI:0004;;MI:0004;;MI:0096;;MI:0004;;MI:0096;;MI:0004;;MI:0428;;MI:0004;;MI:0004;;MI:0018;;MI:0018;;MI:0493;;MI:0415;;MI:0004;;MI:0004;;MI:0018;;MI:0004;;MI:0004;;MI:0004;;MI:0004;;MI:0004;;MI:0006;;MI:0006;;MI:0004;;MI:0114;;MI:0004;;MI:0004;;MI:0004;;MI:0415;;MI:0415;;MI:0096;;MI:0493;;MI:0006;;MI:0006;;MI:0006;;MI:0006;;MI:0006;;MI:0006;;MI:0006;;MI:0492;;MI:0006;;MI:0006;;MI:0006;;MI:0006;;MI:0006 PMID= 19098711;;19098711;;19098711;;19098711;;18632619;;17139261;;18566590;;15144954;;17875722;;12915590;;12915590;;10078201;;11562347;;18382127;;18566590;;17139261;;17470788;;11709713;;12620407;;14671306;;7686617;;18485870;;21454483;;11925449;;12612087;;11925449;;15308643;;15848166;;15542844;;16212962;;17875722;;16212962;;19166840;;12915590;;12915590;;15848166;;15848166;;12915590;;16579792;;16964247;;12915590;;11178989;;7926727;;18309296;;17268548;;16212962;;11384992;;16212962;;18309296;;19255450;;18485870;;20708156;;14612427;;15848166;;17525743;;14702041;;12915590;;12426395;;12426395;;19098711;;19098711;;14704432;;17139261;;17139261;;18309296;;15122315;;18665269;;17159902;;17347673;;20591429;;17268548;;11562347;;19166840;;15308643;;16107876;;10722742;;17098746;;14596917;;10196247;;17936559;;11431470;;17159902;;15154850;;15295102;;14612427;;18309296;;19223463;;15154850;;14704432;;16547496;;20591429;;17139261;;18332869;;18332869;;18172499;;18172499;;16866370;;17139261;;12915590;;12915590;;19098711;;19098711;;17347673;;20591429;;12167711;;15908921;;16857591;;20591429;;15064742;;17908790;;17908790;;19098711;;19085961;;9809062;;19098711;;17875722;;10892746;;19098711;;19098711;;17139261;;19166840;;17139261;;12208736;;19071110;;10766163;;9271120;;17369817;;16624812;;10196247;;15210108;;19303885;;12944468;;11744695;;16023600;;16023600;;9529249;;9529249;;16432196;;18485870;;21454483;;18309296;;10608892;;21454483;;19098711;;18172499;;17591690;;18223694;;19411066;;19411066;;15933712;;8875929;;17380154;;17363365;;11713288;;18485870;;18485870;;19188367;;7935455;;18309296;;18309296;;18309296;;18309296;;18309296;;18309296;;18309296;;18309296;;18309296;;17310983;;17310983;;18952844;;18952844 MPHOSPH6: Method= MI:0018;;MI:0492;;MI:0398;;MI:0018;;MI:0018 PMID= 16169070;;16169070;;16169070;;16169070;;16169070 TAF5L: Method= MI:0004 PMID= 18250150 NMT1: Method= MI:0006;;MI:0006;;MI:0493 PMID= 16530191;;16530191;;16530191 KAT7: Method= MI:0004;;MI:0004;;MI:0004 PMID= 17954561;;17954561;;17954561 WDR33: Method= MI:0018;;MI:0492;;MI:0398 PMID= 16169070;;16169070;;16169070 CDK9: Method= MI:0492 PMID= 16552184 TXN: Method= MI:0096 PMID= 19681600 KLF4: Method= MI:0493 PMID= 10749849 DAB2IP: Method= MI:0004 PMID= 20308539 APTX: Method= MI:0096;;MI:0096;;MI:0004;;MI:0004 PMID= 15044383;;15044383;;15044383;;15044383 RNF38: Method= MI:0004 PMID= 20308539 TFAP2A: Method= MI:0428;;MI:0428;;MI:0428;;MI:0493;;MI:0428 PMID= 12226108;;12226108;;12226108;;12226108;;12226108 MDC1: Method= MI:0004;;MI:0493 PMID= 14519663;;14519663 PRKRIR: Method= MI:0004 PMID= 12384512 FXYD6: Method= MI:0492;;MI:0398;;MI:0018;;MI:0018;;MI:0018 PMID= 16169070;;16169070;;16169070;;16169070;;16169070 FBXO11: Method= MI:0096;;MI:0004;;MI:0493;;MI:0004;;MI:0004;;MI:0096;;MI:0096 PMID= 17098746;;17098746;;17098746;;17098746;;17098746;;17098746;;17098746 LRPPRC: Method= MI:0004 PMID= 20308539 ARL3: Method= MI:0398;;MI:0018;;MI:0018;;MI:0492;;MI:0018 PMID= 16169070;;16169070;;16169070;;16169070;;16169070 BARD1: Method= MI:0401;;MI:0006;;MI:0493;;MI:0401;;MI:0004 PMID= 14636569;;15782130;;15782130;;14636569;;15782130 HECW2: Method= MI:0004 PMID= 12890487 COX17: Method= MI:0018;;MI:0018;;MI:0018;;MI:0492;;MI:0398 PMID= 16169070;;16169070;;16169070;;16169070;;16169070 COPS4: Method= MI:0492;;MI:0492 PMID= 11285227;;11285227 ANXA3: Method= MI:0492;;MI:0398;;MI:0018;;MI:0018;;MI:0018 PMID= 16169070;;16169070;;16169070;;16169070;;16169070 TDG: Method= MI:0018 PMID= 10961991 BRCA2: Method= MI:0004;;MI:0401;;MI:0401;;MI:0401;;MI:0493;;MI:0019 PMID= 9811893;;14636569;;14636569;;14636569;;9811893;;9811893 NCOA2: Method= MI:0676 PMID= 20195357 PML: Method= MI:0006;;MI:0006;;MI:0096;;MI:0006;;MI:0004;;MI:0493;;MI:0004;;MI:0004;;MI:0004;;MI:0004;;MI:0428;;MI:0428;;MI:0096;;MI:0428;;MI:0428 PMID= 12915590;;12915590;;12915590;;12915590;;11025664;;11704853;;11025664;;11080164;;14976551;;11080164;;12915590;;12915590;;12915590;;12915590;;12915590 NOL3: Method= MI:0807 PMID= 18087040 NCOR1: Method= MI:0004 PMID= 19011633 COPS3: Method= MI:0492;;MI:0492 PMID= 11285227;;11285227 CSNK1D: Method= MI:0493 PMID= 9349507 SAE1: Method= MI:0007;;MI:0007 PMID= 15327968;;15327968 RPL11: Method= MI:0004;;MI:0004;;MI:0004;;MI:0004 PMID= 14612427;;15308643;;14612427;;15308643 SERBP1: Method= MI:0018 PMID= 16455055 RFWD2: Method= MI:0007;;MI:0007;;MI:0492;;MI:0004;;MI:0007;;MI:0007;;MI:0007;;MI:0007;;MI:0007;;MI:0007 PMID= 15103385;;15103385;;15103385;;16931761;;15103385;;15103385;;15103385;;15103385;;15103385;;15103385 TAF1A: Method= MI:0096;;MI:0492 PMID= 10913176;;10913176 SMYD2: Method= MI:0492;;MI:0004;;MI:0415;;MI:0415 PMID= 17108971;;18065756;;17108971;;17108971 TP53BP2: Method= MI:0114;;MI:0492;;MI:0065;;MI:0018;;MI:0018;;MI:0018;;MI:0114;;MI:0018;;MI:0018;;MI:0114;;MI:0114;;MI:0018;;MI:0018 PMID= 8875926;;8016121;;18275817;;8668206;;8668206;;8668206;;8875926;;8016121;;8016121;;8875926;;8875926;;8016121;;8016121 S100A8: Method= MI:0018;;MI:0018;;MI:0492;;MI:0398;;MI:0018 PMID= 16169070;;16169070;;16169070;;16169070;;16169070 ACTA1: Method= MI:0492 PMID= 11821948 PARP1: Method= MI:0004;;MI:0004;;MI:0047;;MI:0006;;MI:0096;;MI:0096;;MI:0493;;MI:0096;;MI:0096 PMID= 9312059;;15044383;;9565608;;14627987;;12898523;;12898523;;9565608;;12898523;;12898523 RPS27A: Method= MI:0006;;MI:0006 PMID= 18695251;;18695251 ANK2: Method= MI:0676 PMID= 20195357 CCNA2: Method= MI:0493;;MI:0415 PMID= 10884347;;10884347 SETD7: Method= MI:0415;;MI:0415;;MI:0415;;MI:0493;;MI:0415;;MI:0516;;MI:0415;;MI:0415;;MI:0415;;MI:0415;;MI:0515;;MI:0415;;MI:0415 PMID= 15525938;;15525938;;15525938;;15525938;;15525938;;16415881;;15525938;;15525938;;15525938;;15525938;;16415881;;15525938;;17108971 HDAC8: Method= MI:0114;;MI:0114 PMID= 17721440;;17721440 TAF1: Method= MI:0004 PMID= 10359315 CDKN2A: Method= MI:0018;;MI:0004;;MI:0018;;MI:0018;;MI:0004 PMID= 12446718;;14612427;;9529249;;9529249;;14612427 INPP5E: Method= MI:0004 PMID= 20308539 SERPINH1: Method= MI:0004 PMID= 17977830 ATM: Method= MI:0424;;MI:0045;;MI:0415;;MI:0045;;MI:0492;;MI:0096;;MI:0415;;MI:0096;;MI:0096;;MI:0686;;MI:0415;;MI:0096 PMID= 19015526;;10864201;;17409407;;10864201;;9765199;;9843217;;15064416;;9843217;;15632067;;10608806;;15064416;;15159397 MTA2: Method= MI:0004;;MI:0493;;MI:0096;;MI:0096;;MI:0096 PMID= 12920132;;11099047;;11099047;;11099047;;11099047 CHEK1: Method= MI:0004;;MI:0004;;MI:0019;;MI:0492;;MI:0004;;MI:0096;;MI:0019 PMID= 11896572;;15364958;;16511572;;11896572;;11896572;;12756247;;16511572 CABLES2: Method= MI:0004;;MI:0492 PMID= 14637168;;14637168 PPP4C: Method= MI:0018 PMID= 9837938 CCT5: Method= MI:0398;;MI:0018;;MI:0018;;MI:0492;;MI:0018 PMID= 16169070;;16169070;;16169070;;16169070;;16169070 UBC: Method= MI:0007;;MI:0007;;MI:0007;;MI:0107;;MI:0096;;MI:0006;;MI:0096;;MI:0007;;MI:0006;;MI:0006;;MI:0096;;MI:0007;;MI:0006;;MI:0006;;MI:0007;;MI:0096;;MI:0007;;MI:0006;;MI:0006;;MI:0107;;MI:0006;;MI:0006;;MI:0096;;MI:0007;;MI:0006;;MI:0096;;MI:0096;;MI:0096;;MI:0006;;MI:0006 PMID= 19098711;;17568776;;17568776;;19798103;;17290220;;18566590;;10.1038/emboj.2009.164;;19098711;;18309296;;17268548;;17170702;;17159902;;18309296;;19619542;;17139261;;17170702;;17159902;;19619542;;19619542;;19798103;;17268548;;19619542;;10.1038/emboj.2009.164;;17139261;;18566590;;17290220;;18388957;;18388957;;18566590;;18566590 THRB: Method= MI:0004;;MI:0045;;MI:0493 PMID= 11258898;;8633054;;11258898 TADA1: Method= MI:0004 PMID= 18250150 JMY: Method= MI:0006 PMID= 10518217 NMT2: Method= MI:0006;;MI:0493;;MI:0006 PMID= 16530191;;16530191;;16530191 ING1: Method= MI:0004;;MI:0004;;MI:0492;;MI:0004 PMID= 19085961;;9440695;;12208736;;12208736 PRKCA: Method= MI:0493 PMID= 9935181 UCHL1: Method= MI:0004 PMID= 18666234 ZCCHC10: Method= MI:0492;;MI:0018;;MI:0018;;MI:0398;;MI:0018 PMID= 16169070;;16169070;;16169070;;16169070;;16169070 RNF20: Method= MI:0096;;MI:0096;;MI:0402 PMID= 16337599;;16337599;;19410543 BACH1: Method= MI:0004;;MI:0004;;MI:0004 PMID= 19011633;;19011633;;19011633 PPP2R2B: Method= MI:0493 PMID= 17245430 BRE: Method= MI:0401;;MI:0401;;MI:0401 PMID= 14636569;;14636569;;14636569 CDC25C: Method= MI:0493 PMID= 10853038 DYNC1I1: Method= MI:0006;;MI:0006 PMID= 16616141;;16616141 IGF2BP1: Method= MI:0004 PMID= 20308539 PADI4: Method= MI:0004;;MI:0004;;MI:0004;;MI:0004;;MI:0004;;MI:0004 PMID= 18505818;;20190809;;18505818;;18505818;;18505818;;18505818 S100B: Method= MI:0071;;MI:0004;;MI:0071;;MI:0071;;MI:0004;;MI:0071;;MI:0492 PMID= 20591429;;15178678;;20591429;;20591429;;15178678;;20591429;;11527429 S100A1: Method= MI:0071;;MI:0071;;MI:0071;;MI:0071 PMID= 20591429;;20591429;;20591429;;20591429 THAP8: Method= MI:0492;;MI:0018;;MI:0398;;MI:0018;;MI:0018 PMID= 16169070;;16169070;;16169070;;16169070;;16169070 ZNF385A: Method= MI:0006 PMID= 17719541 STX5: Method= MI:0492;;MI:0018;;MI:0018;;MI:0398;;MI:0018 PMID= 16169070;;16169070;;16169070;;16169070;;16169070 SYVN1: Method= MI:0096;;MI:0493;;MI:0096;;MI:0096;;MI:0096;;MI:0096;;MI:0096;;MI:0096;;MI:0096;;MI:0096;;MI:0096 PMID= 17170702;;17170702;;17170702;;17170702;;17170702;;17170702;;17170702;;17170702;;17170702;;17170702;;17170702 ATF3: Method= MI:0004;;MI:0004;;MI:0492;;MI:0398;;MI:0004;;MI:0004;;MI:0018;;MI:0004 PMID= 11792711;;11792711;;11792711;;16169070;;15933712;;15933712;;16169070;;15933712 MSX1: Method= MI:0493 PMID= 15705871 ERCC3: Method= MI:0492;;MI:0096;;MI:0096 PMID= 7663514;;7663514;;7663514 HIPK1: Method= MI:0018;;MI:0006;;MI:0018;;MI:0006;;MI:0493;;MI:0018 PMID= 12702766;;12702766;;12702766;;12702766;;12702766;;12702766 MNDA: Method= MI:0492 PMID= 16458891 IFI16: Method= MI:0004;;MI:0493 PMID= 11146555;;11146555 RYBP: Method= MI:0007;;MI:0007;;MI:0007;;MI:0007;;MI:0004 PMID= 19098711;;19098711;;19098711;;19098711;;19098711 RCHY1: Method= MI:0007;;MI:0007;;MI:0007;;MI:0007;;MI:0096;;MI:0007;;MI:0007;;MI:0004;;MI:0007;;MI:0004;;MI:0808;;MI:0096;;MI:0007;;MI:0007;;MI:0007;;MI:0493 PMID= 17568776;;17568776;;17568776;;17568776;;19043414;;17568776;;17568776;;12654245;;17568776;;12654245;;19043414;;19043414;;17568776;;17568776;;17568776;;12654245 ZNF148: Method= MI:0493;;MI:0004;;MI:0004 PMID= 11416144;;11416144;;11416144 GNL3: Method= MI:0096;;MI:0096;;MI:0096;;MI:0493;;MI:0006 PMID= 12464630;;12464630;;12464630;;12464630;;12464630 SHISA5: Method= MI:0492 PMID= 12135983 HMGB2: Method= MI:0492 PMID= 11748232 PTTG1: Method= MI:0493;;MI:0004;;MI:0004;;MI:0004 PMID= 12355087;;12355087;;12355087;;12355087 CDK5: Method= MI:0493;;MI:0004;;MI:0004;;MI:0004 PMID= 11483158;;17591690;;17591690;;17591690 YWHAZ: Method= MI:0424;;MI:0493;;MI:0004;;MI:0004;;MI:0424 PMID= 16376338;;9620776;;9620776;;9620776;;16376338 TP53INP1: Method= MI:0096;;MI:0096;;MI:0492;;MI:0096;;MI:0096 PMID= 12851404;;12851404;;11511362;;12851404;;11511362 ZHX1: Method= MI:0018 PMID= 15383276 WRN: Method= MI:0096;;MI:0416;;MI:0004;;MI:0416;;MI:0411;;MI:0411;;MI:0416;;MI:0493;;MI:0004 PMID= 11427532;;11427532;;12080066;;11427532;;15735006;;15735006;;11427532;;11427532;;12080066 ANKRD2: Method= MI:0493;;MI:0004;;MI:0004 PMID= 15136035;;15136035;;15136035 AGBL2: Method= MI:0004 PMID= 20308539 COPS2: Method= MI:0492;;MI:0492 PMID= 11285227;;11285227 TAF10: Method= MI:0004 PMID= 18250150 PLK1: Method= MI:0424;;MI:0006;;MI:0006;;MI:0006;;MI:0424;;MI:0006;;MI:0493;;MI:0006;;MI:0006;;MI:0006;;MI:0006 PMID= 19833129;;16753148;;16753148;;16753148;;19833129;;16753148;;16753148;;16753148;;16753148;;16753148;;16753148 STAT6: Method= MI:0018 PMID= 20121258 SMAD3: Method= MI:0493 PMID= 12732139 PHB: Method= MI:0663;;MI:0663;;MI:0663;;MI:0428;;MI:0493;;MI:0663;;MI:0006;;MI:0006;;MI:0428;;MI:0428 PMID= 16319068;;16319068;;16319068;;14500729;;14500729;;16319068;;20134482;;20134482;;14500729;;14500729 EEF2: Method= MI:0004;;MI:0493 PMID= 12891704;;12891704 TK1: Method= MI:0492;;MI:0398;;MI:0018;;MI:0018;;MI:0018 PMID= 16169070;;16169070;;16169070;;16169070;;16169070 E4F1: Method= MI:0018;;MI:0018;;MI:0493;;MI:0018;;MI:0018 PMID= 10644996;;10644996;;10644996;;10644996;;12446718 PBK: Method= MI:0006;;MI:0018;;MI:0018;;MI:0006;;MI:0018;;MI:0006;;MI:0018;;MI:0006 PMID= 20622899;;17482142;;17482142;;20622899;;17482142;;20622899;;17482142;;20622899 COPS6: Method= MI:0492;;MI:0492 PMID= 11285227;;11285227 RAB4A: Method= MI:0018;;MI:0018;;MI:0018;;MI:0398;;MI:0492 PMID= 16169070;;16169070;;16169070;;16169070;;16169070 ING5: Method= MI:0493;;MI:0004;;MI:0004;;MI:0004;;MI:0004 PMID= 12750254;;12750254;;17954561;;12750254;;17954561 BMP1: Method= MI:0663 PMID= 18624398 TRAPPC11: Method= MI:0004 PMID= 20308539 ING2: Method= MI:0493;;MI:0006;;MI:0004;;MI:0006 PMID= 16782091;;16782091;;16024799;;16782091 GSTM4: Method= MI:0492;;MI:0018;;MI:0018;;MI:0398;;MI:0018 PMID= 16169070;;16169070;;16169070;;16169070;;16169070 USP39: Method= MI:0004;;MI:0007 PMID= 19615732;;19615732 AR: Method= MI:0018;;MI:0018;;MI:0018 PMID= 19481544;;19481544;;11504717 SIN3A: Method= MI:0006;;MI:0004;;MI:0401;;MI:0493;;MI:0004;;MI:0004 PMID= 11359905;;10521394;;10823891;;10823891;;10521394;;10521394 PTK2: Method= MI:0493;;MI:0006;;MI:0006;;MI:0006;;MI:0006;;MI:0006;;MI:0006;;MI:0006;;MI:0401;;MI:0006;;MI:0401;;MI:0006;;MI:0006;;MI:0006;;MI:0006;;MI:0006 PMID= 15855171;;15855171;;15855171;;15855171;;15855171;;15855171;;15855171;;19857493;;18206965;;15855171;;18206965;;15855171;;15855171;;15855171;;19857493;;15855171 STRA13: Method= MI:0493 PMID= 17347673 GPS1: Method= MI:0492;;MI:0492 PMID= 11285227;;11285227 CHD3: Method= MI:0018;;MI:0018 PMID= 10961991;;10961991 YWHAG: Method= MI:0053;;MI:0019;;MI:0019;;MI:0019;;MI:0053;;MI:0053;;MI:0019;;MI:0019;;MI:0019;;MI:0053;;MI:0053;;MI:0493;;MI:0053 PMID= 18812399;;19933256;;19933256;;19933256;;18812399;;18812399;;19933256;;19933256;;19933256;;18812399;;18812399;;15324660;;18812399 CDK1: Method= MI:0493;;MI:0415;;MI:0004;;MI:0045 PMID= 11327730;;10884347;;11327730;;9467949 UBB: Method= MI:0006 PMID= 17936559 SERPINB9: Method= MI:0018;;MI:0398;;MI:0018;;MI:0492;;MI:0018 PMID= 16169070;;16169070;;16169070;;16169070;;16169070 HSPA4: Method= MI:0004 PMID= 18223694 PPM1D: Method= MI:0493 PMID= 17936559 TRIAP1: Method= MI:0493 PMID= 15735003 TADA3: Method= MI:0018;;MI:0004;;MI:0004;;MI:0493 PMID= 11707411;;17452980;;18250150;;11707411 BCL2L1: Method= MI:0493;;MI:0096;;MI:0096;;MI:0493 PMID= 16151013;;16151013;;16151013;;12667443 SPSB1: Method= MI:0004 PMID= 20308539 HDAC3: Method= MI:0493 PMID= 10777477 BCL2: Method= MI:0416;;MI:0416;;MI:0416;;MI:0416;;MI:0416;;MI:0416;;MI:0493;;MI:0045 PMID= 10.1038/emboj.2009.154;;10.1038/emboj.2009.154;;10.1038/emboj.2009.154;;10.1038/emboj.2009.154;;10.1038/emboj.2009.154;;10.1038/emboj.2009.154;;12667443;;9194558 RRM2: Method= MI:0019;;MI:0004;;MI:0493 PMID= 12615712;;12615712;;12615712 PTEN: Method= MI:0004;;MI:0004;;MI:0493 PMID= 12620407;;12620407;;12620407 CEBPB: Method= MI:0006;;MI:0006;;MI:0006;;MI:0006 PMID= 16227626;;16227626;;16227626;;16227626 TP53RK: Method= MI:0492;;MI:0018 PMID= 11546806;;12659830 ZNF24: Method= MI:0018;;MI:0018;;MI:0018;;MI:0492;;MI:0398 PMID= 16169070;;16169070;;16169070;;16169070;;16169070 BANP: Method= MI:0006;;MI:0006;;MI:0493;;MI:0006;;MI:0096;;MI:0096;;MI:0006;;MI:0006;;MI:0006;;MI:0096 PMID= 10.1038/emboj.2009.395;;10.1038/emboj.2009.395;;15701641;;10.1038/emboj.2009.395;;19303885;;19303885;;10.1038/emboj.2009.395;;10.1038/emboj.2009.395;;10.1038/emboj.2009.395;;19303885 PPP1CA: Method= MI:0018;;MI:0018;;MI:0018 PMID= 15231748;;15231748;;15231748 EFEMP2: Method= MI:0493 PMID= 10380882 SP3: Method= MI:0493;;MI:0004 PMID= 15790310;;12665570 KAT5: Method= MI:0004;;MI:0415;;MI:0415;;MI:0493;;MI:0004;;MI:0004;;MI:0004 PMID= 16601686;;18485870;;18485870;;16601686;;18280244;;16601686;;15310756 SMARCC1: Method= MI:0018;;MI:0096;;MI:0006 PMID= 18303029;;11950834;;18303029 CCDC106: Method= MI:0416;;MI:0018;;MI:0416;;MI:0416;;MI:0492;;MI:0416;;MI:0398 PMID= 20159018;;16169070;;20159018;;20159018;;16169070;;20159018;;16169070 PLK3: Method= MI:0415;;MI:0415;;MI:0415;;MI:0415;;MI:0492 PMID= 12242661;;12242661;;11551930;;11551930;;11551930 ATR: Method= MI:0424;;MI:0492;;MI:0686;;MI:0096 PMID= 16293623;;9765199;;10608806;;15159397 SMAD2: Method= MI:0493;;MI:0006;;MI:0006;;MI:0006 PMID= 12732139;;19345189;;19345189;;19345189 SFN: Method= MI:0065;;MI:0004;;MI:0065;;MI:0004;;MI:0065;;MI:0004;;MI:0004;;MI:0065 PMID= 20206173;;11896572;;20206173;;14517281;;20206173;;14517281;;17546054;;20206173 DLEU1: Method= MI:0018;;MI:0492;;MI:0398;;MI:0018 PMID= 16169070;;16169070;;16169070;;16169070 MAGEB18: Method= MI:0096;;MI:0018;;MI:0018;;MI:0018;;MI:0018;;MI:0096;;MI:0096;;MI:0398 PMID= 16713569;;16189514;;16189514;;16189514;;16189514;;16713569;;16713569;;16189514 ARIH2: Method= MI:0018;;MI:0492;;MI:0398;;MI:0018;;MI:0018 PMID= 16169070;;16169070;;16169070;;16169070;;16169070 UBE2N: Method= MI:0096;;MI:0096;;MI:0096 PMID= 17000756;;17000756;;17000756 ZBTB7A: Method= MI:0004;;MI:0004 PMID= 19244234;;19244234 RAD23A: Method= MI:0004 PMID= 15064742 PRKRA: Method= MI:0096;;MI:0096;;MI:0493 PMID= 9010216;;9010216;;9010216 PPA1: Method= MI:0492;;MI:0398;;MI:0018 PMID= 16169070;;16169070;;16169070 NQO1: Method= MI:0493;;MI:0019 PMID= 12529318;;12529318 NPM1: Method= MI:0019;;MI:0019;;MI:0006;;MI:0006;;MI:0006;;MI:0006;;MI:0493;;MI:0107;;MI:0107;;MI:0107;;MI:0107;;MI:0107;;MI:0004;;MI:0107 PMID= 12080348;;12080348;;15144954;;15144954;;15144954;;15144954;;12080348;;16376884;;16376884;;16376884;;16376884;;16376884;;16740634;;16376884 ZBTB2: Method= MI:0004;;MI:0004 PMID= 19380588;;19380588 SETD2: Method= MI:0004;;MI:0004 PMID= 18585004;;18585004 KPNA2: Method= MI:0493 PMID= 10930427 NDN: Method= MI:0492;;MI:0018;;MI:0018 PMID= 10347180;;10347180;;10347180 MTA1: Method= MI:0004;;MI:0492;;MI:0004;;MI:0004;;MI:0004;;MI:0428 PMID= 12920132;;12920132;;17914590;;17914590;;17914590;;20071335 MAGEA2B: Method= MI:0004;;MI:0004 PMID= 16847267;;16847267 SSTR3: Method= MI:0493 PMID= 8961277 CHEK2: Method= MI:0493;;MI:0004;;MI:0424;;MI:0096;;MI:0096;;MI:0424 PMID= 17157788;;12810724;;18833288;;15862297;;15862297;;18833288 WT1: Method= MI:0493;;MI:0004 PMID= 8389468;;8389468 BRF1: Method= MI:0493;;MI:0004 PMID= 8943363;;8943363 MAPK11: Method= MI:0424;;MI:0424;;MI:0424;;MI:0424 PMID= 17254968;;17254968;;17254968;;17254968 BRCC3: Method= MI:0401;;MI:0401;;MI:0401 PMID= 14636569;;14636569;;14636569 SP1: Method= MI:0006;;MI:0006;;MI:0006;;MI:0006;;MI:0006;;MI:0004;;MI:0493;;MI:0004;;MI:0004;;MI:0004;;MI:0004;;MI:0004;;MI:0004;;MI:0006;;MI:0004;;MI:0004 PMID= 15710382;;15710382;;15710382;;15710382;;15710382;;8463313;;9492043;;15674334;;15674334;;18765668;;12665570;;12665570;;12665570;;15710382;;12665570;;16740634 PAGR1: Method= MI:0007;;MI:0007 PMID= 19039327;;19039327 WWOX: Method= MI:0006;;MI:0018;;MI:0006;;MI:0006;;MI:0006;;MI:0493;;MI:0006;;MI:0018;;MI:0006;;MI:0006;;MI:0006;;MI:0493 PMID= 15580310;;11058590;;15580310;;15580310;;15580310;;11058590;;15580310;;11058590;;15580310;;15580310;;15580310;;15580310 PPP1CC: Method= MI:0006;;MI:0493;;MI:0006 PMID= 17274640;;17274640;;17274640 BCR: Method= MI:0398;;MI:0018;;MI:0492 PMID= 16169070;;16169070;;16169070 NAP1L1: Method= MI:0492;;MI:0018;;MI:0018;;MI:0018;;MI:0018 PMID= 14966293;;14966293;;14966293;;14966293;;14966293 TAF9B: Method= MI:0492 PMID= 7761466 USP7: Method= MI:0045;;MI:0045;;MI:0045;;MI:0114;;MI:0007;;MI:0004;;MI:0114;;MI:0114;;MI:0114;;MI:0114;;MI:0004;;MI:0686;;MI:0004;;MI:0004;;MI:0006;;MI:0045;;MI:0045;;MI:0493;;MI:0096;;MI:0006;;MI:0045;;MI:0045;;MI:0004;;MI:0096;;MI:0045;;MI:0096;;MI:0686;;MI:0114 PMID= 11923872;;11923872;;11923872;;16474402;;21170034;;11923872;;16474402;;16474402;;16474402;;16474402;;11923872;;16402859;;11923872;;11923872;;17268548;;11923872;;11923872;;11923872;;16474402;;17268548;;11923872;;11923872;;17380154;;17525743;;11923872;;17525743;;16402859;;16474402 H2AFX: Method= MI:0004;;MI:0004 PMID= 16322227;;16322227 HMGB1: Method= MI:0047;;MI:0096;;MI:0045;;MI:0004;;MI:0492;;MI:0004;;MI:0004;;MI:0004 PMID= 9472015;;11748221;;9472015;;11106654;;9472015;;11106654;;11106654;;11106654 S100A4: Method= MI:0096;;MI:0492;;MI:0071;;MI:0047;;MI:0047;;MI:0071;;MI:0071;;MI:0071 PMID= 11527429;;11527429;;20591429;;19740107;;19740107;;20591429;;20591429;;20591429 SUPT3H: Method= MI:0004 PMID= 18250150 WDR5: Method= MI:0004 PMID= 15960975 TRRAP: Method= MI:0004;;MI:0096;;MI:0096;;MI:0096 PMID= 18250150;;12138177;;12138177;;12138177 XRCC6: Method= MI:0004;;MI:0493;;MI:0006;;MI:0006;;MI:0004 PMID= 15782130;;15782130;;15782130;;15782130;;15782130 HDAC2: Method= MI:0004;;MI:0004;;MI:0004;;MI:0493 PMID= 20190809;;17827154;;14976551;;10777477 DAPK1: Method= MI:0004;;MI:0004 PMID= 17339337;;17339337 S100A2: Method= MI:0071;;MI:0071;;MI:0071;;MI:0071;;MI:0492 PMID= 20591429;;20591429;;20591429;;20591429;;15941720 ZNF420: Method= MI:0004;;MI:0004;;MI:0004;;MI:0004 PMID= 19377469;;19377469;;19377469;;19377469 BLM: Method= MI:0004;;MI:0004;;MI:0004;;MI:0493;;MI:0004;;MI:0004;;MI:0004;;MI:0004;;MI:0004;;MI:0004;;MI:0004;;MI:0004;;MI:0492;;MI:0493 PMID= 12080066;;15364958;;12080066;;11781842;;11399766;;11399766;;11399766;;11781842;;15364958;;11399766;;11781842;;15364958;;15364958;;15064730 HTT: Method= MI:0096;;MI:0096;;MI:0401;;MI:0401;;MI:0401;;MI:0493;;MI:0401 PMID= 10823891;;10823891;;10823891;;10823891;;10823891;;10823891;;10823891 TOPORS: Method= MI:0415;;MI:0428;;MI:0493;;MI:0018;;MI:0096;;MI:0428 PMID= 15247280;;17290218;;10415337;;11842245;;17803295;;17290218 ADH5: Method= MI:0004 PMID= 20308539 S100A6: Method= MI:0071;;MI:0071 PMID= 20591429;;20591429 PRIM1: Method= MI:0493 PMID= 11917009 TFDP1: Method= MI:0492;;MI:0004;;MI:0004 PMID= 8816502;;8816502;;8816502 MAFK: Method= MI:0004 PMID= 19011633 COPS8: Method= MI:0492;;MI:0492 PMID= 11285227;;11285227 MDM4: Method= MI:0004;;MI:0018;;MI:0077;;MI:0415;;MI:0077;;MI:0416;;MI:0096;;MI:0096;;MI:0411;;MI:0077;;MI:0493;;MI:0411;;MI:0415;;MI:0416;;MI:0004;;MI:0077;;MI:0018;;MI:0019;;MI:0416;;MI:0416;;MI:0416;;MI:0416;;MI:0416;;MI:0416;;MI:0411 PMID= 16227609;;15604276;;20515689;;18485870;;20515689;;10.1038/emboj.2009.154;;9226370;;9226370;;17875722;;20515689;;8895579;;17875722;;12393902;;10.1038/emboj.2009.154;;16024788;;20515689;;15604276;;11223036;;10.1038/emboj.2009.154;;10.1038/emboj.2009.154;;10.1038/emboj.2009.154;;10.1038/emboj.2009.154;;10.1038/emboj.2009.154;;10.1038/emboj.2009.154;;17875722 MTOR: Method= MI:0006;;MI:0006 PMID= 19619545;;19619545 PNP: Method= MI:0018;;MI:0492;;MI:0018;;MI:0398;;MI:0018 PMID= 16169070;;16169070;;16169070;;16169070;;16169070 TOP1: Method= MI:0493;;MI:0004;;MI:0018 PMID= 10468612;;10468612;;11805286 DAXX: Method= MI:0007;;MI:0006;;MI:0006;;MI:0006;;MI:0006;;MI:0006;;MI:0006;;MI:0006;;MI:0007;;MI:0007;;MI:0018;;MI:0007;;MI:0416;;MI:0493;;MI:0007;;MI:0007;;MI:0007;;MI:0007;;MI:0018 PMID= 15364927;;16845383;;16845383;;16845383;;16845383;;16845383;;16845383;;16845383;;15364927;;15364927;;14557665;;15364927;;14557665;;12954772;;15364927;;15364927;;15364927;;15364927;;14557665 HSPA1B: Method= MI:0493;;MI:0493 PMID= 7811761;;17184779 HSPA1L: Method= MI:0006;;MI:0006 PMID= 17184779;;17184779 CSNK2B: Method= MI:0493 PMID= 10214938 PCDHA4: Method= MI:0018;;MI:0492;;MI:0018;;MI:0018;;MI:0398 PMID= 16169070;;16169070;;16169070;;16169070;;16169070 MT1A: Method= MI:0006;;MI:0006;;MI:0006;;MI:0006;;MI:0006;;MI:0006 PMID= 16442532;;16442532;;16442532;;16442532;;16442532;;16442532 TMSB4X: Method= MI:0398 PMID= 16169070 CHUK: Method= MI:0493 PMID= 11805286 SNURF: Method= MI:0018;;MI:0018 PMID= 16169070;;16169070 PPP2R2A: Method= MI:0006;;MI:0006 PMID= 17245430;;17245430 ERCC6: Method= MI:0493;;MI:0096;;MI:0004;;MI:0004 PMID= 10882116;;7663514;;10882116;;10882116 DHFR: Method= MI:0492;;MI:0004 PMID= 18451149;;18451149 MIF: Method= MI:0493 PMID= 18815136 PRKDC: Method= MI:0096;;MI:0018;;MI:0492;;MI:0686 PMID= 12756247;;9679063;;10470151;;10608806
Subsetting
Here we query a database for all connections between a set of entities.
require 'rbbt-util'
require 'rbbt/knowledge_base'
require 'rbbt/util/tmpfile'
require 'rbbt/sources/organism'
require 'rbbt/workflow'
Workflow.require_workflow "Genomics"
require 'genomics_kb'
gene = "TP53"
found = Genomics.knowledge_base.identify :pina, gene
p53_interactors = Genomics.knowledge_base.children(:pina, found).target_entity
found = Genomics.knowledge_base.identify :kegg, gene
p53_pathways = Genomics.knowledge_base.children(:kegg, found).target_entity
entities = {"Gene" => p53_interactors, "KeggPathway" => p53_pathways}
puts "Interactors of #{gene} with common kegg pathways"
puts
Genomics.knowledge_base.subset(:kegg, entities).each do |match|
puts match, [match.source_entity.name, match.target_entity.name, match.database, match.info.inspect] * ", "
end
- Result
Interactors of TP53 with common kegg pathways ENSG00000050748~hsa04010 MAPK9, MAPK signaling pathway, kegg, {} ENSG00000058335~hsa04010 RASGRF1, MAPK signaling pathway, kegg, {} ENSG00000070831~hsa04010 CDC42, MAPK signaling pathway, kegg, {} ENSG00000089022~hsa04010 MAPKAPK5, MAPK signaling pathway, kegg, {} ENSG00000100030~hsa04010 MAPK1, MAPK signaling pathway, kegg, {} ENSG00000101109~hsa04010 STK4, MAPK signaling pathway, kegg, {} ENSG00000102882~hsa04010 MAPK3, MAPK signaling pathway, kegg, {} ENSG00000104365~hsa04010 IKBKB, MAPK signaling pathway, kegg, {} ENSG00000106211~hsa04010 HSPB1, MAPK signaling pathway, kegg, {} ENSG00000107643~hsa04010 MAPK8, MAPK signaling pathway, kegg, {} ENSG00000109339~hsa04010 MAPK10, MAPK signaling pathway, kegg, {} ENSG00000109971~hsa04010 HSPA8, MAPK signaling pathway, kegg, {} ENSG00000123358~hsa04010 NR4A1, MAPK signaling pathway, kegg, {} ENSG00000154229~hsa04010 PRKCA, MAPK signaling pathway, kegg, {} ENSG00000185386~hsa04010 MAPK11, MAPK signaling pathway, kegg, {} ENSG00000204209~hsa04010 DAXX, MAPK signaling pathway, kegg, {} ENSG00000204388~hsa04010 HSPA1B, MAPK signaling pathway, kegg, {} ENSG00000204390~hsa04010 HSPA1L, MAPK signaling pathway, kegg, {} ENSG00000213341~hsa04010 CHUK, MAPK signaling pathway, kegg, {} ENSG00000005339~hsa04110 CREBBP, Cell cycle, kegg, {} ENSG00000079335~hsa04110 CDC14A, Cell cycle, kegg, {} ENSG00000081377~hsa04110 CDC14B, Cell cycle, kegg, {} ENSG00000082701~hsa04110 GSK3B, Cell cycle, kegg, {} ENSG00000097007~hsa04110 ABL1, Cell cycle, kegg, {} ENSG00000100393~hsa04110 EP300, Cell cycle, kegg, {} ENSG00000101412~hsa04110 E2F1, Cell cycle, kegg, {} ENSG00000108953~hsa04110 YWHAE, Cell cycle, kegg, {} ENSG00000116478~hsa04110 HDAC1, Cell cycle, kegg, {} ENSG00000123080~hsa04110 CDKN2C, Cell cycle, kegg, {} ENSG00000123374~hsa04110 CDK2, Cell cycle, kegg, {} ENSG00000124762~hsa04110 CDKN1A, Cell cycle, kegg, {} ENSG00000134058~hsa04110 CDK7, Cell cycle, kegg, {} ENSG00000134480~hsa04110 CCNH, Cell cycle, kegg, {} ENSG00000135679~hsa04110 MDM2, Cell cycle, kegg, {} ENSG00000145386~hsa04110 CCNA2, Cell cycle, kegg, {} ENSG00000147889~hsa04110 CDKN2A, Cell cycle, kegg, {} ENSG00000149311~hsa04110 ATM, Cell cycle, kegg, {} ENSG00000149554~hsa04110 CHEK1, Cell cycle, kegg, {} ENSG00000158402~hsa04110 CDC25C, Cell cycle, kegg, {} ENSG00000164611~hsa04110 PTTG1, Cell cycle, kegg, {} ENSG00000164924~hsa04110 YWHAZ, Cell cycle, kegg, {} ENSG00000166851~hsa04110 PLK1, Cell cycle, kegg, {} ENSG00000166949~hsa04110 SMAD3, Cell cycle, kegg, {} ENSG00000170027~hsa04110 YWHAG, Cell cycle, kegg, {} ENSG00000170312~hsa04110 CDK1, Cell cycle, kegg, {} ENSG00000175054~hsa04110 ATR, Cell cycle, kegg, {} ENSG00000175387~hsa04110 SMAD2, Cell cycle, kegg, {} ENSG00000175793~hsa04110 SFN, Cell cycle, kegg, {} ENSG00000183765~hsa04110 CHEK2, Cell cycle, kegg, {} ENSG00000196591~hsa04110 HDAC2, Cell cycle, kegg, {} ENSG00000198176~hsa04110 TFDP1, Cell cycle, kegg, {} ENSG00000048392~hsa04115 RRM2B, p53 signaling pathway, kegg, {} ENSG00000078900~hsa04115 TP73, p53 signaling pathway, kegg, {} ENSG00000113328~hsa04115 CCNG1, p53 signaling pathway, kegg, {} ENSG00000123374~hsa04115 CDK2, p53 signaling pathway, kegg, {} ENSG00000124762~hsa04115 CDKN1A, p53 signaling pathway, kegg, {} ENSG00000135679~hsa04115 MDM2, p53 signaling pathway, kegg, {} ENSG00000143207~hsa04115 RFWD2, p53 signaling pathway, kegg, {} ENSG00000147889~hsa04115 CDKN2A, p53 signaling pathway, kegg, {} ENSG00000149311~hsa04115 ATM, p53 signaling pathway, kegg, {} ENSG00000149554~hsa04115 CHEK1, p53 signaling pathway, kegg, {} ENSG00000163743~hsa04115 RCHY1, p53 signaling pathway, kegg, {} ENSG00000164054~hsa04115 SHISA5, p53 signaling pathway, kegg, {} ENSG00000170312~hsa04115 CDK1, p53 signaling pathway, kegg, {} ENSG00000170836~hsa04115 PPM1D, p53 signaling pathway, kegg, {} ENSG00000171848~hsa04115 RRM2, p53 signaling pathway, kegg, {} ENSG00000171862~hsa04115 PTEN, p53 signaling pathway, kegg, {} ENSG00000175054~hsa04115 ATR, p53 signaling pathway, kegg, {} ENSG00000175793~hsa04115 SFN, p53 signaling pathway, kegg, {} ENSG00000183765~hsa04115 CHEK2, p53 signaling pathway, kegg, {} ENSG00000198625~hsa04115 MDM4, p53 signaling pathway, kegg, {} ENSG00000003402~hsa04210 CFLAR, Apoptosis, kegg, {} ENSG00000014216~hsa04210 CAPN1, Apoptosis, kegg, {} ENSG00000100906~hsa04210 NFKBIA, Apoptosis, kegg, {} ENSG00000104365~hsa04210 IKBKB, Apoptosis, kegg, {} ENSG00000149311~hsa04210 ATM, Apoptosis, kegg, {} ENSG00000171552~hsa04210 BCL2L1, Apoptosis, kegg, {} ENSG00000171791~hsa04210 BCL2, Apoptosis, kegg, {} ENSG00000213341~hsa04210 CHUK, Apoptosis, kegg, {} ENSG00000004975~hsa04310 DVL2, Wnt signaling pathway, kegg, {} ENSG00000005339~hsa04310 CREBBP, Wnt signaling pathway, kegg, {} ENSG00000050748~hsa04310 MAPK9, Wnt signaling pathway, kegg, {} ENSG00000078304~hsa04310 PPP2R5C, Wnt signaling pathway, kegg, {} ENSG00000082701~hsa04310 GSK3B, Wnt signaling pathway, kegg, {} ENSG00000100393~hsa04310 EP300, Wnt signaling pathway, kegg, {} ENSG00000100888~hsa04310 CHD8, Wnt signaling pathway, kegg, {} ENSG00000101266~hsa04310 CSNK2A1, Wnt signaling pathway, kegg, {} ENSG00000105568~hsa04310 PPP2R1A, Wnt signaling pathway, kegg, {} ENSG00000107643~hsa04310 MAPK8, Wnt signaling pathway, kegg, {} ENSG00000109339~hsa04310 MAPK10, Wnt signaling pathway, kegg, {} ENSG00000113575~hsa04310 PPP2CA, Wnt signaling pathway, kegg, {} ENSG00000113712~hsa04310 CSNK1A1, Wnt signaling pathway, kegg, {} ENSG00000154229~hsa04310 PRKCA, Wnt signaling pathway, kegg, {} ENSG00000166949~hsa04310 SMAD3, Wnt signaling pathway, kegg, {} ENSG00000175387~hsa04310 SMAD2, Wnt signaling pathway, kegg, {} ENSG00000204435~hsa04310 CSNK2B, Wnt signaling pathway, kegg, {} ENSG00000050748~hsa04722 MAPK9, Neurotrophin signaling pathway, kegg, {} ENSG00000070831~hsa04722 CDC42, Neurotrophin signaling pathway, kegg, {} ENSG00000078900~hsa04722 TP73, Neurotrophin signaling pathway, kegg, {} ENSG00000082701~hsa04722 GSK3B, Neurotrophin signaling pathway, kegg, {} ENSG00000097007~hsa04722 ABL1, Neurotrophin signaling pathway, kegg, {} ENSG00000100030~hsa04722 MAPK1, Neurotrophin signaling pathway, kegg, {} ENSG00000100906~hsa04722 NFKBIA, Neurotrophin signaling pathway, kegg, {} ENSG00000102882~hsa04722 MAPK3, Neurotrophin signaling pathway, kegg, {} ENSG00000104365~hsa04722 IKBKB, Neurotrophin signaling pathway, kegg, {} ENSG00000107643~hsa04722 MAPK8, Neurotrophin signaling pathway, kegg, {} ENSG00000108953~hsa04722 YWHAE, Neurotrophin signaling pathway, kegg, {} ENSG00000109339~hsa04722 MAPK10, Neurotrophin signaling pathway, kegg, {} ENSG00000164924~hsa04722 YWHAZ, Neurotrophin signaling pathway, kegg, {} ENSG00000170027~hsa04722 YWHAG, Neurotrophin signaling pathway, kegg, {} ENSG00000171791~hsa04722 BCL2, Neurotrophin signaling pathway, kegg, {} ENSG00000185386~hsa04722 MAPK11, Neurotrophin signaling pathway, kegg, {} ENSG00000171552~hsa05014 BCL2L1, Amyotrophic lateral sclerosis (ALS), kegg, {} ENSG00000171791~hsa05014 BCL2, Amyotrophic lateral sclerosis (ALS), kegg, {} ENSG00000185386~hsa05014 MAPK11, Amyotrophic lateral sclerosis (ALS), kegg, {} ENSG00000204209~hsa05014 DAXX, Amyotrophic lateral sclerosis (ALS), kegg, {} ENSG00000005339~hsa05016 CREBBP, Huntington's disease, kegg, {} ENSG00000100393~hsa05016 EP300, Huntington's disease, kegg, {} ENSG00000112592~hsa05016 TBP, Huntington's disease, kegg, {} ENSG00000116478~hsa05016 HDAC1, Huntington's disease, kegg, {} ENSG00000118260~hsa05016 CREB1, Huntington's disease, kegg, {} ENSG00000169375~hsa05016 SIN3A, Huntington's disease, kegg, {} ENSG00000185591~hsa05016 SP1, Huntington's disease, kegg, {} ENSG00000196591~hsa05016 HDAC2, Huntington's disease, kegg, {} ENSG00000197386~hsa05016 HTT, Huntington's disease, kegg, {} ENSG00000033800~hsa05160 PIAS1, Hepatitis C, kegg, {} ENSG00000050748~hsa05160 MAPK9, Hepatitis C, kegg, {} ENSG00000055332~hsa05160 EIF2AK2, Hepatitis C, kegg, {} ENSG00000078043~hsa05160 PIAS2, Hepatitis C, kegg, {} ENSG00000082701~hsa05160 GSK3B, Hepatitis C, kegg, {} ENSG00000100030~hsa05160 MAPK1, Hepatitis C, kegg, {} ENSG00000100906~hsa05160 NFKBIA, Hepatitis C, kegg, {} ENSG00000102882~hsa05160 MAPK3, Hepatitis C, kegg, {} ENSG00000104365~hsa05160 IKBKB, Hepatitis C, kegg, {} ENSG00000105229~hsa05160 PIAS4, Hepatitis C, kegg, {} ENSG00000105568~hsa05160 PPP2R1A, Hepatitis C, kegg, {} ENSG00000107643~hsa05160 MAPK8, Hepatitis C, kegg, {} ENSG00000109339~hsa05160 MAPK10, Hepatitis C, kegg, {} ENSG00000113575~hsa05160 PPP2CA, Hepatitis C, kegg, {} ENSG00000124762~hsa05160 CDKN1A, Hepatitis C, kegg, {} ENSG00000131467~hsa05160 PSME3, Hepatitis C, kegg, {} ENSG00000156475~hsa05160 PPP2R2B, Hepatitis C, kegg, {} ENSG00000185386~hsa05160 MAPK11, Hepatitis C, kegg, {} ENSG00000213341~hsa05160 CHUK, Hepatitis C, kegg, {} ENSG00000221914~hsa05160 PPP2R2A, Hepatitis C, kegg, {} ENSG00000004975~hsa05200 DVL2, Pathways in cancer, kegg, {} ENSG00000005339~hsa05200 CREBBP, Pathways in cancer, kegg, {} ENSG00000033800~hsa05200 PIAS1, Pathways in cancer, kegg, {} ENSG00000050748~hsa05200 MAPK9, Pathways in cancer, kegg, {} ENSG00000051180~hsa05200 RAD51, Pathways in cancer, kegg, {} ENSG00000070831~hsa05200 CDC42, Pathways in cancer, kegg, {} ENSG00000073756~hsa05200 PTGS2, Pathways in cancer, kegg, {} ENSG00000078043~hsa05200 PIAS2, Pathways in cancer, kegg, {} ENSG00000080824~hsa05200 HSP90AA1, Pathways in cancer, kegg, {} ENSG00000082701~hsa05200 GSK3B, Pathways in cancer, kegg, {} ENSG00000095002~hsa05200 MSH2, Pathways in cancer, kegg, {} ENSG00000096384~hsa05200 HSP90AB1, Pathways in cancer, kegg, {} ENSG00000097007~hsa05200 ABL1, Pathways in cancer, kegg, {} ENSG00000100030~hsa05200 MAPK1, Pathways in cancer, kegg, {} ENSG00000100393~hsa05200 EP300, Pathways in cancer, kegg, {} ENSG00000100644~hsa05200 HIF1A, Pathways in cancer, kegg, {} ENSG00000100906~hsa05200 NFKBIA, Pathways in cancer, kegg, {} ENSG00000101109~hsa05200 STK4, Pathways in cancer, kegg, {} ENSG00000101412~hsa05200 E2F1, Pathways in cancer, kegg, {} ENSG00000102882~hsa05200 MAPK3, Pathways in cancer, kegg, {} ENSG00000104365~hsa05200 IKBKB, Pathways in cancer, kegg, {} ENSG00000105229~hsa05200 PIAS4, Pathways in cancer, kegg, {} ENSG00000107643~hsa05200 MAPK8, Pathways in cancer, kegg, {} ENSG00000109339~hsa05200 MAPK10, Pathways in cancer, kegg, {} ENSG00000112769~hsa05200 LAMA4, Pathways in cancer, kegg, {} ENSG00000116478~hsa05200 HDAC1, Pathways in cancer, kegg, {} ENSG00000123374~hsa05200 CDK2, Pathways in cancer, kegg, {} ENSG00000124762~hsa05200 CDKN1A, Pathways in cancer, kegg, {} ENSG00000134086~hsa05200 VHL, Pathways in cancer, kegg, {} ENSG00000135679~hsa05200 MDM2, Pathways in cancer, kegg, {} ENSG00000139618~hsa05200 BRCA2, Pathways in cancer, kegg, {} ENSG00000140464~hsa05200 PML, Pathways in cancer, kegg, {} ENSG00000147889~hsa05200 CDKN2A, Pathways in cancer, kegg, {} ENSG00000154229~hsa05200 PRKCA, Pathways in cancer, kegg, {} ENSG00000166949~hsa05200 SMAD3, Pathways in cancer, kegg, {} ENSG00000169083~hsa05200 AR, Pathways in cancer, kegg, {} ENSG00000169398~hsa05200 PTK2, Pathways in cancer, kegg, {} ENSG00000171552~hsa05200 BCL2L1, Pathways in cancer, kegg, {} ENSG00000171791~hsa05200 BCL2, Pathways in cancer, kegg, {} ENSG00000171862~hsa05200 PTEN, Pathways in cancer, kegg, {} ENSG00000175387~hsa05200 SMAD2, Pathways in cancer, kegg, {} ENSG00000186716~hsa05200 BCR, Pathways in cancer, kegg, {} ENSG00000196591~hsa05200 HDAC2, Pathways in cancer, kegg, {} ENSG00000196730~hsa05200 DAPK1, Pathways in cancer, kegg, {} ENSG00000198793~hsa05200 MTOR, Pathways in cancer, kegg, {} ENSG00000213341~hsa05200 CHUK, Pathways in cancer, kegg, {} ENSG00000050748~hsa05210 MAPK9, Colorectal cancer, kegg, {} ENSG00000082701~hsa05210 GSK3B, Colorectal cancer, kegg, {} ENSG00000095002~hsa05210 MSH2, Colorectal cancer, kegg, {} ENSG00000100030~hsa05210 MAPK1, Colorectal cancer, kegg, {} ENSG00000102882~hsa05210 MAPK3, Colorectal cancer, kegg, {} ENSG00000107643~hsa05210 MAPK8, Colorectal cancer, kegg, {} ENSG00000109339~hsa05210 MAPK10, Colorectal cancer, kegg, {} ENSG00000166949~hsa05210 SMAD3, Colorectal cancer, kegg, {} ENSG00000171791~hsa05210 BCL2, Colorectal cancer, kegg, {} ENSG00000175387~hsa05210 SMAD2, Colorectal cancer, kegg, {} ENSG00000050748~hsa05212 MAPK9, Pancreatic cancer, kegg, {} ENSG00000051180~hsa05212 RAD51, Pancreatic cancer, kegg, {} ENSG00000070831~hsa05212 CDC42, Pancreatic cancer, kegg, {} ENSG00000100030~hsa05212 MAPK1, Pancreatic cancer, kegg, {} ENSG00000101412~hsa05212 E2F1, Pancreatic cancer, kegg, {} ENSG00000102882~hsa05212 MAPK3, Pancreatic cancer, kegg, {} ENSG00000104365~hsa05212 IKBKB, Pancreatic cancer, kegg, {} ENSG00000107643~hsa05212 MAPK8, Pancreatic cancer, kegg, {} ENSG00000109339~hsa05212 MAPK10, Pancreatic cancer, kegg, {} ENSG00000139618~hsa05212 BRCA2, Pancreatic cancer, kegg, {} ENSG00000147889~hsa05212 CDKN2A, Pancreatic cancer, kegg, {} ENSG00000166949~hsa05212 SMAD3, Pancreatic cancer, kegg, {} ENSG00000171552~hsa05212 BCL2L1, Pancreatic cancer, kegg, {} ENSG00000175387~hsa05212 SMAD2, Pancreatic cancer, kegg, {} ENSG00000213341~hsa05212 CHUK, Pancreatic cancer, kegg, {} ENSG00000082701~hsa05213 GSK3B, Endometrial cancer, kegg, {} ENSG00000100030~hsa05213 MAPK1, Endometrial cancer, kegg, {} ENSG00000102882~hsa05213 MAPK3, Endometrial cancer, kegg, {} ENSG00000171862~hsa05213 PTEN, Endometrial cancer, kegg, {} ENSG00000100030~hsa05214 MAPK1, Glioma, kegg, {} ENSG00000101412~hsa05214 E2F1, Glioma, kegg, {} ENSG00000102882~hsa05214 MAPK3, Glioma, kegg, {} ENSG00000124762~hsa05214 CDKN1A, Glioma, kegg, {} ENSG00000135679~hsa05214 MDM2, Glioma, kegg, {} ENSG00000147889~hsa05214 CDKN2A, Glioma, kegg, {} ENSG00000154229~hsa05214 PRKCA, Glioma, kegg, {} ENSG00000171862~hsa05214 PTEN, Glioma, kegg, {} ENSG00000198793~hsa05214 MTOR, Glioma, kegg, {} ENSG00000005339~hsa05215 CREBBP, Prostate cancer, kegg, {} ENSG00000080824~hsa05215 HSP90AA1, Prostate cancer, kegg, {} ENSG00000082701~hsa05215 GSK3B, Prostate cancer, kegg, {} ENSG00000096384~hsa05215 HSP90AB1, Prostate cancer, kegg, {} ENSG00000100030~hsa05215 MAPK1, Prostate cancer, kegg, {} ENSG00000100393~hsa05215 EP300, Prostate cancer, kegg, {} ENSG00000100906~hsa05215 NFKBIA, Prostate cancer, kegg, {} ENSG00000101412~hsa05215 E2F1, Prostate cancer, kegg, {} ENSG00000102882~hsa05215 MAPK3, Prostate cancer, kegg, {} ENSG00000104365~hsa05215 IKBKB, Prostate cancer, kegg, {} ENSG00000118260~hsa05215 CREB1, Prostate cancer, kegg, {} ENSG00000123374~hsa05215 CDK2, Prostate cancer, kegg, {} ENSG00000124762~hsa05215 CDKN1A, Prostate cancer, kegg, {} ENSG00000135679~hsa05215 MDM2, Prostate cancer, kegg, {} ENSG00000169083~hsa05215 AR, Prostate cancer, kegg, {} ENSG00000171791~hsa05215 BCL2, Prostate cancer, kegg, {} ENSG00000171862~hsa05215 PTEN, Prostate cancer, kegg, {} ENSG00000198793~hsa05215 MTOR, Prostate cancer, kegg, {} ENSG00000213341~hsa05215 CHUK, Prostate cancer, kegg, {} ENSG00000100030~hsa05216 MAPK1, Thyroid cancer, kegg, {} ENSG00000102882~hsa05216 MAPK3, Thyroid cancer, kegg, {} ENSG00000004975~hsa05217 DVL2, Basal cell carcinoma, kegg, {} ENSG00000082701~hsa05217 GSK3B, Basal cell carcinoma, kegg, {} ENSG00000100030~hsa05218 MAPK1, Melanoma, kegg, {} ENSG00000101412~hsa05218 E2F1, Melanoma, kegg, {} ENSG00000102882~hsa05218 MAPK3, Melanoma, kegg, {} ENSG00000124762~hsa05218 CDKN1A, Melanoma, kegg, {} ENSG00000135679~hsa05218 MDM2, Melanoma, kegg, {} ENSG00000147889~hsa05218 CDKN2A, Melanoma, kegg, {} ENSG00000171862~hsa05218 PTEN, Melanoma, kegg, {} ENSG00000100030~hsa05219 MAPK1, Bladder cancer, kegg, {} ENSG00000101412~hsa05219 E2F1, Bladder cancer, kegg, {} ENSG00000102882~hsa05219 MAPK3, Bladder cancer, kegg, {} ENSG00000124762~hsa05219 CDKN1A, Bladder cancer, kegg, {} ENSG00000135679~hsa05219 MDM2, Bladder cancer, kegg, {} ENSG00000147889~hsa05219 CDKN2A, Bladder cancer, kegg, {} ENSG00000196730~hsa05219 DAPK1, Bladder cancer, kegg, {} ENSG00000097007~hsa05220 ABL1, Chronic myeloid leukemia, kegg, {} ENSG00000100030~hsa05220 MAPK1, Chronic myeloid leukemia, kegg, {} ENSG00000100906~hsa05220 NFKBIA, Chronic myeloid leukemia, kegg, {} ENSG00000101412~hsa05220 E2F1, Chronic myeloid leukemia, kegg, {} ENSG00000102882~hsa05220 MAPK3, Chronic myeloid leukemia, kegg, {} ENSG00000104365~hsa05220 IKBKB, Chronic myeloid leukemia, kegg, {} ENSG00000116478~hsa05220 HDAC1, Chronic myeloid leukemia, kegg, {} ENSG00000124762~hsa05220 CDKN1A, Chronic myeloid leukemia, kegg, {} ENSG00000135679~hsa05220 MDM2, Chronic myeloid leukemia, kegg, {} ENSG00000147889~hsa05220 CDKN2A, Chronic myeloid leukemia, kegg, {} ENSG00000166949~hsa05220 SMAD3, Chronic myeloid leukemia, kegg, {} ENSG00000171552~hsa05220 BCL2L1, Chronic myeloid leukemia, kegg, {} ENSG00000186716~hsa05220 BCR, Chronic myeloid leukemia, kegg, {} ENSG00000196591~hsa05220 HDAC2, Chronic myeloid leukemia, kegg, {} ENSG00000213341~hsa05220 CHUK, Chronic myeloid leukemia, kegg, {} ENSG00000033800~hsa05222 PIAS1, Small cell lung cancer, kegg, {} ENSG00000073756~hsa05222 PTGS2, Small cell lung cancer, kegg, {} ENSG00000078043~hsa05222 PIAS2, Small cell lung cancer, kegg, {} ENSG00000100906~hsa05222 NFKBIA, Small cell lung cancer, kegg, {} ENSG00000101412~hsa05222 E2F1, Small cell lung cancer, kegg, {} ENSG00000104365~hsa05222 IKBKB, Small cell lung cancer, kegg, {} ENSG00000105229~hsa05222 PIAS4, Small cell lung cancer, kegg, {} ENSG00000112769~hsa05222 LAMA4, Small cell lung cancer, kegg, {} ENSG00000123374~hsa05222 CDK2, Small cell lung cancer, kegg, {} ENSG00000169398~hsa05222 PTK2, Small cell lung cancer, kegg, {} ENSG00000171552~hsa05222 BCL2L1, Small cell lung cancer, kegg, {} ENSG00000171791~hsa05222 BCL2, Small cell lung cancer, kegg, {} ENSG00000171862~hsa05222 PTEN, Small cell lung cancer, kegg, {} ENSG00000213341~hsa05222 CHUK, Small cell lung cancer, kegg, {} ENSG00000100030~hsa05223 MAPK1, Non-small cell lung cancer, kegg, {} ENSG00000101109~hsa05223 STK4, Non-small cell lung cancer, kegg, {} ENSG00000101412~hsa05223 E2F1, Non-small cell lung cancer, kegg, {} ENSG00000102882~hsa05223 MAPK3, Non-small cell lung cancer, kegg, {} ENSG00000147889~hsa05223 CDKN2A, Non-small cell lung cancer, kegg, {} ENSG00000154229~hsa05223 PRKCA, Non-small cell lung cancer, kegg, {}